WorksheetsDay 3 Recap Lyumjev Quiz
Total questions: 20
Worksheet time: 7mins
Name
Class
Date
1.
Higher post prandial glucose levels are observed in Indian T2DM patients mainly due to:
a)
Fat rich diet
b)
Protein rich diet
c)
Carbohydrate rich diet
d)
All of the above
2.
In the first 15 min after dosing, increase in exposure shown by URLi was:
a)
2 folds vs. fiasp
b)
1.5 folds vs. fiasp
c)
5 folds vs. insulin aspart
d)
both b & c
3.
How long does the post prandial state last after a meal?
a)
2 h
b)
4 h
c)
≤6 h
d)
4-6 h
4.
Mismatch between insulin action and PPG elevations does not affect HbA1c control:
a)
True
b)
False
5.
URLi is a novel, prandial insulin lispro formulation that includes following excipients:
a)
niacinamide & treprostinil
b)
treprostinil & citrate
c)
treprostinil & lispro
6.
On an average, what proportion of a day does an individual spend in post prandial state?
a)
≥50%
b)
≥60%
c)
≤40%
d)
80-90%
7.
Hypoglycaemia is less in patients who dose rapid-acting insulins:
a)
Before meals
b)
At meal-time
c)
After meals
d)
both a & b
8.
In the pharmacokinetic and glucodynamic study of URLi versus Fiasp, Humalog and NovoRapid in patients with T1D, choose the correct sentence/s:
a)
Fiasp showed fastest insulin absorption
b)
URLi showed greatest early insulin exposure
c)
Fiasp showed greatest early insulin exposure
d)
URLi showed fastest insulin absorption and greatest early insulin exposure
9.
The TIR metrics include:
a)
time above range
b)
time below range
c)
time in range
d)
all of the above
10.
Local vasodilation & increased vascular permeability are actions shown respectively by
a)
niacinamide & treprostinil
b)
treprostinil & citrate
c)
treprostinil & lispro
d)
treprostinil & L-arginine
11.
As per Phase 1 PK PD study, compared to rapid acting analog (lispro), URLi showed:
a)
5-minutes faster appearance in serum
b)
8-fold higher insulin exposure in the first 15 minutes after injection
c)
10-minute earlier onset of action
d)
All of the above
12.
Current rapid acting insulins focus mainly on 1 h and 2 h PPG control.
a)
False
b)
True
13.
The ideal target range of blood glucose in diabetes patients is
a)
100-180 mg/dL
b)
70-180 mg/dL
c)
90-140 mg/dL
d)
90-180 mg/dL
14.
After meal, which timepoints should be focussed on for PPG control?
a)
1 & 2 h
b)
3 & 4 h
c)
5 & 6 h
d)
Both a & b
e)
All of the above
15.
According to ADA recommendations, the time spent in the target range should be:
a)
≥50%
b)
≥70%
c)
<80%
d)
>70%
16.
In PRONTO -T1D and PRONTO-T2D, mealtime URLi was ------------------------- to rapid acting insulin analog (RAA) in controlling PPG excursions:
a)
non-inferior
b)
superior
c)
inferior
17.
In PRONTO -T1D and PRONTO-T2D, mealtime URLi was ------------------------- to RAA in controlling HbA1c:
a)
non-inferior
b)
superior
c)
inferior
18.
In PRONTO -T1D and PRONTO-T2D trials, compared to RAA mealtime, mealtime URLi showed:
a)
reduced risk of hypoglycemia
b)
increased risk of hypoglycemia
c)
no increase in risk of hypoglycemia
19.
In PRONTO -T1D CGM substudy, compared with mealtime lispro, mealtime URLi provided:
a)
additional 100 min of daytime TIR
b)
50 min less of daytime TIR
c)
additional 44 min of daytime TIR
d)
44 min less of daytime TIR
20.
In PRONTO trials, URLi has shown greater reductions in postprandial glucose excursions up to _____ hour/hours
a)
1
b)
2
c)
3
d)
4
100 %
