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PCOL ANALGESICS PART 2

Total questions: 127

Worksheet time: 1hrs 4mins

Name
Class
Date
1.

has a very long half-life

a)

Oxaprozin

b)

Mefenamic acid

c)

Phenylbutazone

d)

Indomethacin

2.

more useful in gout than some other NSAIDs.

a)

Oxaprozin

b)

Mefenamic acid

c)

Phenylbutazone

d)

Indomethacin

3.

Oxaprozin

a)

Daypro

b)

Ansaid

c)

Orudis

4.

Flurbiprofen

a)

Daypro

b)

Ansaid

c)

Orudis

5.

Ketoprofen

a)

Daypro

b)

Ansaid

c)

Orudis

6.

has a very long half-life

a)

Daypro

b)

Ansaid

c)

Orudis

7.

more useful in gout than some other NSAIDs.

a)

Daypro

b)

Ansaid

c)

Orudis

8.

used to accelerate closure of patent ductus arteriosus

a)

Indomethacin

b)

Ibuprofen

c)

Nabumetone

d)

Piroxicam

9.

used to accelerate closure of patent ductus arteriosus

a)

Indocin

b)

Anturane

c)

Novalgin

d)

Relafen

10.

prolongs indomethacin’s half-life by inhibiting both renal and biliary clearance

a)

Probenecid

b)

Naloxone

c)

Nabumetone

11.

– NSAID that has the highest chance to cause kidney as well as damage in the stomach. Most toxic NSAID

a)

Indocin

b)

Anturane

c)

Novalgin

d)

Relafen

12.

– NSAID that has the highest chance to cause kidney as well as damage in the stomach. Most toxic NSAID

a)

Indomethacin

b)

Ibuprofen

c)

Nabumetone

d)

Piroxicam

13.

Peptic ulcer risk is as much as 9.5 times

a)

Indomethacin

b)

Ibuprofen

c)

Nabumetone

d)

Piroxicam

14.

Piroxicam

a)

Feldene

b)

Mobic

c)

Probenecid

15.

Meloxicam

a)

Feldene

b)

Mobic

c)

Probenecid

16.

NSAID that causes higher tendency of PUD (higher with piroxicam than with other NSAIDs)

a)

Piroxicam and Meloxicam

b)

Nabumetone

c)

Indomethacin

d)

Oxaprozin

17.

Mefenamic acid 250mg (OTC) Mefenamic acid 500mg (Rx)

a)

true

b)

false

18.

Should not be used more than 5 days (acute mgt.of pain)

a)

Mefenamic acid

b)

Flufenamic acid

c)

Meclofenamic acid

d)

Piroxicamic acid

19.

Contraindicated: <14 Y/0

a)

Mefenamic acid

b)

Flufenamic acid

c)

Meclofenamic acid

d)

Piroxicamic acid

20.

Powerful analgesics & Good anti-inflammatory effects

a)

Phenylbutazone (Zolandin), Dipyrone (Novalgin), Sufinpyrazone (Anturane)

b)

Mefenamic acid (Dolfenal, Ponstan) Flufenamic acid, Meclofenamic acid

c)

Piroxicam (Feldene) and Meloxicam (Mobic)

21.

Phenylbutazone

a)

Zolandin

b)

Novalgin

c)

Anturane

22.

Dipyrone

a)

Zolandin

b)

Novalgin

c)

Anturane

23.

Sufinpyrazone

a)

Zolandin

b)

Novalgin

c)

Anturane

24.

