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Blood Cell Formation and Development

Total questions: 10

Worksheet time: 50secs

Name
Class
Date
1.

The process of formation and development of blood cells is termed:

a)

Hematopoiesis

b)

Hematocrit

c)

Hematology

d)

Hematoma

2.

During the second trimester of fetal development, the primary site of blood cell production is the:

a)

Bone marrow

b)

Spleen

c)

Lymph nodes

d)

Liver

3.

Which one of the following organs is responsible for the maturation of T lymphocytes and regulation of their expression of CD4 and CD8?

a)

Spleen

b)

Thymus

c)

Liver

d)

Bone marrow

4.

The best source of active bone marrow from a 20 year old would be:

a)

Femur

b)

Iliac crest

c)

Distal radius

d)

Tibia

5.

Which organ is the site of sequestration of platelets?

a)

Bone marrow

b)

Liver

c)

Thymus

d)

Spleen

6.

Which one of the following morphologic changes occurs during normal blood cell maturation?

a)

Condensation of nuclear chromatin

b)

Increase in cell diameter

c)

Development of cytoplasm basophilia

d)

Nuclear fragmentation

7.

What is the primary function of erythrocytes?

a)

Hormone regulation

b)

Oxygen transport

c)

Immune response

d)

Blood clotting

8.

What is the lifespan of a typical platelet?

a)

100 days

b)

40 days

c)

7 days

d)

10 days

9.

Which one of the following cytokines is required very early

in the differentiation of a hematopoietic stem cell?

a)

IL-2

b)

IL-8

c)

EPO

d)

FLT3 ligand

10.

When a patient has severe anemia and the bone marrow is

unable to effectively produce red blood cells to meet the

increased demand, one of the body’s responses is:

a)

Increased proportion of yellow marrow in the long

bones

b)

Decreased production of erythropoietin by the kidney

c)

Extramedullary hematopoiesis in the liver and spleen

d)

Increased apoptosis of erythrocyte progenitor cells