WorksheetsBIOCHEMISTRY OF THE NERVOUS SYSTEM
Total questions: 20
Worksheet time: 11mins
What percentage of the body's total energy expenditure does the brain account for, despite being only 2% of body weight?
5–10%
10–15%
20–25%
30–35%
Which components are part of the neuronal membrane?
Phospholipid (e.g., lecithin, cephalin)
Cholesterol
Ganglioside
Glycogen
Which component is more abundant in gray matter compared to white matter?
Water
Protein
Lipid
Carbohydrate
The gray matter has a higher lipid content than the white matter due to the myelinated axons.
True
False
Myelin sheaths allow for saltatory conduction, increasing the speed of transmission and energy efficiency.
True
False
What is the primary energy source for the brain, consumed at about 103 g per day?
Fatty acids
Protein
Glucose
Ketone
Which cofactor is necessary for the synthesis of GABA from glutamate via glutamate decarboxylase?
Acetyl-CoA
Pyridoxal phosphate
NADH
FADH₂
Which neurotransmitter is broken down by acetylcholinesterase after being released?
Dopamine
Glutamate
GABA
Acetylcholine
Which enzyme is involved in the breakdown of catecholamines such as dopamine and norepinephrine?
Acetylcholinesterase
Glutamate decarboxylase
Monoamine oxidase (MAO)
Choline acetyltransferase
What are the characteristics of neuropeptides?
Synthesized in the soma of neurons
Influence pain perception and mood
Synthesized at the presynaptic terminals
Act rapidly for movement and cognition
Which pathways are involved in glucose metabolism in the nervous system?
Glycolysis
Tricarboxylic Acid (TCA) Cycle
Astrocyte-Neuron Lactate Shuttle
Beta-oxidation of fatty acids
Which neurotransmitters are inhibitory in terms of functional classification?
GABA
Glycine
Taurine
Glutamate
What are some examples of neuropeptides and related details?
β-endorphin, extracted from β-lipotropin
Enkephalins, affecting pain perception
Somatostatin, produced in the soma of neurons
Dopamine, synthesized in the presynaptic terminals
GABA is synthesized from glutamate through glutamate decarboxylase and acts as an excitatory neurotransmitter.
True
False
The brain is highly sensitive to hypoxia, with irreversible damage possible after 5–6 minutes.
True
False
Cocaine addiction is related to catecholamine disorders by enhancing their reuptake into the presynaptic terminals.
True
False
In Tay-Sachs disease, defective (a) metabolism leads to toxic accumulation in neurons.
The pentose phosphate pathway produces (a) , an important antioxidant cofactor in the brain.
In the brain, (a) such as cerebrosides and gangliosides are concentrated in myelin (90% of cerebrosides) and support insulation and signaling.
Disruption in energy metabolism, such as (a) , reduces ATP production and can lead to seizures or coma.
