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Toxicology HY 2

Total questions: 20

Worksheet time: 12mins

Name
Class
Date
1.

A 17-year-old boy who is having a seizure is brought to the emergency department by his mother who reports that he took too many of his Tofranil. What initial step should be taken to manage this patient?

a)

Administer diazepam

b)

administer phenytoin

c)

check glucose level

d)

check drug level

2.

A child is brought by ambulance to the emergency department from an accidental overdose. The mother who accompanies the child is unsure of what blood pressure pills the child ingested. Which of the following might help to differentiate beta-blocker toxicity rather than calcium channel blocker toxicity?

a)

Bradycardia

b)

Hyperglycemia

c)

Hypoglycemia

d)

Hypotension

3.

Why are nondihydropyridine calcium channel blockers not recommended or preferred in acute decompensated heart failure?

a)

Decreased cardiac output

b)

Increased depolarization

c)

Protection against sudden cardiac death

d)

Reduce remodeling of the myocardium

4.

During lead chelation therapy, the primary site of action for edetate calcium disodium (CaNa2EDTA) is bone. In order to prevent redistribution of lead into the CNS, which of the following agents should be used in combination with edetate calcium disodium?

a)

N-acetylcysteine

b)

Dimercaprol

c)

Prussian blue

d)

Deferoxamine

5.

A patient with tricyclic antidepressant (TCA) toxicity has started to develop hypotension despite fluid resuscitation and a sodium bicarbonate infusion. The patient has not had any ventricular dysrhythmias. What is the most appropriate treatment?

a)

Urinary alkalinization

b)

Norepinephrine

c)

Extracorporeal membrane oxygenation (ECMO)

d)

Hemodialysis

6.

You are counseling a patient who is concerned about the ingestion of organic mercury compounds, particularly methylmercury, a potential contaminant in seafood. Which of the following symptoms would be concerning for methylmercury toxicity? (Select all that apply)

a)

Acute GI distress

b)

Tremor

c)

Ataxia

d)

Fatigue

7.

A 65-year-old female called in to request advice on first aid following a snakebite as she is planning a hiking vacation in the Grand Canyon. Which of the following is recommended in the first aid management of North American Pit Viper envenomation?

a)

Use a commercially available snake venom suction kit

b)

Apply a tourniquet to the extremity where envenomation occurred

c)

Slow the spread by calming the victim to help lower the heart rate

d)

Hunt down the snake for positive identification in the ED

8.

Which of the following can be used for the chelation of copper if there is a concern for toxicity?

a)

D-penicillamine

b)

DMPS

c)

N-acetylcysteine

d)

Succimer

9.

A patient with Rheumatoid arthritis develops signs and symptoms concerning for methotrexate toxicity. What treatment can be used? (Select ALL that apply)

a)

Voraxaze

b)

Leucovorin

c)

Edrophonium

d)

Fomepizole

10.

A 34-year-old male is presenting to the ED following snakebite to his right hand approximately 15 minutes ago. He discloses it was his pet monocellate cobra (Naja kaouthia), which he imported to the USA. He is diaphoretic, experiencing weakness, paresthesias, and numbness in the right and with swelling extending proximal to the right wrist. In regards to the use of antivenom, which of the following would be the most appropriate response at this time? (Select all that apply)

a)

Search Antivenom Index via Poison Control Center consultation

b)

Administer CroFab

c)

Search Miami-Dade Fire Rescue Venom Response Program via Poison Control Center consultation

d)

Administer Anavip

11.

A 34-year-old male is presenting to the ED following snakebite to his right hand approximately 15 minutes ago. He discloses it was his pet monocellate cobra (Naja kaouthia), which he imported to the USA. He is diaphoretic, experiencing weakness, paresthesias, and numbness in the right and with swelling extending proximal to the right wrist. In regards to the use of antivenom, which of the following would be the most appropriate response at this time? (Select all that apply)

a)

Administer Anavip

b)

Search Miami-Dade Fire Rescue Venom Response Program via Poison Control Center consultation

c)

Search Antivenom Index via Poison Control Center consultation

d)

Administer CroFab

12.

