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Musculoskeletal Disorder

Total questions: 17

Worksheet time: 17mins

Name
Class
Date
1.

HLA DR4, HLA DR1 antigens are found in MHC of_____patients

a)

osteoporosis

b)

rheumatoid arthritis

c)

osteoarthritis

d)

gout

2.

The followings are the examples of autoimmune diseases except

a)

type I diabetes

b)

graves disease

c)

rheumatoid arthritis

d)

type II diabetes

3.

Inflamed synovial granulation tissue is called

a)

Pannus

b)

Synovium

c)

Neutropenia

d)

Granulosum

4.

Osteophyte formation is characteristic of Rheumatoid arthritis.

a)

True

b)

False

5.

...... is a craking or popping sound may be heard or felt when moving the joint.

a)

Crepitus

b)

Crocotus

c)

Cramitus

d)

Colotus

6.

Which of the following phases is responsible for producing an immediate response to injury?

a)

Maturation

b)

Proliferative

c)

Inflammatory

d)

Glycolysis

7.

......maintain the extracellular matrix (ECM) and produce the cartilage matrix.

a)

Chondrocytes

b)

Astrocyte

c)

Dandrocyte

d)

Octocyte

8.

Hyaluronic acid works by acting like a lubricant and shock absorber in the joints and helps the joints to work properly. It is used in.....

a)

Osteoarthritis

b)

Rheumatoid arthritis

c)

Bone Fracture

d)

Inflammatory conditions

9.

The .............. is associated with both the development and severity of Rheumatoid Arthritis.

a)

HLA-DR4

b)

CD4

c)

CD8

d)

Chromatin

10.

.......... is characterized by numbness and tingling in the thumb, index finger, middle finger and the thumb side of the ring finger

a)

Steven Johnson Syndrome

b)

Carpal tunnel syndrome

c)

Peripheral Inflammatory syndrome

d)

Bone fracture

11.

........is/are diagnostic markers of Rheumatoid Arthritis

a)

RF

b)

Anti-Citrullinated Peptide (CCP) antibody

c)

Both RF and Anti-CCP antibody

d)

Only RF

12.

...is/ are Janus kinase (JAK) inhibitor(s)

a)

Tofacitinib

b)

Baricitinib

c)

Tofacitinib and Baricitinib

d)

Imatinib

13.

......is currently considered a drug of first choice in the treatment of rheumatoid arthritis. It is a non-biologic Disease Modifying Anti-Rheumatic Drug (DMARD).

a)

Aspirin

b)

Methotrexate

c)

Everolimus

d)

Prednisone

14.

...... causes the accumulation of adenosine. Adenosine has potent antiinflammatory effects, including a reduction in the number of activated T cells and reduced levels of TNF-alpha.

a)

Methotrexate

b)

Diclofenac

c)

Celecoxib

d)

Ibuprofen

15.

While TNF-alpha inhibitors are the most commonly used biologic DMARDs, an IL-6 receptor antagonist has also been found to be effective in treating arthritis. An example of this drug class is...

a)

 leflunomide

b)

tocilizumab

c)

abatacept

d)

sulfasalazine

16.

JQ is a professional 40 year old golfer who has developed a progressively more painful stiffness in her arms and legs over the past year that interferes with her ability to compete in golf tournaments. During her most recent medical checkup, her lab results reveal an elevated erythrocyte sedimentation rate (ESR), elevated CRP level and a high RF level. Xray imaging revealed the presence of bilateral erosion of several joints in her arms and legs. After being referred to a rheumatologist, she is prescribed methotrexate. But condition was not improved hence Adalimumab was prescribed which is...

a)

Protein kinase inhibitor

b)

TNF alpha inhibitor

c)

Janus Kinase inhibitor

d)

Phospohokinase inhibitor

17.

Sulfasalazine, sold under the brand name Azulfidine among others, is a medication used to treat

a)

rheumatoid arthritis

b)

ulcerative colitis

c)

Crohn's disease.

d)

All are correct