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5. Alkylating Agents (Mo):

Total questions: 31

Worksheet time: 20mins

Name
Class
Date
1.

Which of the following is a warning sign of Cancer? SATA

a)

Sore that does not heal

b)

Lump and dimpling in the breast

c)

A mole that changes size and color

d)

A change in bowel and bladder habits

e)

A persistent cough that is associated with difficulty in swallowing

2.

Which of the following is included in the M2 Regimen that is used to treat Multiple Myeloma? SATA

a)

Cytoxan

b)

Methotrexate

c)

CCNU

d)

Prednisone

e)

Vincristine

3.

Which of the following in the metabolic pathway of Cytoxan is responsible for its Cytotoxic effect?

a)

4-hydroxy-cyclophosphamide

b)

4-keto-cyclophosphamide

c)

Acrolein

d)

Phosphoramide Mustard

e)

Carboxy-phosphamide

4.

Which of the following metabolic pathway of Cytoxan is responsible for its adverse effect of therapy limited toxicity?

a)

4hydroxy-cyclophosphamide

b)

4keto-cyclophosphamide

c)

Acrolein

d)

Phosphoramide Mustard

e)

Carboxy-phosphamide

5.

Which of the following is a Non-Cancer Indication of Cyclophosphamide (Cytoxan)? SATA

a)

Diabetes Insipidus

b)

Rheumatoid Arthritis

c)

Prevention of Organ Rejection

d)

Autoimmune Disease

e)

SIADH

6.

Which of the following is LEAST LIKELY to be a non-cancer indication of Cyclophosphamide?

a)

Rheumatoid Arthritis

b)

Prevention of Organ Rejection

c)

SIADH

d)

Inflammation

e)

Diabetes Insipidus

7.

Which of the following is BEST classified as a Nitrogen Mustard? SATA

a)

Yondelis

b)

Busulfan

c)

Chlorambucil

d)

Hexamethylamelammine

e)

Streptozocin

8.

Which of the following is BEST classified as a Nitrogen Urea? SATA

a)

Yondelis

b)

Busulfan

c)

Chlorambucil

d)

Hexamethylmelammine

e)

Streptozocin

9.

Which of the following is BEST classified as a Nitrogen Mustard? SATA

a)

Leukeran

b)

Alkeran

c)

Trabectedin

d)

Cytoxan

e)

Yondelis

10.

Which of the following is BEST classified as a Nitrogen Urea? SATA

a)

Carmustine

b)

Zanosar

c)

CCNU

d)

Streptozocin

e)

ThioTEPA

11.

Which of the following would be considered Alkylatins? SATA

a)

Cyclophosphamide

b)

Dacarbazine

c)

Chlorambucil

d)

Myleran

e)

Kerydin

12.

What are the beneficial effects of Pomalidomide in Multiple Myeloma? SATA

a)

Increase Capase Activity

b)

Increase in apoptosis of myeloma cells

c)

Increase of production of IL-6

d)

Decrease in the proliferation of Myeloma Cells

e)

Decrease in angiogenesis

13.

Which of the following would be observed during therapy with Lenalidomide? SATA

a)

Increase capase activity

b)

Increase apoptosis of myeloma cells

c)

Increase of production of IL-6

d)

Decrease in the proliferation of myeloma cells

e)

Decrease in angiogenesis

14.

Which of the following would be observed during therapy with Thalidomide?

a)

Increase capase activity

b)

Increase in apoptosis of myeloma cells

c)

Increase of production of IL-6

d)

Decrease in the proliferation of myeloma cells

e)

Decrease in angiogenesis

15.

Thalidomide is effective in the management of Multiple Myeloma because Thalidomide: SATA

a)

Inhibits Caspase 8

b)

Inhibits IL-6 Production

c)

Inhibits angiogenesis

d)

Stimulates Poly-ADP Ribose Polymerase-1

e)

Stimulates Cyclin-Dependent Kinase-4

16.

