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WorksheetsDNA Replication
Total questions: 35
Worksheet time: 32mins
The separation of the two single strands of DNA creates a ‘Y’ shape?
enzyme
unzip
A replication fork
direction new nucleotides are synthesized on the new strand
5' to 3' (new nucleotides added to the 3' end)
3' to 5' (new nucleotides added to the 5' end)
3' to 5' (new nucleotides added to the 3' end)
5' to 3' (new nucleotides added to the 5' end)
Which of the following statements about DNA replication is TRUE?
the leading strand is replicated continuously, while the lagging strand is replicated discontinuously
the leading strand is replicated discontinuously, while the lagging strand is replicated continuously
both the leading and lagging strands are replicated continuously
both the leading and lagging strands are replicated discontinuously
each of the leading and lagging strands is replicated both continuously and discontinuously
The Meselson-Stahl experiment demonstrated that DNA replication produces two DNA molecules each composed of
Two old strands
Two new strands
One old strand and one new strand
two strands with variable proportions of new and old DNA.
This is the correct model for DNA Replication.
True
False
This is the correct model for DNA Replication.
True
False
Okazaki fragments are used to elongate
)the leading strand toward the replication fork
the lagging strand toward the replication fork
both strands in both directions
)the leading strand away from the replication fork
the lagging strand away from the replication fork
Which of the following statements about DNA replication is not true?
The process insures that each new cell will have the same genetic material as the original cell
The process begins at a single location on the DNA molecule called the origin of replication
The process is defined as semiconservative replication
Results in chromosomes that contain 2 DNA molecules called sister chromatids
During semiconservative replication, the original double helix remains intact and a new double helix forms.
True
False
What enzyme breaks hydrogen bonds during DNA replication?
(a)
What enzyme adds in new nucleotides and proofreads the new strands?
(a)
What enzyme reforms hydrogen bonds between bases?
(a)
Where does DNA occur in eukaryotes?
(a)
Where does DNA replication occur in prokaryotes?
(a)
How many sites of origin do prokaryotes have when replicating their DNA?
(a)
Like prokaryotes, eukaryotes have one origin of replication
True
False
_______ is the enzyme that closes the gaps between ___________ on the lagging strand.
DNA Polymerase I ; Okasaki fragments
Ligase ; RNA primers
Primase ; RNA Primers
Ligase ; Okasaki fragments
DNA polymerase _______ synthesizes the daughter strand, and DNA polymerase _______ replaces RNA primer with DNA nucleotides
I ; III
I ; II
III ; II
III ; I
Why are single-stranded binding proteins (SSBP) necessary for DNA replication? Select al that apply!
They turn double-stranded DNA into single-stranded DNA
The work done by helicase would be undone
Hydrogen bonds would reform if SSBPs were absent
They ensure the replication bubble stays open
Phosphodiester bonds would reform if the SSBPs were absent
What would happen if primase was dysfunctional?
The hydrogen bonds of the double helix would reform
RNA primer would not be laid down
The Okasaki fragments would not be fused
Twisting tension would damage the DNA
Which of the following are TRUE of the lagging strand? Select all that apply!
The newest Okasaki fragment is closest to the replication fork
The newest Okasaki fragment is furthest to the replication fork
It is synthesized in the 5' --> 3' direction
Okasaki fragments are made of ribonucleotides (RNA)
It is synthesized after the leading strand is complete
Which of the following is TRUE of the leading strand?
It contains Okasaki fragments
It needs ligase
It is synthesized towards the replication fork
It is synthesized in the 3' to 5' direction
