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Basics of Developmental Biology

Total questions: 18

Worksheet time: 14mins

Name
Class
Date
1.

Fusion of precursor cells is an essential phenomenon in development of

a)

Nerve

b)

Skeletal Muscle

c)

Spleen

d)

Liver

2.

Homeotic genes are responsible for

a)

Development of anatomical structures

b)

Homeostasis

c)

Cell Cycle regulation

d)

Adaption to stress

3.

The first organ to develop during organogenesis is the

a)

Integumentary system

b)

Respiratory System

c)

Excretory System

d)

Cardiovascular System

4.

Homeotic genes are responsible for

a)

Maintaining gaps in segments

b)

Provide gradient for anterior posterior axis of embryo

c)

Codes secretory morphoges

d)

Formation of organ at defined locations

5.

Mosaic developmental pattern is always

a)

Autonomous

b)

Conditional

c)

Non autonomous

d)

Regulative

6.

The model organism to study cell lineage is

a)

Xenopus

b)

Yeast

c)

Caenorhabditis elegans

d)

Drosophila

7.

In regulative development, the prospective potency of cells

a)

Equal to prospective fate

b)

More than prospective fate

c)

Lesser than prospective fate

d)

Not determined

8.

The myxamoebae are in the vegetative stage where they feed on bacteria but enter the aggregation stage during nutrient starvation finally fruiting body with two types of differentiated cells. It is best example of evolution of

a)

Multicellularity

b)

Social behaviour

c)

Embryonic development

d)

Pattern formation

9.

Given are certain facts which define 'determination' of a developing embryo
A. Cells have made a commitment to a differentiation program
B. A phase where specific biochemical actions occur in embryonic cells

C. The cell cannot respond to differentiation signals

D. A phase where inductive signals trigger cell differentiation.

a)

B and C

b)

A and C

c)

Only A

d)

Only B

10.

Which one of the following development processes. In animals is more dependent on cellular movements?

a)

Pattern Formation

b)

Morphogenesis

c)

Cell differentiation

d)

Growth

11.

The pluripotency of the inner cell mass in mammals is maintained by a core of three transcription factors namely,

a)

Oct 4, Sox 2, and Nanog

b)

Oct 4, Sox 2, and Cdx2

c)

Sox2, Nanog and Cdx2

d)

Oct 4, Cdx2 and Nanog

12.

During development, if a cell has committed to a particular fate, it is said to be

a)

Pluripotent

b)

Totipotent

c)

Determined

d)

Differentiated

13.

Cell to Cell communication is important in development of an organism. The ability of cells to respond to a specific inductive signal is called

a)

Regional specificity of Induction

b)

Competence

c)

Juxtracrine signaling

d)

Instructive Interaction

14.

The ability of cells to achieve their respective fates by interacting with other cells is known as

a)

Autonomous specification

b)

Conditional specification

c)

Induction

d)

Competence

15.

The following are certain statements regarding stem cells

A. All types of stem cells have the ability to give rise to complete embryo

B. Multipotent stem cells are those whose commitment is limited to a relatively small subset of all possible cell types

C. Stem Cell niches allow controlled self-renewal and also survival of the cells that leave the niche

D. The pluripotency of the stem cells in an embryo is essentially maintained by Fgf8, Nanog and TGFb.
E. Adult cells may be reprogrammed to gain pluripotency by modifying the following genes: Oct 3/4, Sox2, c-myc, Klf-4
Which one of the following combinations of the statements is correct?

a)

A, B and D

b)

B and E

c)

C and E

d)

A, C and D

16.

The Cells of Inner Cell Mass of a blastocyst stage mammalian embryo are

a)

Totipotent

b)

Pluripotent

c)

Multipotent

d)

Unipotent

17.

Certain proteins or mRNAs that are regionally localized within the unfertilized egg and regulate development are called

a)

Gene regulators

b)

Morphometric determinants

c)

Cytoplasmic determinants

d)

Mosaic forming factors

18.

The embryonic stem cells in mammals are derived from

a)

Blastocoel

b)

Inner Cell Mass

c)

Trophoectoderm

d)

Trophoendoderm