Worksheetsimmunological tolerance and autoimmunity
Total questions: 15
Worksheet time: 8mins
What does CTLA-4 do?
Prevents T cell activation
Activates T cells
Increases IL-2
Stimulates apoptosis
Which cells are known as Tregs?
CD4+CD25+FoxP3+ cells
CD8+ cells
B cells
NK cells
What is the role of IL-10?
Suppresses lymphocytes
Activates macrophages
Stimulates apoptosis
Promotes T cell growth
What triggers apoptosis in T lymphocytes?
Increased IL-2
Pro-apoptotic protein formation
CTLA-4 activation
IL-10 secretion
What does PD-1 stand for?
Programmed death protein-1
Primary death protein-1
Proliferation death protein-1
Peripheral death protein-1
What is the function of TGF-beta?
Stimulates IL-2 production
Suppresses immune response
Activates T cells
Promotes cell division
What is Fas (CD95)?
A type of B cell
A cytokine
A receptor that triggers apoptosis
A type of T cell
What happens when IL-2 is depleted?
B cells are activated
T cells grow faster
Apoptosis is prevented
T cell activation is reduced
What does the term 'receptor balance' refer to?
The balance of activating and inhibitory signals
The number of T cells in the body
The amount of IL-2 produced
The types of lymphocytes present
What is the role of caspases?
Promote cell growth
Trigger apoptosis
Activate T cells
Suppress immune response
Which cytokine is important for Treg function?
IL-12
IL-6
IL-2
IL-1
What does the expression of inhibitory receptors do?
Activates T cells
Inhibits T cell activation
Stimulates IL-10 production
Promotes apoptosis
What is the effect of increased co-expression of death receptors?
Decreased immune response
Increased IL-2 production
Increased apoptosis
Increased T cell activation
What is the function of CD28 family receptors?
Promote apoptosis
Activate T cells
Suppress immune response
Inhibit T cell activation
What does 'depletion of IL-2' refer to?
Increased T cell growth
Reduced T cell activation
Increased apoptosis
Enhanced immune response
