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WorksheetsAP Biology DNA, RNA Protein Synthesis
Total questions: 21
Worksheet time: 12mins
Name
Class
Date
1.
What is the corresponding codon for AGT?
a)
UCA
b)
TCA
c)
UGA
d)
ACU
2.
Which description of nucleotide triplets best represents a codon?
a)
a triplet separated spatially from other triplets
b)
a triplet that has no corresponding amino acid
c)
a sequence of tRNA at the 3' end
d)
a triplet in the same reading frame as an upstream AUG
3.
Which of the following does not occur in prokaryotic gene expression but does occur in eukaryotic gene expression?
a)
mRNA, tRNA, and rRNA are transcribed
b)
RNA polymerase binds to the promotor
c)
a poly-A tail is added to the ends of the mRNA
d)
Transcription can begin as soon as translation has begun even alittle
4.
Transcription in eukaryotes requires which of the following in addition to RNA polymerase?
a)
the protein product of the promotor
b)
start and stop codons
c)
ribosomes and tRNA
d)
several transcription factors
5.
Which of the follwoing best describes the significance of the TATA box in eukaryotic promoters?
a)
it is the recognition site for a specific transcription factor
b)
it sets the reading frame of the mRNA
c)
it is the recognition site for ribosomal binding
d)
it signals the end of the nucleotide sequence of the gene
6.
RNA polymerase moves in which direction along the DNA?
a)
5' to 3'
b)
3' to 5' along the template strand
c)
3' to 5' along nontemplate(coding) strand
d)
5' to 3' along the template strand
7.
What is the function of the poly-A tail in mRNA?
a)
to add modified guanin to the 3' end of the mRNA
b)
to indicate the site of translational termination
c)
to code for the binding of RNA polymerase to the DNA
d)
to help protect the mRNA from degradation by hydrolytic enzymes
8.
What is a ribozyme?
a)
enzyme that uses RNA as a substrate
b)
RNA with enzymatic activity
c)
an enzyme that catlyzes the association between the large and small ribosomal subunits
d)
an enzyme tha synthesizes RNA primers during DNA replication
9.
When the spliceosome binds to a pre-mRNA transcript, where does it typically attach?
a)
to the exons
b)
to the 5'UTR
c)
to the 3'UTR
d)
at certain sequences along an intron
10.
What is the anticodon on the tRNA that binds to mRNA codon for the DNA coding sequence AAA?
a)
TTT
b)
UUU
c)
UUA
d)
AAA
11.
What is the function of GTP?
a)
provide energy for formation of the initiation complex, using initiation factors
b)
UUU
c)
UUA
d)
AAA
12.
Accuracy in the translation of mRNA into the sequence of amino acids in a polypeptide depends on specificity in which of the following?
a)
binding of ribosomes to mRNA
b)
shape of the A and P sites of ribosomes
c)
attachment of amino acids to tRNAs
d)
bonding of the anticodon the codon and the attachment of amino acids to tRNAs
13.
Which of the following events in translation is the first to occur in eukaryotes?
a)
elongation of the polypeptide
b)
base pairing of activated methionine-tRNA to AUG of the messenger RNA
c)
binding of the larger ribosomal subunit to smaller ribosomal subunits
d)
the small subunit of the ribosome recognizing and attaching to the 5'cap
14.
What is the function of the release factor in translation?
a)
it separates tRNA in the A site from the growing polypeptide
b)
it binds to the stop codon in the A site in place of a tRNA
c)
it releases the amino acid from its tRNA to allow the amino acid to form a polypeptide
d)
it releases the ribosome from the ER to allow polypeptides into the cytosol
15.
What must happen to a newly made polypeptide before it can be secreted from a cell?
a)
it must be translated by a ribosome that remains free of attachment to the ER
b)
its signal sequence must target it to the ER, after which it goes to the Golgi
c)
Its signal sequence must be cleaved off
d)
Its signal sequence must target it to the plasma membrane
16.
What is the effect of a nucleotide-pair substitution that results in a nonsense mutation in a gene?
a)
it changes an amino acid in the encoded protein
b)
It has no effect on the amino acid sequence of the encoded protein
c)
it introduces premature stop codon into the mRNA
d)
it alters the reading frame of the mRNA
17.
Which is the best description of a gene?
a)
a DNA sequence that is expressed to form a functional product; either RNA or polypeptide
b)
a DNA subunit that codes for a single complete protein
c)
a DNA-RNA sequence combination that results in an enzymatic product
d)
a descrete unit of hereditary information that consists of a sequence of amino acids
18.
A possible sequence of nucleotides in the template strand of DNA that would code for the polypeptide sequence phe-leu-ile-val would be?
a)
5'-TTG-CTG-CAG-TAG-3'
b)
3'-AAC-GAC-GUC-AUA-5'
c)
3'-AAA-AAT-ATA-ACA-5'
d)
3'-AAA-GAA-TAA-CAA-5'
19.
What amino acid sequence will be produced based on the mRNA codon sequence
5'-AUG-UCU-UCG-UUA-UCC-UUG-3'
5'-AUG-UCU-UCG-UUA-UCC-UUG-3'
a)
met-ser-leu-ser-leu-ser
b)
met-ser-ser-leu-ser-leu
c)
met-leu-phe-arg-glu-glu
d)
met-glu-arg-arg-glu-leu
20.
In transcription of DNA where is the promotor located?
a)
at the 3'end of the newly made RNA
b)
to the right of the template strand
c)
to the left of the template strand
d)
In the middle of the template strand
21.
A tRNA (#1) attached to the amino acid lysine enters the ribosome. The lysine binds to the growing polypeptide on the other tRNA (#2) already in the ribosome. Where does tRNA (#2 move to next?
a)
A site
b)
P site
c)
E site
d)
exit tunnel
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