A/E: Anasarca (generalized edema)

a)

Phenylbutazone (Zolandin), Dipyrone (Novalgin), Sufinpyrazone (Anturane)

b)

Mefenamic acid (Dolfenal, Ponstan) Flufenamic acid, Meclofenamic acid

c)

Piroxicam (Feldene) and Meloxicam (Mobic)

25.

only nonacid NSAID in current use

a)

Nabumetone

b)

Piroxicam

c)

Indomethacin

d)

Oxaprozin

26.

only nonacid NSAID in current use

a)

Relafen

b)

Feldene

c)

Indocin

d)

Daypro

27.

converted to the active acetic acid derivative in the body

a)

Relafen

b)

Feldene

c)

Indocin

d)

Daypro

28.

converted to the active acetic acid derivative in the body

a)

Nabumetone

b)

Piroxicam

c)

Indomethacin

d)

Oxaprozin

29.

given as a ketone prodrug that resembles naproxen

a)

Nabumetone

b)

Piroxicam

c)

Indomethacin

d)

Oxaprozin

30.

given as a ketone prodrug that resembles naproxen

a)

Relafen

b)

Feldene

c)

Indocin

d)

Daypro

31.

NSAID that is less damaging to the gastrointestinal tract

a)

Relafen

b)

Feldene

c)

Indocin

d)

Daypro

32.

NSAID that is less damaging to the gastrointestinal tract

a)

Nabumetone

b)

Piroxicam

c)

Indomethacin

d)

Oxaprozin

33.

Associated with pseudoporphyria and photosensitivity

a)

Nabumetone

b)

Piroxicam

c)

Indomethacin

d)

Oxaprozin

34.

Associated with pseudoporphyria and photosensitivity

a)

Relafen

b)

Feldene

c)

Indocin

d)

Daypro

35.

All NSAIDs, including aspirin, are about equally efficacious. Thus, NSAIDs tend to be differentiated on the basis of toxicity and cost-effectiveness.

a)

1st correct

b)

2nd correct

c)

both wrong

d)

both correct

36.

Analgesic, antipyretic, and anti-inflammatory effects similar to those of NSAIDs

a)

COX-2 Selective inhibitors

b)

COX-1 Selective inhibitors

c)

COX-2 Non Selective inhibitors

d)

COX-1 Non Selective inhibitors

37.

Adv: probably safest for patients at high risk for GI bleeding

a)

COX-2 Selective inhibitors

b)

COX-1 Selective inhibitors

c)

COX-2 Non Selective inhibitors

d)

COX-1 Non Selective inhibitors

38.

relatively expensive

a)

COX-2 Selective inhibitors

b)

COX-1 Selective inhibitors

c)

COX-2 Non Selective inhibitors

d)

COX-1 Non Selective inhibitors

39.

Disadv: higher risk of cardiovascular toxicity (cardiovascular thrombotic event)

a)

COX-2 Selective inhibitors

b)

COX-1 Selective inhibitors

c)

COX-2 Non Selective inhibitors

d)

COX-1 Non Selective inhibitors

40.

inhibit prostaglandin synthesis by the COX-2 isozyme induced at sites of inflammation without affecting the action of the constitutively active “housekeeping” COX-1 isozyme found in the GI tract, kidneys, and platelets.

a)

COX-2 Selective inhibitors

b)

COX-1 Selective inhibitors

c)

COX-2 Non Selective inhibitors

d)

COX-1 Non Selective inhibitors

41.

Celecoxib

a)

Celebrex, Celcox

b)

Mobic

c)

arcoxia

d)

Vioxx

e)

Bextra

42.

Meloxicam

a)

Celebrex, Celcox

b)

Mobic

c)

arcoxia

d)

Vioxx

e)

Bextra

43.

Etoricoxib

a)

Celebrex, Celcox

b)

Mobic

c)

arcoxia

d)

Vioxx

e)

Bextra

44.

Rofecoxib

a)

Celebrex, Celcox

b)

Mobic

c)

arcoxia

d)

Vioxx

e)

Bextra

45.

Rofecoxib

a)

Celebrex, Celcox

b)

Mobic

c)

arcoxia

d)

Vioxx

e)

Bextra

46.

