WorksheetsMP 180 B
Total questions: 14
Worksheet time: 12mins
Familly name // nom de famille
What is your team color ? // Quelle est la couleur de votre équipe ?
How many people are in the NMT team?
16
19
22
25
Which diseases the NMT team is studing in our research?
Charcot-Marie-Tooth disease
Dysferlinopathies
Emery-Dreiffus muscular dystrophy
Calpainopathies
What's the most common injury in our lab?
Water bath burns
Infected cells
fractured pipettes
mouse bites
broken dreams
What gene is mutated in Imane’s study?
PLEC1 gene
PCL1 gene
PLOS1 gene
PICKELS1 gene
What model does Imane use to study muscle cells?
Induced pluripotent stem cells differentiated into smooth muscle cells.
Induced pluripotent stem cells differentiated into skeletal muscle cells.
Induced totipotent stem cells differentiated into skeletal muscle cells.
Induced pluripotent stem cells differentiated into football players.
What is the main problem that Imane is trying to solve?
Understanding whether the Plectin mutation and resulting deficiency are responsible for causing muscular hypertrophy in elite bodybuilders.
Understanding whether the Plectin mutation and resulting deficiency are responsible for causing myocardial infarctionin undiagnosed patients.
Understanding whether the Plectin mutation and resulting deficiency are responsible for causing muscular dystrophy in undiagnosed patients.
Understanding whether the Plectin mutation and resulting deficiency are responsible for causing muscular dystrophy in diagnosed patients.
Why do you think spatial context is important for identifying functional domains in your own research?
Spatial context isn't really relevant
It connects gene expression profiles to their position in the tissue, which helps reveal organized structures.
Gene expression doesn't vary much across tissues.
We typically ignore spatial information since it's too noisy to be useful.
Could jsPCA be extended to integrate other spatial data modalities?
No, jsPCA is strictly limited to 2D spatial gene expression and cannot be modified.
It can’t be used with any modality that involves imaging data.
Yes, jsPCA can capture relevant spatial structures in a variety of contexts.
Any extension would require rewriting the entire algorithm from scratch.
Why is Gamora
How does the computational efficiency of jsPCA scale with increasing dataset size?
jsPCA slows down exponentially and crashes on anything over 100O cells.
jsPCA requires GPU clusters.
The algorithm becomes less accurate as the dataset grows.
Based on a sparse optimization approach.
What is the process in early embryonic development that leads to the formation of the three germ layers?
Neurulation
Fecundation
Gastrulation
Gastolation
From which germ layer most of the heart originate?
Endoderm
Mesoderm
Neuroctoderm
Ectoderm
Which novel model helps us bridge the gap between mouse models and human heart development in the Lescroart lab?
Mojito
Organiods
Cake
Gastruloids
More Mojito
