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WorksheetsPharmacology: anticonvulsant
Total questions: 16
Worksheet time: 6mins
Which of the following anti-seizure medications is not eliminated by the liver
Pregabalin
Phenobarbital
Phenytoin
Carbamazepine
Pregabalin works on presynaptic ion channels to inhibit the release of neurotransmitter and reduce neuronal excitation. What ion channel does pregabalin act on?
Potassium
Chloride
Sodium
Calcium
Which is the most common treatment for epilepsy?
Surgery
Special Diet
Medication
An implanted electrical device
The symptoms of a seizure may differ from person to person, but seizures are caused by the same thing:
A sudden change in how brain cells send electrical signals to one another
A sudden change in how the spinal cord and brain talk to each other
A sudden change in blood flow in the brain
A sudden change in oxygen flow in the body
Characteristic of acute symptomatic seizure is ...
Unprovoked seizure
Provoked seizure
Recurrent
related with intracranial abnormality
A female, 38 yo, had multiple seizures and her blood glucose level was very high (600mg/dL). What was an episode that she had?
Focal onset Epilepsy
Acute symptomatic seizure
General onset epilepsy
Undetermined yet
What biomarker is used for epilepsy diagnosis?
HVA Calcium
Prolactin
MOA
COMT
Among the different types of seizures, this type is characterized by impaired consciousness and recall. If asked a question, the patient might respond with an inappropriate or unintelligible answer. Automatic movements involve the mouth and face (lip smacking, chewing, tasting, and swallowing movements), upper extremities (fumbling, picking, tapping, or clasping movements), and vocal apparatus (grunts or repetition of words and phrases), as are complex acts (such as walking or mixing foods in a bowl).
Focal ( aware)
Focal ( impaired awareness)
Tonic-clonic
Absence
Barbiturates and benzodiazepines are anticonvulsant drugs used in the treatment of epilepsy. They both bind to distinct site if the same receptor complex and differentially influence the opening and closing of chloride ion pore. What main characteristic differs the mechanism of action?
Barbiturates increase the duration of chloride channel opening.Benzodiazepines increase the frequency of opening.
Barbiturates increase the GABAa receptors and benzodiazepines increases GABAb receptors.
Barbiturates prevent the removal of GABA from the synaptic cleft by blockade of GABA transport and Benzodiazepines are irreversible inhibitors of the mitochondrial enzyme GABA.
Barbiturates increase the frequency of opening.Benzodiazepines increase the duration of chloride channel opening.
Which drug is most useful for the treatment of absence seizures?
Topiramate - only used for focal seizures
Tiagabine
Levetiracetam
Lamotrigine
Which type of generalized seizures consist of short episodes of muscle contractions that may occur for several minutes?
Myoclonic
Tonic- Clonic
Absence
Atonic
T or F? Carbamazepine should not be prescribed for patients with absence seizures because it may cause an increase in seizures
T
F
Focal seizures involve how many hemispheres of the brain?
1
2
3
4
T or F? Generalized seizures begin locally and then progress to include abnormal electrical discharges throughout both hemispheres of the brain?
T
F
Atonic seizures are known as
Increased tone in the extension muscles
Drop attacks characterized by sudden loss of muscle tone
Short episodes of muscle contractions
Loss of consciousness
T or F? Clonic seizures begin with a loss of consciousness and a sudden loss of muscle tone which is followed by limb jerking
T
F
