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Cardiology HY #1

Total questions: 20

Worksheet time: 10mins

Name
Class
Date
1.

Which of the following statements is TRUE regarding the use of warfarin to prevent cardioembolic stroke in a patient with atrial fibrillation?

a)

Warfarin therapy is recommended for 3 weeks prior to cardioversion to normal sinus rhythm

b)

Warfarin therapy is recommended for 2 weeks after cardioversion to normal sinus rhythm

c)

The risk of intracranial hemorrhage with warfarin increases once the INR is greater than 2

d)

Warfarin initiation prior to cardioversion is necessary once the patient has been in atrial fibrillation for 24 hours

2.

Which of the following statements about metformin use in patients with heart failure (HF) is TRUE?

a)

Only patients with Stage C or D HF should avoid taking metformin

b)

Patients with any structural heart disease (Stage B or worse) should avoid taking metformin

c)

All patients with HF should avoid taking metformin

d)

Despite previous warnings, it is safe for most patients with HF to take metformin

3.

You are managing a black-American male with heart failure in your clinic. He is currently taking an optimal regimen of lisinopril, carvedilol, and furosemide. However, he continues to experience moderate to severe heart failure symptoms despite this therapy. Which of the following add-on therapies has been shown to improve outcomes specifically in the black or African American population?

a)

Digoxin

b)

isosorbide dinitrate / hydralazine

c)

Losartan

d)

spironolactone

4.

Which of the following ECG abnormalities is most likely to occur in with the use of amiodarone or sotalol, especially in patients with hypokalemia?

a)

PR interval shortening

b)

T-wave inversion

c)

QRS narrowing

d)

QT prolongation

5.

A 58-year-old Hispanic male has a past medical history of coronary artery disease s/p MI x 3, hypertension, heart failure (LVEF 35%), dyslipidemia, and type 2 diabetes mellitus. He was recently seen by his family doctor for continued uncontrolled hypertension, and a "new medication was added." Today, he comes to the clinic complaining of increased shortness of breath and fatigue and symptoms consistent with paroxysmal nocturnal dyspnea and orthopnea. Current medications: fosinopril 40 mg daily glipizide 5 mg twice a day furosemide 40 mg twice a day metoprolol succinate 12.5 mg daily pravastatin 20 mg at night verapamil extended-release 240 mg daily The patient can't remember which of the above medications was added by his family doctor. Which of the following medication is MOST LIKELY causing this patient's acute condition?

a)

fosinopril

b)

furosemide

c)

metoprolol succinate

d)

verapamil

6.

Which of the following best describes the safety and efficacy with the use of ezetimibe without statin therapy in HIV-infected patients being treated with highly active antiretroviral therapy (HAART) and also have dyslipidemia?

a)

Less lipid lowering than in HIV-negative patients but with equal safety

b)

Comparable lipid lowering efficacy but with a greater risk for myopathy

c)

Greater lipid lowering than in HIV-negative patients but with no differences safety

d)

Comparable safety and ecacy to use in HIV-negative patients

7.

Which of the following antiarrhythmic agents would be the best option to maintain normal sinus rhythm in a patient with atrial fibrillation and who has hypertension with substantial left ventricular hypertrophy related heart failure?

a)

dofetilide

b)

amiodarone

c)

propafenone

d)

dronedarone

8.

A 62-year-old White female reports to the clinic for a routine follow-up. She has a past medical history of type 2 diabetes mellitus, dyslipidemia, and hypothyroidism. She has no complaints to report today and states compliance with her medication regimen. Current medications: Glipizide 10 mg twice a day Metformin 1000 mg twice a day Insulin detemir 15 units in the morning Levothyroxine 100 mcg daily Atorvastatin 20 mg at bedtime Fasting Labs (selected) from today: GLU = 182, SCr = 1.1, AST = 18, ALT = 24, A1c = 8.8% TChol = 183, HDL = 48, LDL (unable to calculate), TG = 468, direct LDL = 48, TSH = 2.3 Based on the above information, which of the following recommendations would be the most appropriate?

a)

increase atorvastatin to 40mg at bedtime

b)

intensify diabetes therapy

c)

add cholestyramine 4 gm twice a day

d)

increase levothyroxine to 125 mcg daily

9.

You are seeing an adult patient who is taking aspirin for his arthritis. Which of the following best describes the primary mechanism of action of aspirin?

a)

a competitive inhibitor of thrombin

b)

a competitive inhibitor of ADP receptor

c)

an irreversible inhibitor of cyclooxygenase-1 (COX-1)

d)

An irreversible inhibitor of the P2Y12 receptor

10.

A provider asks for your thoughts about starting Lovaza in a patient. What warning should be considered before making a recommendation?

a)

sulfa allergy

b)

increased risk of bleeding

c)

Vitamin B12 deficiency

d)

Depression

11.

A 45-year-old patient reported to the clinic today with the following blood pressure history: 154/96 (previous visit) and 149/96 (current visit). Based on these readings, which of the following statements is most appropriate?

a)

Patient's blood pressure is within normal limits

b)

Patient has prehypertension

c)

Patient has hypertension

d)

Patient has Stage 1 hypertension

12.

