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Development of the Nervous System

Total questions: 14

Worksheet time: 11mins

Name
Class
Date
1.

At what stage of development are the three germ layers formed?

a)

Cleavage

b)

Blastulation

c)

Gastrulation

d)

Organogenesis

2.

What is the primary structure through which epiblast cells migrate during gastrulation?

a)

Neural groove

b)

Primitive streak

c)

Notochord

d)

Somites

3.

Which germ layer forms the nervous system?

a)

Endoderm

b)

Mesoderm

c)

Ectoderm

d)

Hypoblast

4.

What structure is formed by epiblast cells displacing the hypoblast during gastrulation?

a)

Mesoderm

b)

Endoderm

c)

Neural plate

d)

Ectoderm

5.

What is the role of the notochord in embryonic development?

a)

Formation of somites

b)

Neural tube closure

c)

Apoptosis regulation in neural structures

d)

Formation of Vertebra column

6.

During an embryology class, Thomas learned about a condition that results from the failure of the cranial neural tube to close. Which of these best describes this condition?

a)

Spina bifida

b)

Anencephaly

c)

Hydrocephalus

d)

Lissencephaly

7.

Grace is studying different types of spina bifida for and read about the mildest form of spina bifida. Which is it?

a)

Meningocele

b)

Myelomeningocele

c)

Myeloschisis

d)

Occulta

8.

The closure of the rostral neuropore leads to the formation of which primary brain vesicles?

a)

Telencephalon, diencephalon, myelencephalon

b)

Prosencephalon, mesencephalon, rhombencephalon

c)

Telencephalon, diencephalon, mesencephalon

d)

Mesencephalon, metencephalon, myelencephalon

9.

What brain condition involves disruptions in neural migration resulting in a smooth brain?

a)

Hydrocephalus

b)

Spina bifida

c)

Lissencephaly

d)

Myelomeningocele

10.

Which structure is an adult derivative of the notochord?

a)

Intervertebral discs

b)

Vertebral column

c)

Nucleus pulposus

d)

Meninges

11.

A 9-month-old infant presents with progressive motor delay, spasticity, and hyperreflexia. Neurological examination reveals increased tone in the lower limbs and brisk deep tendon reflexes. Brain imaging shows diffuse white matter abnormalities. He was later diagnosed with a demyelinating disorder in the CNS.
What cell type is responsible for myelination in the central nervous system?

a)

Astrocytes

b)

Oligodendrocytes

c)

Schwann cells

d)

Microglial cells

12.

A 10-month-old infant is brought to the clinic with delayed motor milestones, hypotonia, and reduced reflexes. Nerve conduction studies reveal significantly slowed conduction velocities.
Family history reveals a sibling with similar symptoms in infancy. Genetic testing confirms a diagnosis of an inherited demyelinating neuropathy.
What cell type is responsible for myelination in the peripheral nervous system?

a)

Ependymal

b)

Oligodendrocytes

c)

Schwann cells

d)

Microglial cells

13.

Anaya is expecting her first child and wants to ensure she is getting the right nutrients to support her baby's development. Which nutrient is critical in reducing neural tube defects?

a)

Vitamin C

b)

Iron

c)

Calcium

d)

Folic acid

e)

Vitamin D

14.

The failure of the neural tube to close completely leads to defects such as spina bifida and anencephaly. Which part of the neural tube fails to close in spina bifida?

a)

Middle part of the neural tube

b)

Caudal part of the neural tube

c)

Rostral part of the neural tube

d)
Entire neural tube fails to close