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Biochemistry of Reproductive hormones

Total questions: 10

Worksheet time: 5mins

Name
Class
Date
1.

A disease caused by the mutation (loss-of-function) of GnRH receptor gene presents with?

a)

Hypogonadotropic hypogonadism

b)

Hypogonadotropic hypergonadism

c)

Hypergonadotropic hypogonadism

d)

Hypergonadotropic hypergonadism

2.

During embryological development, if GnRH neurons are defective in migration to the hypothalamus, which of the following most likely occurs?

a)

Loss of vision

b)

Loss of smell

c)

Loss of taste

d)

Loss of hearing

3.

A disease caused by excess GnRH release in childhood presents with?

a)

Delayed puberty

b)

Central precoccious puberty

c)

Peripheral precoccious puberty

d)

Primary amennorrhea

4.

A disease caused by increased frequency of GnRH pulse presents with?

a)

High LH

b)

High FSH

c)

High progesterone

d)

High chance of twin pregnancy

5.

A 46,XY fetus with the 100% mutation of androgen receptor gene was born. Which of the following most likely observed in this fetus.

a)

Normal male fetus

b)

Normal female fetus

c)

Male fetus with ambiguous genitalia

d)

Female fetus with ambiguous genitalia

6.

A 46,XY fetus with the the mutation of 5-alpha reductase gene was born. Which of the following most likely observed in this fetus.

a)

Normal male fetus

b)

Normal female fetus

c)

Male fetus with ambiguous genitalia

d)

Female fetus with ambiguous genitalia

7.

A fetal chromosome study from amniotic fluid examination revealed the mutation of AMHR2 gene that expresses anti-Müllerian hormone receptor. Which of the following is the most likely genotypic and phenotypic presentation of this male fetus?

a)

Normal male fetus

b)

Normal female fetus

c)

Male fetus with ambiguous genitalia

d)

Female fetus with ambiguous genitalia

8.

If serum progesterone level is high during the pre-ovulatory phase, which of the following is expected to occur?

a)

No ovulation

b)

Early ovulation

c)

Late ovulation

d)

Multiple ovulation

9.

What is the most concern adverse effects of hormonal replacement therapy in post-menopausal woman?

a)

Stroke

b)

Pathologic fructure of femur

c)

Coronary artery disease

d)

Breast cancer

10.

A 45-year-old woman with breast cancer receives an aromatase inhibitor as a treatment. Which of the following is/are most likely observed in this woman?

a)

Hor flushes and mood swing

b)

Thrombosis of femural vein

c)

Increased risk of uterine cancer

d)

Elevated serum hemoglobin and red cell number