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WorksheetsMetabolism and Excretion
Total questions: 10
Worksheet time: 6mins
Which statement is true regarding first-pass metabolism?
Metabolism that occurs before absorption
Metabolism that occurs before distribution
Metabolism that occurs after distribution
Metabolism that occurs after excretion
Metabolism that occurs before elimination
A prodrug is a drug formulation that is inactive, thus it can directly provide an effect after administration
true
false
Phase 1 metabolism is largely performed by CYP 450 enzymes.
true
false
If an active drug (A) is consumed together with another drug (B) that acts as an enzyme inducer of CYP 450, what will happen?
drug A will accumulate in the blood
drug A will have toxic effects
many metabolites of drug B will be formed
the effect of drug B will increase
the amount of drug A at the site of action decreases
Paracetamol undergoes phase 1 metabolism and is converted to NAPQI, which is normally further metabolized in phase 2 by conjugation with GSH, resulting in a toxic metabolite.
true
false
Drugs will be filtered through the glomerulus using:
passive diffusion
facilitated diffusion
active transport
endocytosis
pinocytosis
Weak acid drugs will be eliminated from the body when
the urine pH is acidic, so many drugs are reabsorbed
the urine pH is acidic, so many drugs are not ionized
the urine pH is basic, so many drugs are ionized
the urine pH is basic, so many drugs are non-polar
the urine pH is acidic, so many drugs are trapped in the urine
Drugs that are polar will mostly reach the kidneys through
glomerular filtration
active secretion in the proximal tubule
reabsorption in the distal tubule
The range of therapy is
duration of drug effect
the time required to produce an effect since the drug is given
the amount and time the drug is in systemic circulation
minimum effective concentration
the distance between KEM and KTM
The drug that is excreted through feces is a drug that cannot be absorbed and a drug that binds with bile.
true
false
