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WorksheetsTBL Nerv System iRAT
Total questions: 6
Worksheet time: 11mins
A 19-year-old man is diagnosed with acute psychosis secondary to schizophrenia and admitted him to the
psychiatric unit of the hospital. He is immediately administered with depot im haloperidol. On the 4th day, patient is found with tremors, muscular rigidity, and slowness of movements. He is suspected with Drug-induced Parkinsonism.
Which of the following actions of the drug on tracts of CNS?
Mesocortical
Mesolimbic
Tuberoinfundibular
Nigrostriatal
A 30-year-old man is brought to the clinic with a history of depression for the past 5 years with suicidal ideation and severe sleep disorders for the past 1 week. He is undergoing treatment with SSRI and MAOI, but the family members complain that his condition is becoming worse for the past 1 month. He is suspected with resistant depression and prescribed with imipramine. Which of the following mechanisms is most likely action of the above drug?
Blocks prejunctional α2
-adrenoceptors
Blocks prejunctional neuronal norepinephrine and serotonin
uptake transporters.
Inhibits monoamine oxidase
Modulation of GABA effects.
A 66-year-old man presents to the clinic for evaluation of a tremor. He has
noticed a progressively worsening tremor in his hands for the past 6 months.
The tremor is worse when he is resting and improves a little when he reaches
for an object or is using his hands. He has also noticed that it is harder to “get
started” when he stands up to walk. He takes several small, “shuffling” steps
before he can reach his full stride. He has no significant medical history and
takes only an aspirin a day. On examination you note that his face is fairly
expressionless, he has a pill-rolling-type tremor of his hands at rest and has
cogwheel rigidity of his arms. You diagnose him with Parkinson disease and
is prescribed with levodopa. Which of the following drugs is most likely prescribed with above drug?
Entacapone
Carbidopa
Benztropine
Trihexyphenidyl
A 69-year-old man presents to the Emergency Department with seizures for the past 20 minutes. He is given iv injection of lorazepam.
Which of the following mechanisms is most likely the actions of the above drug?
Inhibits Na+ channel blocking
Inhibits GABA transaminase of CNS.
Suppresses T-type Ca2+ current
Increase GABA inhibitory effects.
A 55-year-old man is brought to the Emergency Department after a motor vehicle accident. He had extensive crush and trauma related injuries on his left leg. He has an open fracture on his femur and tibia. He is immediately given morphine iv to control his pain.
Which of the following mechanisms best explains the actions of the above drug?
Activation of neuronal adenylyl cyclase
Increased prejunctional neurotransmitter release
Reduction of postjunctional neuronal potassium conductance
Reduction of prejunctional neuronal calcium conductance
Which of the following classes of drug is used as a muscle relaxant, antiepileptic, anxiolytic, antidepressants, sedative, hypnotic, preanaesthetic and centrally acting analgesic (all-in-one drug)?
SSRI
Barbiturates
Benzodiazepines
Phenytoin
