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IMSLECP1

Total questions: 50

Worksheet time: 25mins

Name
Class
Date
1.

Molecular weight over 10,000 Daltons; almost always protein in nature

a)

Carrier

b)

Antigen

2.

portion recognized as foreign, reacts specifically with an antibody receptor

a)

Carrier

b)

Antigenic determinant or haptene

c)

Complete antigen

d)

Incomplete antigen

3.

with 2 parts carrier and haptene

a)

Carrier

b)

Antigenic determinant or haptene

c)

Complete antigen

d)

Incomplete antigen

4.

either carrier or haptene

a)

Carrier

b)

Antigenic determinant or haptene

c)

Complete antigen

d)

Incomplete antigen

5.

antigens that belong to the host

a)

autoantigens

b)

alloantigens

c)

heteroantigens

d)

heterophile antigens

6.

from the same species and capable of eliciting an immune response

a)

autoantigens

b)

alloantigens

c)

heteroantigens

d)

heterophile antigens

7.

are from other species, such as other animals, plants or microorganisms.

a)

autoantigens

b)

alloantigens

c)

heteroantigens

d)

heterophile antigens

8.

are heterogens that exist in unrelated plants or animals but are either identical or closely related in structure so that antibody to one will cross=react with antigen of the other

a)

autoantigens

b)

alloantigens

c)

heteroantigens

d)

heterophile antigens

9.

* Present on the body

* Recognition by T cells

* Highest on lymphocytes and low or undetected on liver hepatocytes, neural cells, muscle cells, and sperm

a)

Class I MHC

b)

Class II MHC

c)

Class III MHC

d)

Class IV MHC

10.

* found primarily on, which include B lymphocytes, monocytes, macrophages, and dendritic cells

* recognize by B cells

a)

Class I MHC

b)

Class II MHC

c)

Class III MHC

d)

Class IV MHC

11.

* minor MHC antigens

* activate complement factor 3 by either classical *(C2,C4a,C4b) or alternative pathway

a)

Class I MHC

b)

Class II MHC

c)

Class III MHC

d)

Class IV MHC

12.

Related disease:

Ankylosing Spondylitis

a)

B27

b)

B8

c)

DR2

d)

DR2/DR3

e)

DR3/DR4

13.

Related disease:

Myasthenia gravis, Celiac disease

a)

B27

b)

B8

c)

DR2

d)

DR2/DR3

e)

DR3/DR4

14.

Related disease:

Multiple sclerosis

a)

B27

b)

B8

c)

DR2

d)

DR2/DR3

e)

DR3/DR4

15.

Related disease:

SLE

a)

DR4/DR5

b)

B8

c)

DR2

d)

DR2/DR3

e)

DR3/DR4

16.

Related disease:

IDDM/ Type I diabetes

a)

DR4/DR5

b)

B8

c)

DR4

d)

DR2/DR3

e)

DR3/DR4

17.

Related disease:

RA or Rentigus Vulgaris

a)

DR4/DR5

b)

B8

c)

DR4

d)

DR2/DR3

e)

DR3/DR4

18.

Related disease:

Hashimoto's disease

a)

DR4/DR5

b)

B8

c)

DR4

d)

DR2/DR3

e)

DR3/DR4

19.

HLA TESTING:

Dye : trypan blue or eosin

Classic method using purified T lymphocytes (Class I typing) and B lymphoctres

a)

Microlymphocytotoxicity test

b)

Mixed lymphocytes culture

c)

DNA based typing method

d)

Ficoll - Hipaque

e)

Nylon wool technique

20.

HLA TESTING:

measurement of the degree of radioactivity by liquid scintillation counting

a)

Microlymphocytotoxicity test

b)

Mixed lymphocytes culture

c)

DNA based typing method

d)

Ficoll - Hipaque

e)

Nylon wool technique

21.

HLA TESTING:

nucleic acid amplification (PCR) and sequencing

a)

Microlymphocytotoxicity test

b)

Mixed lymphocytes culture

c)

DNA based typing method

d)

Ficoll - Hipaque

e)

Nylon wool technique

22.

HLA TESTING:

separate lymphocytes from whole blood

a)

Microlymphocytotoxicity test

b)

Mixed lymphocytes culture

c)

DNA based typing method

d)

Ficoll - Hipaque

e)

Nylon wool technique

23.

HLA TESTING:

separate B and T cells

a)

Microlymphocytotoxicity test

b)

Mixed lymphocytes culture

c)

DNA based typing method

d)

Ficoll - Hipaque

e)

Nylon wool technique

24.

A flexible Y-shaped molecule with four protein chains

a)

Monomer

b)

Variable Region

c)

Constant Region

d)

Contains Region

e)

Hinge region

25.