A 23-year-old male presents to the ED following a snakebite while he was hiking outside of Phoenix, Arizona, when he was bitten on the right hand after clearing debris from the trail. He did not see the snake, but there are two puncture marks on his hand and pain and swelling extending proximal to the wrist. The team in the ED discussed using Anavip (Crotalidae equine immune F(ab')2) and reviewing the patient's medical record; he has no past medical history but reports an allergy to penicillin (rash), and papaya (anaphylaxis). Which of the following is the most appropriate recommendation at this time?

a)

Anavip 10 vials IV now

b)

Change to CroFab 6 vials IV now followed by 2 vials q6h for three doses

c)

No antivenom since we can't confirm what type of snake bit him

d)

Antivenom only indicated after failing fasciotomy

13.

You have a patient who received a complete course of Crofab for a snakebite earlier that day. Unfortunately, the erythema, edema, and pain of the extremity where the envenomation occurred by the snake bite were present at the time of CroFab initiation has not resolved but is also no longer progressing. Which of the following is the most appropriate recommendation at this time?

a)

CroFab failure, administer Anavip

b)

Continue CroFab 2 vials IV q6h until erythema, edema, and pain resolves

c)

CroFab appropriately prevented progression of envenomation

d)

Consult surgery for decompressive fasciotomy

14.

A patient is brought to the emergency department after a reported amitriptyline overdose with desipramine. Which of the following EKG changes is commonly seen due to this type of toxicity? (Select ALL that apply)

a)

Bundle branch blocks

b)

Deep S-waves in lead 1

c)

Scooped ST segments

d)

Wide QRS interval

15.

Which of the following most accurately describes the mechanism of action for sodium bicarbonate in beta-blocker toxicity?

a)

Bypass normal catecholamine generated influences on cAMP and increase cAMP via other mechanisms which has been shown to increase pulse and blood pressure

b)

Increase of cytosolic calcium concentrations thus improving inotropy

c)

Increase sodium uptake through nodal cell

d)

Promotes glucose uptake and carbohydrate metabolism to generate energy during myocardial stress

16.

A 44-year-old female presents to the emergency department (ED) following an intentional overdose of an unknown drug and unknown quantity. Per EMS, she was bradycardic (HR 22 bpm) and hypotensive (80/-- mmHg) with a GCS of 6 on initial evaluation, prompting emergent rapid sequence intubation (RSI; using etomidate and succinylcholine) with a supraglottic airway and IV sodium chloride 0.9% 1 L bolus. Upon ED presentation, the patient has a GCS of 3T with unchanged vital signs (HR 25 bpm, BP 80/33 mmHg, Temp 99F, O2 99%) and a finger stick glucose of 240 mg/dL. Which of the following is the most likely medication that was ingested

a)

Aspirin

b)

Amlodipine

c)

Bisoprolol

d)

Amitriptyline

17.

What phase of the cardiac action potential within the ventricular myocardium is mainly affected by tricyclic antidepressants (TCAs) and creates most of the problems in patients who overdose on them?

a)

Phase 4

b)

Phase 0

c)

Phase 1

d)

Phase 2

18.

A 44-year-old female presents to the emergency department with complaints of shortness of breath. On physical exam, pertinent positive findings include tachypnea and hyperpnea with a temperature of 101 F. All other findings are within normal limits. Her home medication list includes aspirin 325 mg by mouth daily, Fiorinal 2 tablets every 8 hours as needed for headache, and BC Powder 1 packet every 6 hours as needed for headache. Which of the following is the most likely diagnosis?

a)

Butalbital toxicity

b)

Opioid toxicity

c)

Salicylate toxicity

d)

Acetaminophen toxicity

19.

A 3-year-old male accidentally ingested antifreeze when left unsupervised in his parent's garage. The ingestion occurred approximately 30 minutes before the presentation. What is the most appropriate action at this time?

a)

Activated charcoal 1g/kg by mouth

b)

activated charcoal with sorbitol 1g/kg by mouth

c)

urinalysis with woods lamp examination

d)

Call 1-800-222-1222

20.

A patient with a suspected pulmonary embolism was started on unfractionated heparin in the emergency department. The patient develops an intraocular hemorrhage. What treatment would you recommend?

a)

digibind

b)

Idarucizumab

c)

Protamine sulfate

d)

Vitamin K