Valdecoxib (Bextra) and Rofecoxib (Mobic) are COX 2 selective that are not widely available today, in fact they have been withdrawn specially in the market in the US

a)

true

b)

false

47.

also known as opium tincture

a)

Laudanum

b)

Paregoric

48.

camphorated opium tincture

a)

Laudanum

b)

Paregoric

49.

employed opium to battle headaches, coughing, asthma and melancholy

a)

Hippocrates

b)

Galen

c)

Friedrich Wilhelm Adam Sertürner

50.

German Pharmacist that  isolated Morphine in 1805

a)

Hippocrates

b)

Galen

c)

Friedrich Wilhelm Adam Sertürner

51.

Greek god of dream & sleep

a)

Morpheus

b)

Morphies

c)

Morphus

52.

Opioid-like substances produced in the brain

a)

ENDOGENOUS OPIOIDS

b)

OPIOID ANALGESICS

c)

NARCOTIC ANLAGESICS

d)

MILD ANALGESICS

53.

a.k.a. “Endorphins”

a)

ENDOGENOUS OPIOIDS

b)

OPIOID ANALGESICS

c)

NARCOTIC ANLAGESICS

d)

MILD ANALGESICS

54.

Generic term contracted from endogenous and morphine, all used for brain peptides with opiate like activity. Once it activate the receptors, it reduces pain and inc. sensation of well being (feel good hormone)

a)

ENDOGENOUS OPIOIDS

b)

OPIOID ANALGESICS

c)

NARCOTIC ANLAGESICS

d)

MILD ANALGESICS

55.

Leu- Enkephalin is Also known as (pentapeptide methionine- enkephalin). Met- Enkephalinis Also known as (eucine- enkephalin)

a)

1st correct

b)

2nd correct

c)

bith correct

d)

both wrong

56.

analgesia, bradycardia, and sedation

a)

MU 1

b)

MU 2

57.

respiratory depression, euphoria, and physical dependence

a)

MU 1

b)

MU 2

58.

endorphins

a)

mu

b)

kappa

c)

delta

d)

sigma

e)

orl receptor

59.

dynorphins

a)

mu

b)

kappa

c)

delta

d)

sigma

e)

orl receptor

60.

common in women

a)

mu

b)

kappa

c)

delta

d)

sigma

e)

orl receptor

61.

enkephalins

a)

mu

b)

kappa

c)

delta

d)

sigma

e)

orl receptor

62.

aka nociceptin receptor

a)

mu

b)

kappa

c)

delta

d)

sigma

e)

orl receptor

63.

central modulation of pain

a)

mu

b)

kappa

c)

delta

d)

sigma

e)

orl receptor

64.

reserve in the management of severe pain

a)

Analgesic

b)

Acute Pulmonary Edema

c)

Applications in Anesthesia

65.

Prototype opioid analgesic

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

66.

is the golden standard among opioid analgesics to which the structure and strengths of all other drugs are compared

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

67.

Poor bioavailability (pref. administered IV or rectal suppository)

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

68.

Very strong pain reliever but also very addictive

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

69.

Management of acute pulmonary edema

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

70.

Diacetylmorphine, diamorphine

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

71.

Incredibly addictive (MOST addicting)

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

72.

sold as cough suppressant and pain killer (10x stronger than morphine)

a)

HEROIN

b)

METHADONE

c)

MEPERIDINE

d)

FENTANYL

73.

binds to the μ receptor

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

74.

Greater oral efficacy, longer duration, less rapid development of tolerance

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

75.

Given in patients addicted to morphine or heroin- It is used for controlled withdrawal from heroin & morphine.

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

76.

Valdecoxib

a)

Celebrex, Celcox

b)

Mobic

c)

arcoxia

d)

Vioxx

e)

Bextra

77.

Dolophine®

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

78.

Demerol®

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

79.

synthetic opioid & shortest duration of analgesia

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

80.

a.k.a. “Pethidine”

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

81.

Preferred for analgesia during labor

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

82.

Causes: Antimuscarinic effect (reverse DUMBELS effect) contraindicated if tachycardia would be a problem)

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

83.

Derivative: Loperamide (Diatabs, Lomotil)

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

84.