*2 sections at the end of Y's arm

* contain the antigen binding sites

* identical n the same antibody but vary from one antibody to another

a)

Monomer

b)

Variable Region

c)

Constant Region

d)

Contains Region

e)

Hinge region

26.

* stem of monomer and lower parts of Y arms

a)

Monomer

b)

Variable Region

c)

Constant Region

d)

Contains Region

e)

Hinge region

27.

* area that gives molecule flexibility allowing for multiple binding sites

* located between the CH1 and CH2 domains

a)

Monomer

b)

Variable Region

c)

Constant Region

d)

Contains Region

e)

Hinge region

28.

Which of the following is NOT properties of an antibody

a)

Protein in nature

b)

High MW more than 150,000

c)

substances recognized as foreign by body

d)

present in serum/plasma, CSF, saliva and seminal fluid

29.

consists of 214 amino acid residue

a)

kappa chain

b)

lambda chain

30.

responsible for immobilization of motile organisms and for cell clumoing

a)

agglutinins

b)

hemaagglutinins

c)

precipitins

d)

lysins

e)

opsonins

31.

agglutination of rbc

a)

agglutinins

b)

hemaagglutinins

c)

precipitins

d)

lysins

e)

opsonins

32.

demonstrated only against soluble antigens

a)

agglutinins

b)

hemaagglutinins

c)

precipitins

d)

lysins

e)

opsonins

33.

cause dissolution of antigenic cells

a)

agglutinins

b)

hemaagglutinins

c)

precipitins

d)

lysins

e)

opsonins

34.

act upon bacterial invaders

a)

agglutinins

b)

hemaagglutinins

c)

precipitins

d)

lysins

e)

opsonins

35.

render antigenic microorganism (usually viruses) harmless [streptolysin O]

a)

neutralizing antibodies

b)

allergic antibodies

c)

antitoxins

d)

complement fixing antibodies

e)

blocking or inhibitory antibodies

36.

react with allergens

a)

neutralizing antibodies

b)

allergic antibodies

c)

antitoxins

d)

complement fixing antibodies

e)

blocking or inhibitory antibodies

37.

which neutralize specific toxins

a)

neutralizing antibodies

b)

allergic antibodies

c)

antitoxins

d)

complement fixing antibodies

e)

blocking or inhibitory antibodies

38.

combine with antigen but are not grossly detectable

a)

neutralizing antibodies

b)

allergic antibodies

c)

antitoxins

d)

complement fixing antibodies

e)

blocking or inhibitory antibodies

39.

> Monomer

> Highest concentration in placenta

> transported across the placenta

> react best at body temp

a)

IgG

b)

IgA

c)

IgM

d)

IgE

e)

IgD

40.

> Monomer/Dimer

> Major protective factor in colostrum

> in milk, tear, saliva, interstinal mucus

a)

IgG

b)

IgA

c)

IgM

d)

IgE

e)

IgD

41.

> Pentamer (held by J chains)

> 1st antibody that infanHighest agglutinating capacityt makes

>

a)

IgG

b)

IgA

c)

IgM

d)

IgE

e)

IgD

42.

> monomer

> mediated type 1 hypersensitivity

> Main host defense against helminth infection

a)

IgG

b)

IgA

c)

IgM

d)

IgE

e)

IgD

43.

> monomer

> uncertain

> present in the membrane of mature B cells

a)

IgG

b)

IgA

c)

IgM

d)

IgE

e)

IgD

44.

* Antigenic (amino acid) differences in their constant heavy region

* Heavy chain isotypes: 9

* Total isotypes: 18

a)

Isotypes

b)

Allotypes

c)

Idiotypes

45.

* additional antigenic features of Ig that vary among individuals

* no biological significance

* results from substitution of only one or two amino acids in the constant regions of heavy or light chains

a)

Isotypes

b)

Allotypes

c)

Idiotypes

46.

* individually specific to each Ig molecule

* antigenic determinants formed by the specific amino acids ub hypervariable region

a)

Isotypes

b)

Allotypes

c)

Idiotypes

47.

antigens that belong to the host

a)

Autoantigens

b)

Alloantigens

c)

Heteroantigens

d)

Hetrophile Antigens

48.

are from the same species capable of eliciting an immune system

a)

Autoantigens

b)

Alloantigens

c)

Heteroantigens

d)

Hetrophile Antigens

49.

are from other species, such as other animals, plants, or microorganisms

a)

Autoantigens

b)

Alloantigens

c)

Heteroantigens

d)

Hetrophile Antigens

50.

Molecular weight over 10,000 dalton; almost always protein in nature

a)

Carrier

b)

Antigenic determinant or haptene

c)

Complete antigen

d)

Incomplete antigen

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