WorksheetsFibrinolysis
Total questions: 15
Worksheet time: 8mins
A primary inhibitor of the fibrinolytic system is:
alpha-2 antiplasmin
alpha-2 macroglobulin
antithrombin
Protein C
D-dimers are elevated in which of the following conditions?
Primary fibrinolysis
Deep vein thrombosis
hemophilia A
Glanzmann's thrombasthenia
All of the following are functions of thrombin except:
Activating factors V, VIII, and XIII
Activating platelets
Activating thromboplastin
Converting fibrinogen to fibrin
Which of the following is the best possible treatment for a patient with DIC?
Provide supporting blood products
Give the patient tPA if there is excessive clotting
Resolve the underlying cause of DIC
Give the patient heparin therapy
What is the primary purpose of the fibrinolytic system?
To form a stable fibrin clot
to activate the complement system
to restore blood flow at the local level
to inhibit coagulation
Which of the following is true in the condition known as DIC?
FV and FVIII become increased in activity
fibrinolytic activity is absent
the patient has a single coagulation factor deficiency
Fibrinogen and platelets become depleted
D-dimer formation is the result of the action of plasmin on:
fibrin monomer
fibrinogen
cross-linked fibrin
FDPs
In primary fibrinolysis, which of the following lab tests will be abnormal?
Platelet count
d-dimer
fibrinopeptide A level
Thrombin Time
The primary tissue source for tissue plasminogen activator (tPA) is:
Streptococcal bacteria
Kidney
Endothelial cells
Pluripotential stem cells
Unregulated and excessive formation of thrombin and plasmin is seen in:
Liver disease
vitamin K deficiency
primary fibrinolysis
DIC
Which of the following tests is diagnostic in DIC?
thrombin time
d-dimer
fibrinogen
none of the above
Which of the following plasmin activators is synthesized by the kidney?
tPA
uPA
FXIIa
Kallikrein
What causes inactivation of factors Va and VIIIa?
Thrombin
Protein S
tPA
Activated Protein C (APC)
What is the primary inhibitor of plasminogen activators?
PAI-1
PAI-2
TAFI
alpha-2-antiplasmin
Which of the following deficiencies results in a bleeding disorder?
Plasminogen
tPA
PAI-1
uPA
