Which of the following chromosome abnormalities is associated with CML?

A patient has a platelet count of 700 X 109 /L with abnormalities in the size, shape, and granularity of platelets; a WBC count of 12 X 109 /L; and hemoglobin of 11 g/dL. The Philadelphia chromosome is not present. The most likely diagnosis is

The peripheral blood in PV typically manifests:

The most common mutation found in patients with primary PV is:

A patient in whom CML has previously been diagnosed has circulating blasts and promyelocytes that total 30% of leukocytes. The disease is considered to be in what phase?

A patient has a WBC count 30 X 10^9 /L and the following WBC differential count:

Segmented neutrophils - 38%

Bands - 17%

Metamyelocytes - 7%

Promyelocytes - 10%

Eosinophils - 3%

Basophils - 5%

Which of the following test results would be helpful in determining whether the patient has CML?

Complications of ET include all of the following except:

Which of the following patterns is characteristic of the peripheral blood in patients with PMF?

this mutation is observed in 50% to 60% of patients with ET and PMF and contributes to the pathogenesis of the disorders

The myelofibrosis associated with PMF is a result of:

no longer considered an MPN and is divided into three subcategories

is currently treated with phlebotomy, hydroxyurea, and low-dose aspirin; and in the future JAK2 inhibitors will be a treatment alternative.

Approximately 4% of CML patients given ______ as firstline therapy develop imatinib resistance.