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WorksheetsTumor Immunology
Total questions: 5
Worksheet time: 4mins
Which of the following best describes a Tumor-Specific Antigen (TSA)?
An antigen expressed by both tumor and normal cells
A self-antigen overexpressed in cancer cells
An antigen arising from mutations unique to tumor cells
An antigen found only on embryonic tissues
A surface protein involved in angiogenesis
A key mechanism by which Natural Killer (NK) cells recognize and eliminate tumor cells is by detecting:
High expression of MHC class I molecules
Presence of neoantigens on tumor cells
Antigen presentation via dendritic cells
Loss or downregulation of MHC class I molecules
CD28 co-stimulation on T cells
Which of the following is considered a primary role of CD8+ cytotoxic T lymphocytes (CTLs) in anti-tumor immunity?
Promoting B cell differentiation
Direct killing of tumor cells via perforin and granzyme
Enhancing regulatory T cell function
Presenting antigen to naïve T cells
Inducing angiogenesis
Tumors have developed numerous strategies to evade immune surveillance. All of the following are recognized mechanisms of immune evasion EXCEPT:
Upregulation of MHC class I molecules
Downregulation of tumor antigens
Secretion of immunosuppressive cytokines, TGF-β
Recruitment of regulatory T cells (Tregs)
Expression of immune checkpoint molecules, PD-L1
Chimeric Antigen Receptor (CAR) T-cell therapy involves genetically modifying a patient's T cells. What component of the CAR construct is responsible for recognizing the antigen on the tumor cell?
CD3ζ signaling domain
Costimulatory domain (e.g., CD28 or 4-1BB)
Hinge region
Single-chain variable fragment
Transmembrane domain