Which of the following is NOT involved in the T2 Regimen?

a)

Doxyrubicin and D-ACT

b)

Doxyrubicin, Oncovin, and Cyclophosphamide

c)

Ifosphamide, Mesna, and Itoposide

d)

Oncovin and Cyclophosphamide

e)

Cytoxan

17.

Which of the following is a cell cycle non-specific anticancer drug?

a)

Gemcitabine

b)

Cyclophosphamide

c)

Methotrexate

d)

Capecitabine

e)

Etoposide

18.

Which of the following is an indication of Yondelis? SATA

a)

Liposarcoma

b)

Ovarian Cancer

c)

Pancreatic Cancer

d)

Gastric Cancer

e)

Leiomyosarcoma

19.

Triethylenethiophosphoramide is used to treat which of the following? SATA

a)

Pancreatic Cancer

b)

Ovarian Cancer

c)

Head and Neck Cancer

d)

Breast Cancer

e)

Bladder Cancer

20.

Which of the following is LEAST LIKELY to be an adverse effect of Cytoxan?

a)

Sterility

b)

Diabetes Insipidus

c)

Hemorrhagic Cystitis

d)

Cancer

e)

SIADH

21.

Which of the following is BEST classified as a Nitrosourea Alkylating Agent?

a)

Ifosfamide

b)

Melphalan

c)

Busulfan

d)

DTIC

e)

Streptozotocin

22.

Which of the following is LEAST LIKELY to be combined with Dexamethasone for the treatment of Multiple Myeloma?

a)

Carfilzomib

b)

Daratumumab

c)

Ribociclib

d)

Lenalidomide

e)

Elotuzumab

23.

Which of the following agents that are used to treat Multiple Myeloma is an inhibitor of Histone Deacetylase?

a)

Pomalidomide

b)

Melphalan

c)

Teclistamab

d)

Panobinostat

e)

Doxorubicin

24.

Which of the following is a cell cycle non-specific anticancer drug?

a)

Gemcitabine

b)

Cyclophosphamide

c)

Methotrexate

d)

Capecitabine

e)

Etoposide

25.

Thalidomide is effective in the management of Multiple Myeloma because Thalidomide: SATA

a)

Inhibits Cascade 8

b)

Inhibits IL-6 production

c)

Inhibits Angiogenesis

d)

Stimulates Poly-ADP Ribose Polymerase-1

e)

Stimulates Cyclin-Dependent Kinase-4

26.

Mr. Ju’s Non-Hodgkin’s Lymphoma is being treated with the DHAP regimen. Considering the contents of that regimen, which of the following is Mr. Ju receiving? SATA

a)

Hexamethylmelamine

b)

ara-C

c)

Cisplatin

d)

Adriamycin

e)

Dexamethasone

27.

Which of the following is LEAST LIKELY to be a component of the mBACOS regimen that is used to treat Non-Hodgkin’s Lymphoma?

a)

Doxorubicin

b)

Dexamethasone

c)

Bleomycin

d)

Vincristine

e)

Cytoxan

28.

Which of the following is LEAST LIKELY to be a non-cancer indication of Cyclophosphamide?

a)

Rheumatoid Arthritis

b)

Prevention of Organ Rejection

c)

SIADH

d)

Inflammation

e)

Diabetes Insipidus

29.

Triethylenethiophosphoramide is used to treat which of the following? SATA

a)

Pancreatic Cancer

b)

Ovarian Cancer

c)

Head and Neck Cancer

d)

Breast Cancer

e)

Bladder Cancer

30.

Which of the following is LEAST LIKELY to be an adverse effect of Cytoxan?

a)

Sterility

b)

Diabetes Insipidus

c)

Hemorrhagic Cystitis

d)

Cancer

e)

SIADH

31.

Which of the following is BEST classified as a Nitrosurea Alkylating Agent?

a)

Ifosfamide

b)

Melphalan

c)

Busulfan

d)

DTIC

e)

Streptozotocin

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