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WorksheetsENIGMA Pre-Test
Total questions: 10
Worksheet time: 5mins
The most common immunophenotypic finding in MPAL
B/ myeloid
T/ myeloid
B/T lymphoblastic
Trilineage co-expression
True of mixed phenotype acute leukemia EXCEPT:
CNS involvement are relatively infrequent
There is no difference in survival between patients who underwent HSCT in first or second CR
Blinatumomab and Donor lymphocyte infusion may be considered in relapsed MPAL patients
Has bimodal age distribution
Most sensitive test to detect myeloperoxidase
Enzyme cytochemistry
Flow cytometry
IHC
RT-PCR
TRUE of Mixed phenotypic leukemia except:
Median age at diagnosis is 20-30 years old
Slight female predominance
Incidence higher in adults than children
Bimodal age distribution
True in the treatment of mixed phenotypic leukemia until first remission
Use ALL based regimen
Use AML based regimen
Use ALL based regimen followed by HSCT
Use AML based regimen followed by HSCT
Mutation in this signaling were previously described in the context of lineage switch from AML to T-ALL
NOTCH1
NOTCH2
NOTCH3
NOTCH4
Diagnosis of Mixed phenotypic acute leukemia according to the European Group for Immunological characterization of Leukemias
Score >1 for myeloid and/ lymphoid lineages
Score >2
Score >4
Score > 6
Treatment guidelines for MPAL is not clearly established
TRUE
FALSE
Patients with Philadelphia positive (Ph+) MPAL who received TKIs had a significant reduction in the risk of death in comparison to Ph (-) MPAL patients
TRUE
FALSE
Cases of CNS involvement are relatively frequent in MPAL
TRUE
FALSE
