Worksheets8/14 PALS Session (Rahul & Saad)
Total questions: 10
Worksheet time: 2hrs 40mins
What single strand DNA repair mechanism is defective in xeroderma pigmentosum?
Base excision repair
Nucleotide excision repair
Mismatch repair
Homologous recombination
True or False: DNA polymerase III and I are only in prokaryotes
True
False
Which of the following is FALSE about chromatin?
Found in nucleus of eukaryotic cells
Chromatin condenses into chromosomes
Histones have negative charge (acidic amino acids)
H1 histone creates and stabilizes condensed chromatin
Which of these embryonic genes is responsible for segmental organization in cranial-caudal direction & transcription factor coding?
Sonic Hedgehog Gene (SHH)
Wnt-7 gene
Fibroblast growth factor (FGF) gene
Homeobox (Hox) genes
How many chromosomes are there in each cell after Meiosis I?
46
23
92
72
What clinical manifestation can HOX gene mutations (HOXA1, HOXB1, etc) cause?
Holoprosencephaly
Polydactyly/ Syndactyly
Hyperpigmented macules
Diarrhea & blood in stool
Purpose of cholesterol in plasma membrane
At high temperature, it keeps membrane fluid
At low temperature, it keeps membrane fluid
At high temperature, it keeps membrane neutral
At low temperature, it keeps membrane stiff
Which of these is variable expressivity?
Patients with the same genotype have varying phenotypes
Not all individuals with a disease show the disease
One gene contributes to multiple phenotypic effects
Increased severity or earlier onset of disease in succeeding generations
Which ion has a higher concentration inside the cell (contributes to the resting membrane potential)?
Which transport allows larger molecules/polar molecules to move across the cell membrane using channels and carrier proteins?
Osmosis
Facilitated Diffusion
Primary active transport
Secondary active transport
