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WorksheetsXenobiotics and Metabolism Quiz
Total questions: 20
Worksheet time: 10mins
Which of the following best defines xenobiotics?
Essential nutrients
Foreign compounds in the body
Vitamins
Endogenous metabolites
Which organ is primarily responsible for xenobiotic metabolism?
Kidney
Liver
Lung
Skin
Which enzyme system plays a major role in Phase I reactions?
Alcohol dehydrogenase
Cytochrome P450
Glutathione peroxidase
Superoxide dismutase
Phase I reactions in xenobiotic metabolism include?
Conjugation
Hydrolysis
Acetylation
Glucuronidation
Which of the following is a Phase II reaction?
Oxidation
Hydroxylation
Glucuronidation
Reduction
What is the main purpose of Phase II reactions?
Detoxify by oxidation
Make xenobiotics more lipid soluble
Make xenobiotics more water soluble
Activate prodrugs
Which cofactor is required for glucuronidation?
PAPS
UDP-glucuronic acid
Acetyl-CoA
NADPH
Cytochrome P450 enzymes are located in?
Cytosol
Nucleus
Mitochondria
Smooth endoplasmic reticulum
Cytochrome P450 catalyzes what type of reactions?
Deamination
Hydroxylation
Acetylation
Decarboxylation
Methanol poisoning is treated by administering?
Formic acid
Ethanol
Isopropanol
Acetic acid
Why is ethanol effective in methanol poisoning?
It inhibits formic acid formation
It enhances methanol excretion
It activates cytochrome P450
It dilutes methanol
What toxic metabolite is responsible for methanol toxicity?
Ethanol
Acetaldehyde
Formic acid
Formaldehyde
Which unit is used for osmolarity?
mosmol/kg
mosmol/L
mol/L
mmol/L
Osmolality differs from osmolarity in that it is measured in?
Liters
Kilograms
Milliliters
Cubic meters
Normal plasma osmolality is approximately?
190–200 mosmol/kg
230–250 mosmol/kg
275–295 mosmol/kg
310–330 mosmol/kg
What is the normal plasma sodium level?
125–135 mEq/L
135–145 mEq/L
145–155 mEq/L
120–130 mEq/L
Normal potassium levels in plasma range from?
2–3 mEq/L
3.5–5.5 mEq/L
5.5–6.5 mEq/L
6.5–7.5 mEq/L
Normal total calcium level in plasma is?
4–6 mg/dL
6–8 mg/dL
8.5–10.5 mg/dL
10.5–12.5 mg/dL
Normal plasma chloride level is?
90–100 mEq/L
95–105 mEq/L
105–115 mEq/L
115–125 mEq/L
What is the normal plasma creatinine level?
0.1–0.3 mg/dL
0.6–1.3 mg/dL
1.5–2.5 mg/dL
2.5–3.5 mg/dL
