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Chem-Computational Toxicity Tools Quiz

Total questions: 25

Worksheet time: 13mins

Name
Class
Date
1.

What does the BOILED-Egg model predict?

a)

Solubility

b)

Toxicity

c)

GI absorption and BBB permeation

d)

Metabolism

2.

Which input format is most commonly used in toxicity prediction tools?

a)

CAS Number

b)

IUPAC Name

c)

SMILES

d)

InChI

3.

Which tool gives toxicity classification based on LD50 values?

a)

SwissADME

b)

PROTOX II

c)

Pred-hERG

d)

CarcinoPred-EL

4.

Which of the following tools predicts carcinogenicity using ensemble models?

a)

SwissADME

b)

CarcinoPred-EL

c)

LAZAR

d)

PreADMET

5.

SwissADME predicts the following EXCEPT:

a)

Water solubility

b)

GI absorption

c)

Mutagenicity

d)

Lipophilicity

6.

PROTOX II predicts which of the following?

a)

Protein-ligand docking

b)

hERG inhibition

c)

LD50 and toxicity class

d)

Carcinogenicity only

7.

Which of the following is not needed in SwissADME analysis?

a)

SMILES

b)

InChI

c)

PubChem ID

d)

Drug Name

8.

What is the full form of QSAR?

a)

Quantitative Structural Analysis Regression

b)

Quantitative Structure-Activity Relationship

c)

Quantum Structure Atomic Ratio

d)

Quality Statistical Active Regression

9.

Which is the correct SwissADME output for bioavailability?

a)

Toxicity class

b)

Bioavailability Radar

c)

Protein binding

d)

QT interval

10.

What is LD50?

a)

Dose lethal to 50% of the population

b)

Half the safe dosage

c)

Lowest effective dose

d)

Absorption rate

11.

What is the predicted unit for LD50 in PROTOX II?

a)

mg/L

b)

mg/kg

c)

µg/kg

d)

ppm

12.

Which organ-specific toxicity is predicted by PROTOX II?

a)

Skin

b)

Eyes

c)

Liver

d)

Lungs

13.

BOILED-Egg model represents absorption and permeability using:

a)

3D structure

b)

Radar plots

c)

2D scatter diagram

d)

Text output

14.

CarcinoPred-EL provides prediction from which model?

a)

XGBoost

b)

Random Forest

c)

SVM

d)

All of the above

15.

Which is NOT an input for CarcinoPred-EL?

a)

Molecular weight

b)

SMILES

c)

Drug name

d)

Chemical descriptor

16.

Which of the following is TRUE about SwissADME?

a)

Predicts hepatotoxicity

b)

Requires InChI only

c)

Predicts lipophilicity

d)

Needs logP file

17.

What color in BOILED-Egg indicates BBB permeation?

a)

Red

b)

Blue

c)

Yellow

d)

Green

18.

The PROTOX II web tool is hosted by:

a)

EMBL

b)

Charité Berlin

c)

NCBI

d)

Swiss Institute of Bioinformatics

19.

Which descriptor is used for prediction in SwissADME?

a)

Lipinski rules

b)

QSAR weight

c)

Toxicity index

d)

Risk class

20.

In SwissADME, GI absorption is shown as:

a)

High or Low

b)

Numerical range

c)

Color codes

d)

Graph

21.

CarcinoPred-EL classifies compounds as:

a)

Safe or unsafe

b)

Carcinogen or non-carcinogen

c)

Risk group I-IV

d)

Bioactive or inactive

22.

Which compound is typically used for GI tract prediction testing?

a)

Ibuprofen

b)

Ethanol

c)

Sulfur dioxide

d)

Sodium chloride

23.

PubChem provides all the following EXCEPT:

a)

SMILES

b)

CID

c)

LD50 value

d)

Molecular formula

24.

What can you infer from a low LD50 value?

a)

Less effective

b)

More toxic

c)

Poor solubility

d)

Higher absorption

25.

Which of the following is free to access for toxicity analysis?

a)

SwissADME

b)

ChemOffice

c)

PyMOL

d)

MATLAB