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Gastric System Physiology

Total questions: 14

Worksheet time: 11mins

Name
Class
Date
1.

In a study of the secretion of gastrointestinal hormones, portal concentrations are measured in a rat during luminal perfusion of buffered salt solutions at various pH levels.  Which of the following hormones will increase during perfusion with a buffered solution at pH 3.0?

a)

Cholecystokinin

b)

Gastrin

c)

Glucose-dependent insulinotropic peptide

d)

Motilin

e)

Secretin

2.

Cholecystokinin (CCK) has some gastrin-like properties because both CCK and gastrin  

a)

Released from G cells in the stomach

b)

Released from I cells in the duodenum

c)

Members of the secretin-homologous family

d)

Have five identical C-terminal amino acids

e)

Have 90% homology of their amino acids

3.

A patient suffering from anemia comes to his physician complaining of frequent bouts of gastroenteritis. A blood test reveals the presence of antibodies directed against gastric parietal cells. The anemia in this patient is attributable to the hyposecretion of which gastric product?

a)

Histamine

b)

Gastrin

c)

Pepsinogen

d)

Intrinsic factor

e)

Hydrochloric acid

4.

Two medical students studying for their physiology exam decided to take a break for a lunchtime hamburger. Before reaching the cafeteria, nervous impulses from the dorsal vagal complex will initiate gastric acid secretion by triggering release of which neurotransmitter from the enteric nervous system?

a)

Norepinephrine

b)

Vasoactive intestinal polypeptide

c)

Substance P

d)

Gastrin-releasing peptide

e)

Nitric oxide

5.

A 3-year-old boy is brought to his pediatrician for an evaluation because of failure to thrive and frequent diarrhea characterized by pale, bulky, foul-smelling stools. Sweat chloride concentrations are measured and found to be elevated. Diminished secretion of which pancreatic product is most likely to be the primary cause of the patient’s apparent fat malabsorption?

a)

Lipase

b)

Procolipase

c)

Monitor peptide

d)

Cholecystokinin

e)

Bicarbonate

6.

A researcher conducts a study of the regulation of salivary secretion in a group of normal volunteers under various conditions. Which of the following conditions would be expected to be associated with the lowest rates of secretion?

a)

Chewing gum

b)

Undergoing a mock dental exam

c)

Sleep

d)

Exposure to a nauseating odor

e)

Resting control conditions

7.

A 50-year-old female patient who has suffered for several years from severe dryness of her eyes due to inadequate tear production is referred to a gastroenterologist for evaluation of chronic heartburn. Endoscopic evaluation reveals erosions and scarring of the distal esophagus. Reduced production of which salivary product most likely contributed to this tissue injury?

a)

Bicarbonate

b)

Lactoferrin

c)

IgA

d)

Mucus

e)

Amylase

8.

A newborn baby is brought to the pediatrician suffering from severe diarrhea that worsens after feeding. The symptoms diminish when nutrients are delivered intravenously. The child most likely has a mutation in which of the following intestinal transporters?

a)

Na+, K+ ATPase

b)

NHE3

c)

SGLT-1

d)

H+, K+ ATPase

e)

NKCC1

9.

An infant who was previously healthy but is displaying symptoms of acute diarrhea and dehydration after an infection is given an oral solution of glucose and electrolytes (Pedialyte). What membrane protein accounts for the ability of this solution to provide rapid hydration?

a)

Sucrase-isomaltase

b)

SGLT-1

c)

CFTR

d)

Chloride-bicarbonate exchanger

e)

Lactose-phlorizin hydrolase

10.

A 6 year old child was brought to her pediatrician exhibiting signs of malnutrition, diarrhea, and edema of the extremities. Duodenal aspirates were obtained at endoscopy after intravenous administration of cholecystokinin, and was found to be incapable of protein hydrolysis at neutral pH unless a trace amount of trypsin is added that by itself would not result in appreciable hydrolysis. The patient was most likely suffering from a deficiency in which of the following?

a)

Pepsinogen

b)

PepT1

c)

Trypsinogen

d)

Carboxypeptidases

e)

Enterokinase

11.

In infants, defecation often follows a meal. The cause of colonic contractions in this situation is:

a)

histamine

b)

increased circulating levels of CCK

c)

the gastrocolic reflex

d)

increased circulating levels of somatostatin

e)

the enterogastric reflex

12.

A patient who has undergone a partial gastric resection to remove a tumor reports to his primary care physician that he has experienced several episodes of nausea, cramping, dizziness, sweating and a rapid heart rate after ingesting sugary beverages. His symptoms are caused in part by

a)

increased blood pressure

b)

increased secretion of acid

c)

increased secretion of CCK

d)

hypoglycemia

e)

hyperglycemia

13.

A scientist studies the regulation of gastric motility by placing a pressure sensor in the stomach of a mouse that remotely reports intragastric pressure over time. She notes that gastric pressures seldom rise above the levels that breach the lower esophageal sphincter, even when the stomach is filled with a meal and its volume is expanded considerably as a result. Which process is responsible for this finding?

a)

Peristalsis

b)

Gastroileal reflex

c)

Segmentation

d)

Stimulation of the vomiting center

e)

Receptive relaxation

14.

A patient is referred to a gastroenterologist for evaluation of suspected small bowel bacterial overgrowth. Motility studies reveal slowed gastrointestinal transit during fasting. The patient’s symptoms are most likely due to a deficit in which of the following substances?

a)

Motilin

b)

NO

c)

CCK

d)

VIP

e)

Secretin