WorksheetsSGM 1: Cell Cycle Disruptions and Disease
Total questions: 10
Worksheet time: 8mins
Which of the following best describes the normal function of the cell cycle in healthy cells?
To allow cells to divide uncontrollably
To regulate cell growth, division, and death in an orderly manner
To prevent cells from dividing at all
To cause mutations in DNA
What is the primary role of checkpoints during the cell cycle?
To speed up cell division
To ensure that damaged or incomplete DNA is not passed to daughter cells
To destroy healthy cells
To create new types of cells
Which phase of the cell cycle is most directly associated with DNA replication?
G1 phase
S phase
G2 phase
M phase
A student views a diagram of normal cells and cancer cells. The normal cells show uniform spacing, while the cancer cells are disorganized and overlapping. Which conclusion is most accurate?
A researcher observes a tumor that is benign. Which characteristic most likely applies?
The tumor cells have spread to other tissues.
The tumor is localized and does not invade surrounding tissue.
The tumor is resistant to treatment.
The tumor cells divide uncontrollably and metastasize.
A scientist observes a group of cells that continue to divide even after the tissue is fully formed. Which cell cycle disruption is most likely occurring?
The cells are stuck in the G0 phase
Failure of DNA repair and Checkpoint systems
Failure of DNA Replication
D. Failure of cytokinesis
If a model shows a cell bypassing the G2 checkpoint despite having DNA damage, what is the likely consequence for the organism?
The cell will function normally
The cell may divide with mutations, increasing the risk of cancer
The cell will immediately die
The cell will repair itself before dividing
A group of cells has a mutation that prevents apoptosis. Which outcome is most likely?
A. The cells will repair themselves and continue normal growth
B. The cells will stop dividing after one cycle
C. The abnormal cells will survive and possibly form a tumor
D. The immune system will immediately destroy all abnormal cells
A case study describes a patient with melanoma. Doctors explain that the cancer developed after years of UV exposure, which caused mutations in skin cell DNA. Which statement best explains this?
Environmental factors can damage DNA, leading to cancer.
UV light makes cells divide more slowly.
Skin cells stop dividing once they are mutated.
Cancer cannot be influenced by environmental conditions.
Explain how disruptions in the cell cycle, such as mutations or checkpoint failures, can lead to the development of cancer. In your answer, describe the normal role of checkpoints and how their failure changes cell behavior. Provide an example of what might happen to a cell when it cannot repair damaged DNA
