Worksheets2024MAR20 FordhamUni
Total questions: 8
Worksheet time: 5mins
Microglia originates from which germ layer?
Ectoderm
Mesoderm
Endoderm
Which similarities do microglia share with blood macrophages?
Select all that apply:
Phagocytic capacity
Cytokine release
Ontogeny
Antigen presentation
What tests can be performed to determine the "activation" of microglia?
Select all that apply.
ELISA
(Enzyme-linked immunosorbent assay)
PCR
(Polymerase chain reaction)
Biomarkers expression
Morphology analysis
Flow cytometry
Monocytes and macrophages are continuously being replaces throughout adulthood from bone marrow-derived precursors, while microglia are a long-lived population that self-renews in the healthy CNS, with no peripheric contribution on their turnover.
True
False
Select the WRONG statement:
Microglia are the tissue-resident macrophages of the CNS
Microglia is part of the innate immune response of the CNS
Microglia is considered surveillant in homeostatic conditions
The blood-brain barrier prevents all interactions between microglia and the peripheric immune system
Microglia are the main antigen-presenting cells inside the brain parenchyma
Which of the following is a primary function of microglia in the CNS?
Myelination of central nervous system neurons
Regulation of blood-brain barrier permeability
Phagocytosis of pathogens and debris
Production of cerebrospinal fluid
During neuroinflammation, microglia can transform into an activated state. Which of the following is NOT a characteristic of this activated state?
Increased phagocytic activity
Release of pro-inflammatory cytokines
Enhanced production of neurotrophic factors
Decreased motility and surveillance capability
Which statement accurately describes the relationship between microglia and astrocytes in the CNS?
Microglia and astrocytes are both derived from mesodermal germ layer
Microglia, but not astrocytes, can act as antigen-presenting cells
Astrocytes, but not microglia, form the blood-brain barrier
Both microglia and astrocytes are incapable of releasing cytokines
