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Kuis - ABF 2025

Total questions: 10

Worksheet time: 10mins

Name
Class
Date
1.

Here is a sample from humans that can be used in bioanalysis:

1. Urine

2.Sweat

3.Nails

4.Blood

5.Hair

Which of the following samples can be used to detect long-term drug abuse?

a)

1 and 2

b)

2 and 3

c)

3 and 5

d)

4 and 5

e)

1 and 5

2.

A study aims to evaluate the ability of a new drug based on its effects on the brain. Which of the following samples would be appropriate for use in this analysis?

a)

cerebrospinal fluid

b)

synovial fluid

c)

blood

d)

vitreous humor

e)

pericardium fluid

3.

A case of pleural effusion in a tuberculosis patient shows fluid identified as containing high levels of protein and lactate dehydrogenase, with a tendency to appear cloudy yellow. What is this type of fluid called?

a)

transudate

b)

exudate

c)

piopericardium

d)

hemopericardium

e)

pericardium effusion

4.

The following are biological samples that can be used in bioanalysis:

1.Urine

2. Sweat

3.Blood

4.Nails

5.Hair

In the case of a traffic accident, if it is necessary to confirm that a person is not under the influence of drugs or alcohol, which sample would be appropriate for analysis?

a)

1 and 2

b)

2 and 4

c)

3 and 4

d)

1 and 3

e)

4 and 5

5.

Which of the following statements is less appropriate to consider when conducting bioanalysis?

a)
  • The presence of other compounds that are also identified due to structural similarity

b)
  • Using a standard reference of the active pharmaceutical ingredient in a formulation to analyze the concentration of a prodrug's metabolite

c)
  • The decomposition of the drug in the sample due to enzymatic reactions

d)
  • The hydrolysis process of conjugated drug forms during metabolism

e)
  • Most synthetic drugs exist in racemic form

6.

Sample preparation for bioanalysis is an important step due to several aspects below, except:

a)

Eliminating the potential interfering components from the sample matrix

b)

obtaining more accurate results

c)

Concentrating the sample to enable detection

d)

Protecting the analytical instrument from potential damage

e)

Speeding up the detection process of the components to be analyzed

7.

The following statements are correct regarding the accelerated solvent extraction technique in bioanalysis, except

a)

Using a small amount of solvent

b)

Can be used for solid and semi-solid biological samples

c)

Minimizes sample exposure to solvents

d)

Uses Soxhlet extraction or sonication in the process

e)

Utilizes heating with an oven

8.

The following statements are consistent with ion exchange separation techniques for bioanalysis, except:

a)

The bond between the analyte and the sorbent is weak, making it easy to be eluted

b)

pH changes can be used in the separation process

c)

Analysis is based on the interaction between the sorbent and the sample in a solution with different charges

d)

Hydrophobic contaminants can be removed using an organic solvent

e)

The analyte to be analyzed must be in its ionic form

9.

The following are types of sorbents commonly used in ion-exchange chromatography:

1.aminopropyl

2.sulfonic acid

3.diethylamino

4.carboxylic acid

5.cellulose

Which one can be used for cation-exchange chromatography in bioanalysis?

a)

1 and 2

b)

3 and 4

c)

1 and 5

d)

4 and 5

e)

2 and 4

10.

The interactions between the sorbent in SPE and the analyte commonly found are as follows, except:

a)

van der Waals force

b)

hydrogen bond

c)

electrostatic attraction

d)

polar interaction

e)

covalent bond