(Available as patch) cannot be used in nonambulatory patients

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

85.

+ heroin (fat soluble) produce intense “rush” of euphoria

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

86.

With droperidol = dissociative anesthesia

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

87.

100x potent than morphine (analgesic)

a)

LEVORPHANOL

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

88.

is a synthetic opioid analgesic closely resembling morphine in its action

a)

LEVORPHANOL

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

89.

Optical isomer of dextromethorphan (less addicting isomer w/ anti-tussive effect)

a)

LEVORPHANOL

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL

90.

(cough depressant potency is 1/4 of morphine)

a)

CODEINE

b)

PROPOXYPHENE HCL

c)

OXYCODONE & HYDROCODONE

d)

DIPHENOXYLATE

91.

Analgesic potency is 1/12 of morphine

a)

CODEINE

b)

PROPOXYPHENE HCL

c)

OXYCODONE & HYDROCODONE

d)

DIPHENOXYLATE

92.

Less sedating and addicting

a)

CODEINE

b)

PROPOXYPHENE HCL

c)

OXYCODONE & HYDROCODONE

d)

DIPHENOXYLATE

93.

3-methyl ether of morphine

a)

CODEINE

b)

PROPOXYPHENE HCL

c)

OXYCODONE & HYDROCODONE

d)

DIPHENOXYLATE

94.

Metabolized by CYPD2D6 and demthylation--> Morphine

a)

CODEINE

b)

PROPOXYPHENE HCL

c)

OXYCODONE & HYDROCODONE

d)

DIPHENOXYLATE

95.

Derivative of methadone

a)

CODEINE

b)

PROPOXYPHENE HCL

c)

OXYCODONE & HYDROCODONE

d)

DIPHENOXYLATE

96.

Dextro – analgesic; Levo – antitussive

a)

true

b)

false

97.

Combinations of hydrocodone or oxycodone with acetaminophen are the predominant formulations of orally administered analgesics for the treatment of mild to moderate pain

a)

OXYCODONE & HYDROCODONE

b)

Lomotil-combined w/ Atropine

98.

Is a strong κ receptor agonist and a μ receptor antagonist.

a)

NALBUPHINE

b)

BUPRENORPHINE

c)

NALMEFENE

d)

TRAMADOL

99.

Antidiarrheal drug- used in combination with atropine (reduce addicting potential)

a)

DIPHENOXYLATE

b)

OXYCODONE (Oxycontin) & HYDROCODONE

c)

PROPOXYPHENE HCL

d)

NALOXONE

100.

Is a strong κ receptor agonist and a μ receptor antagonist.

a)

Nubain

b)

Buprenex

c)

ULTRAM®

d)

REVEX

101.

This agent is a partial agonist at μ receptors producing morphine-like effects in naïve users but precipitating withdrawal in morphine dependents.

a)

NALBUPHINE

b)

BUPRENORPHINE

c)

NALMEFENE

d)

TRAMADOL

102.

This agent is a partial agonist at μ receptors producing morphine-like effects in naïve users but precipitating withdrawal in morphine dependents.

a)

Nubain

b)

Buprenex

c)

ULTRAM®

d)

REVEX

103.

Its main use is in opioid detoxification as its withdrawal syndrome appears less severe and of shorter duration than methadone.

a)

Nubain

b)

Buprenex

c)

ULTRAM®

d)

REVEX

104.

Its main use is in opioid detoxification as its withdrawal syndrome appears less severe and of shorter duration than methadone.

a)

NALBUPHINE

b)

BUPRENORPHINE

c)

NALMEFENE

d)

TRAMADOL

105.

It is central-acting analgesic whose mechanism of action is predominantly based on enhanced serotonergic transmission

a)

NALBUPHINE

b)

BUPRENORPHINE

c)

NALMEFENE

d)

TRAMADOL

106.

