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Mutation Sickle Cell Anemia

Total questions: 16

Worksheet time: 8mins

Name
Class
Date
1.

What protein is affected by sickle cell disease?

a)

Red Blood Cells

b)

Hemoglobin

c)

White Blood Cells

d)

DNA

2.

Which combination would result in a 50% chance of having sickle cell disease?

a)

SS + SS

b)

Ss + SS

c)

Ss + ss

d)

Ss + Ss

3.

Why do sickle cell anemia patients experience pain?

a)

Sickled red blood cells cause blockages

b)

The sickled blood cells are carried throughout the body to fast

c)

Sickled blood cells attack normal blood cells

d)

There is a lower number of white blood cells

4.

Where are the most sickle cell anemia patients located?

a)

Up North

b)

In the South

c)

Around the Equator

d)

In China

5.

Why does sickle cell disease occur more often near the equator?

a)

Humidity makes it more likely to pass on

b)

Sickle cell disease provides defense against pellagra

c)

Sickle cell disease provides defense against malaria

d)

It's just random chance

6.

What are treatment(s) for sickle cell anemia?

a)

Blood Transfusion

b)

Hydroxyurea

c)

Bone Marrow Transplant

d)

All of the Above

7.

What chromosome does sickle cell disease affect?

a)

Chromosome 12

b)

Chromosome 11

c)

Chromosome 2

d)

Chromosome 21

8.

Is person I-1 a carrier?

a)

Yes

b)

No

9.

Person II-5 is not a carrier of sickle cell anemia

a)

True

b)

False

10.

If person III-1 was to have a child with a carrier, what is the probability of that child having sickle cell anemia?

a)

50%

b)

100%

c)

75%

d)

25%

11.

A person with normal RBC's wants to have a child with a patient that has sickle cell disease. What is the probability of the child having sickle cell anemia?

a)

15%

b)

50%

c)

0%

d)

100%

12.

Which combination would result in a 100% chance of a child with sickle cell disease?

a)

Ss + Ss

b)

ss + ss

c)

Ss + ss

d)

SS + SS

13.

A patient's mother had sickle cell disease. The patient does not, and is marrying someone with normal RBC's. What is the probability that that child will be a carrier?

a)

25%

b)

0%

c)

100%

d)

50%

14.

What process describes the change in amino acids in a sickle cell RBC?

a)

Deletion

b)

Substitution

c)

Insertation

d)

None of the Above

15.

What type of amino acid is replaced by substitution in a sickle cell RBC?

a)

Glutamic Acid

b)

Histidine

c)

Leucine

d)

Valine

16.

What amino acid replaces another by substitution in a sickle cell RBC?

a)

Glutamic Acid

b)

Histidine

c)

Leucine

d)

Valine