A patient with dyslipidemia needs to administer their evolocumab. Which instruction regarding how to administer evolocumab is correct?

a)

Shake well to suspend the injection solution

b)

administer intravenously over 20 minutes

c)

inject a once-monthly dose over 5 minutes with an on-body infusor

d)

administer in 2 separate injections at 2 injection sites

13.

Which of the following best describe the mechanism of action for Zaroxolyn?

a)

Inhibits sodium and water reabsorption in the proximal convoluted tubule of the nephron

b)

Inhibits sodium and water reabsorption by blocking the effects of aldosterone in the distal convoluted tubule

c)

Inhibits the activity of antidiuretic hormone (ADH) at the V2 receptor in the collecting duct

d)

Inhibits sodium and water reabsorption in the distal convoluted tubule by inhibiting the Na/Cl co-transporter

14.

A 50-year-old African American male with a past medical history of hyperlipidemia, hypertension, type 2 diabetes, myocardial infarction (MI) status post stent placement (4 months prior), and depression presents to your clinic for hyperlipidemia management. He does not use any tobacco products and drinks approximately 20 beers in 1 week. He is currently on pravastatin 80 mg daily and tolerating it well. Fasting laboratory test results show total cholesterol 160 mg/dL, triglycerides 225 mg/dL, HDL 30 mg/dL, LDL 85 mg/dL, ALT 83 IU/L and AST 90 IU/L. What is the best management strategy for treating his hyperlipidemia based on the ACC/AHA lipid guidelines?

a)

Discontinue statin therapy due to elevated ALT and AST levels

b)

Discontinue pravastatin and start simvastatin 40 mg daily

c)

Discontinue pravastatin and start ezetimibe 10 mg daily

d)

Discontinue pravastatin and start rosuvastatin 20 mg daily

15.

Which correctly describes the role of the venous system in the compensatory response in patients with heart failure?

a)

Increased venous return improves cardiac output and corrects the underlying pathophysiology

b)

Venous constriction increases stroke volume, worsening symptoms of heart failure

c)

Decreased venous return improves cardiac output and corrects the underlying pathophysiology

d)

Venous dilation increases stroke volume, worsening symptoms of heart failure

16.

LZ is a 55-year-old African American male who has been in atrial fibrillation for the last ten days. LZ's past medical history includes STEMI s/p CABG three years ago and diabetes mellitus. This is LZ's first episode of atrial fibrillation. His echocardiogram from one month ago shows an ejection fraction of 50% and no left ventricular hypertrophy. LZ complains of occasional palpitations that occur mostly while he is active (e.g., doing yard work). His current heart rate is 120 bpm, and his blood pressure is 130/85 mmHg. Current medications include aspirin 81 mg daily and metoprolol tartrate 50 mg by mouth twice daily for coronary artery disease, lisinopril 10 mg by mouth once daily for his hypertension and glipizide 5 mg by mouth once daily for his diabetes. Which of the following antiarrhythmic agents is NOT recommended to maintain normal sinus rhythm in LZ?

a)

propafenone

b)

dofetilide

c)

amiodarone

d)

dronedarone

17.

Which of the following is an accurate statement about P2Y12 ADP receptor antagonists?

a)

Clopidogrel only undergoes phase II metabolism to get activated and is a reversible inhibitor of the P2Y12 ADP receptor

b)

Patients who have received Brilinta may not have to wait 5 days if open heart surgery is needed due to its reversible inhibition

c)

Ticlopidine only needs to be dosed once daily but requires monitoring of the CBC due to a risk of agranulocytosis

d)

Effient is metabolized by CYP3A4 to inactive metabolite and causes a reversible inhibition of the P2Y12 ADP receptor

18.

A 48-year-old male presents to the emergency department (ED) for new-onset shortness of breath. He was discharged from the hospital 4 days before for an acute STEMI that required primary coronary intervention. When discharged, he was started on new drug therapy, including aspirin, ticagrelor, metoprolol, and rosuvastatin. His current vital signs in the ED are HR 45 bpm, BP 110/80 mmHg, RR 44 bpm, O2 saturation 88% on room air, and temperature of 98.7 F. Which of the following are appropriate interventions at this time?

a)

change rosuvastatin to atorvastatin

b)

change metoprolol to verapamil

c)

change ticagrelor to prasugrel

d)

continue all post-MI drug tehrapy

19.

A patient with heart failure with reduced ejection fraction (HFrEF) presents to your medication management clinic and has a question about his lab notification letter. He noticed a test for B-type natriuretic peptide (BNP) was slightly elevated. Which of the following educational points is correct?

a)

Patients who are on sacubitril/valsartan therapy have elevated BNP levels

b)

BNP should not be used to assist with diagnosis or exclusion of heart failure (HF) as a cause of symptoms (dyspnea or weight gain)

c)

Elevated BNP is only due to cardiac causes

d)

BNP and N-terminal- pro hormone BNP (NT-proBNP) are exactly the same and can be used interchangeably

20.

What laboratory value can be signicantly aected by argatroban?

a)

White blood cell (WBC) count

b)

Serum creatinine (SCr)

c)

Aspartate aminotransferase (AST)

d)

International normalized ratio (INR)