WorksheetsY5 IM CONNECTIVE TISSUE DISEASE
Total questions: 5
Worksheet time: 4mins
Systemic sclerosis (scleroderma) affects
Skin
Internal organs (lungs, heart, kidney, GI)
Salivary & lacrimal glands
Vasculature
Smooth muscle
Skin involvement restricted to sites distal to elbow or knee (apart from face) + CREST syndrome is classified as
Limited cutaneous systemic sclerosis
Diffuse cutaneous systemic sclerosis
Pathophysiology of scleroderma
Environment trigger: silica dust, epoxy resin, vinyl chloride
Genetic component associate with allels at HLA locus
Environment trigger: UV light, viruses, heavy metals
T lymphocytes (Th17 subtype) infiltrate the skin
CREST syndrome
Esophageal dysmotility
Raynaud's phenomenon
Calcinosis
Sclerodactyly (thickening & tightening of skin on hands and fingers)
Telangiectasia
State 2 scleroderma features you see in the picture
(a)