It also inhibits norepinephrine transport function and is a weak μ receptors agonist, since it is only partially antagonized by naloxone.

a)

NALBUPHINE

b)

BUPRENORPHINE

c)

NALMEFENE

d)

TRAMADOL

107.

It is central-acting analgesic whose mechanism of action is predominantly based on enhanced serotonergic transmission.

a)

Nubain

b)

Buprenex

c)

ULTRAM®

d)

REVEX

108.

It also inhibits norepinephrine transport function and is a weak μ receptors agonist, since it is only partially antagonized by naloxone.

a)

Nubain

b)

Buprenex

c)

ULTRAM®

d)

REVEX

109.

is a decrease in response to the effects of the drug requiring even larger doses to achieve the same effects.

a)

Tolerance

b)

Physical Dependence

c)

Psychologic Dependence

110.

is the occurrence of a characteristic withdrawal or abstinence syndrome when the drug is stopped or an antagonist is administered.

a)

Tolerance

b)

Physical Dependence

c)

Psychologic Dependence

111.

a state of compulsive drug seeking behavior for personal satisfaction.

a)

Tolerance

b)

Physical Dependence

c)

Psychologic Dependence

112.

Opioid triad of toxicity/ overdose: EXCEPT

a)

Coma

b)

Pinpoint pupils

c)

Respiratory depression

d)

bradycardia

113.

used to reverse the coma and respiratory depression associated with opioid overdose.

a)

NALOXONE

b)

NALMEFENE

c)

ALVIMOPAN

d)

CAPSAICIN

114.

methylnaltrexone bromide (Relistor) for the treatment of constipation in patients with late-stage advanced illness

a)

NALOXONE

b)

NALMEFENE

c)

ALVIMOPAN

d)

CAPSAICIN

115.

The newest agents derivative of naltrexone but is available only for intravenous administration.

a)

NALOXONE

b)

NALMEFENE

c)

ALVIMOPAN

d)

CAPSAICIN

116.

it has longer half-life of 8-10 hours.

a)

NALOXONE

b)

NALMEFENE

c)

ALVIMOPAN

d)

CAPSAICIN

117.

peripherally acting μ-opioid receptor antagonist

a)

NALOXONE

b)

NALMEFENE

c)

ALVIMOPAN

d)

CAPSAICIN

118.

for the treatment of postoperative ileus following bowel resection surgery

a)

NALOXONE

b)

NALMEFENE

c)

ALVIMOPAN

d)

CAPSAICIN

119.

it has longer half-life of 8-10 hours.

a)

ENTEREG

b)

REVEX

c)

NARCAN

d)

CAPSAICIN

120.

used to reverse the coma and respiratory depression associated with opioid overdose.

a)

ENTEREG

b)

REVEX

c)

NARCAN

d)

CAPSAICIN

121.

peripherally acting μ-opioid receptor antagonist

a)

ENTEREG

b)

REVEX

c)

NARCAN

d)

CAPSAICIN

122.

for the treatment of postoperative ileus following bowel resection surgery

a)

ENTEREG

b)

REVEX

c)

NARCAN

d)

CAPSAICIN

123.

Brand: Zostrix®  From cayenne peppers It is topical indicated for post-herpetic neuralgia, neuropathic pain

a)

ENTEREG

b)

REVEX

c)

NARCAN

d)

CAPSAICIN

124.

Inhibit Substance P at nerve fibers

a)

NALOXONE

b)

NALMEFENE

c)

ALVIMOPAN

d)

CAPSAICIN

125.

burning sensation at site of application

a)

NALOXONE

b)

NALMEFENE

c)

ALVIMOPAN

d)

CAPSAICIN

126.

Activation of TRPV1 (transient receptor potential cation channel subfamily V) which provides a sensation of scalding heat

a)

NALOXONE

b)

NALMEFENE

c)

ALVIMOPAN

d)

CAPSAICIN

127.

Demerol®

a)

MORPHINE

b)

HEROIN

c)

METHADONE

d)

MEPERIDINE

e)

FENTANYL