Which of the following numbers is appropriately documented?

Which of the following is not appropriate for the correction of a documentation error?

Which of the following is a feature of the classical pathway of the complement system?

Which of the following is the central component of all three pathways?

A 36-year-old woman comes to her physician for worsening fatigue and muscle aches for 1 month. She describes that mostly she is more fatigued by the end of the day and also occasionally has pain in her wrist and knee. She has not had any falls and takes no medications. She has lost 6.8 kg (15 lb) in the past year. She has not had fever. She is 162.5 cm (5 ft 4 in) tall and weighs 53.5 kg (118 lb); body mass index is 20.2 kg/m2. Temperature is 37°C (98.6°F), pulse is 100/min, respirations are 18/min, and blood pressure is 130/80 mm Hg. Physical examination shows red, painful joints in the wrists and knees but no joint deformations. The skin appears normal; there are no rashes. Her lungs are clear and the cardiac examination is normal. Laboratory studies show: 

Which of the following laboratory abnormalities is most likely in this patient?

What is the only positive regulator of the alternative pathway

RT is a 35-year-old male who presents to the emergency department with a 12-hour history of high fever (39.5°C), severe headache, neck stiffness, and a rapidly progressing rash. Gram stain of the cerebrospinal fluid shows gram-negative diplococci consistent with Neisseria meningitidis. He has also had Haemophilus influenzae type b and Streptococcus pneumoniae pneumonias in the past. Why is RT predisposed to infections with encapsulated bacteria?

Which organ is a major producer of complement proteins

Which of the following is the starting point for the membrane attack complex?

What is the consequence of inappropriate complement activation

Which of the following is NOT a cardinal sign of inflammation?

Blake is a 12yo soccer player who has started wheezing after running around outside with his siblings. Which leukocyte is most responsible for this child's illness?

Jack and Jill went up a hill to fetch a pail of water. Jack fell down and cut open his knee. Jill tumbled down the hill after Jack but came up uninjured. Unfortunately, Jack has a selectin deficiency. Which part of leukocyte recruitment would be impaired in Jack’s case?

A 3-year-old boy presents with recurrent episodes of pneumonia, lymphadenitis, and hepatic abscesses. His past medical history is notable for poor wound healing and a severe skin infection following a minor abrasion. Family history reveals a maternal uncle who died in childhood from a severe infection. Laboratory studies show normal lymphocyte and immunoglobulin levels. A dihydrorhodamine (DHR) flow cytometry test demonstrates markedly reduced neutrophil oxidative burst. Which of the following is most likely unable to be produced by this patient’s phagocytes as a result of his condition?

An 18 year old college student was playing ultimate frisbee with his friends when he got elbowed in the face by a player on the other team. After the game, he took some ibuprofen to help with the inflammation. What is the mechanism of action of the arachidonic acid metabolites that ibuprofen inhibits?

A 32-year-old man sustains a deep laceration to his forearm. Over the next several weeks, the wound heals but develops a firm, raised scar. Histological examination of the scar tissue reveals increased deposition of collagen types I and III, as well as abundant myofibroblasts expressing α-smooth muscle actin (α-SMA). Which of the following cytokines is most directly responsible for promoting the deposition of connective tissue in this scar?

A 32-year-old man presents with a painful, erythematous, fluctuant lesion on his forearm. He reports fever and malaise for the past 24 hours. Incision and drainage yield purulent material. A histological section of the lesion is shown. Which of the following best describes the predominant cellular process occurring in this lesion?

Which pair of cytokines are most responsible for inducing fever?

Which of the following cell types of the innate immune system does not perform phagocytosis?

Which of the following is not a component of innate immunity

A patient with a mutation in TLR4 would most likely have impaired recognition of which microbial component?

TLRs are an example of which of the following?

A 25-year-old man is bitten by a stray dog. Within hours, neutrophils are recruited to the wound site. Which of the following BEST describes the role of neutrophils in the innate immune response?

Which of the following cell types is not formed from the lymphoid lineage of hematopoietic stem cells?

A 7-year-old boy is infected with influenza virus. His NK cells are activated early in infection. Which of the following BEST explains the mechanism of NK cell–mediated killing?

19-year-old college student presents with fever and sore throat. Monospot test is positive for Epstein–Barr virus (EBV) infection. His immune system initially controls the infection, but weeks later his CD8+ T cells become the dominant effector. Which antigen presentation pathway allowed these CD8+ T cells to recognize EBV-infected B cells?

A 5-year-old boy with recurrent viral and fungal infections is found to have a congenital absence of the thymus. Which of the following cell populations is most directly affected in this patient?