which of the following agents belong to sub class 1

match description to the class of drugs

match description to the class of drugs

match description to the class of drugs:

which of the following drug is not effective for atrial arrhythmias due to very short action potentials ( Na+ channel inactive stage is brief)

match description to the class of drugs

which of the following agents belong to sub class 2

which of the following agents belong to sub class 3

class 1 Na+ channel blockers( fast), will decrease the following

class 1 Na+ channel blockers( fast), will actually INCREASE the following

class 1 Na+ channel blockers( fast), can also decrease phase .......diastolic Na currents which increases threshold to action potential leading to decreased automaticity of abnormal pacemaker activity in cardiomyocytes that depends on Na+ channels

class 1 Na+ channel blockers decrease phase........and phase...........currents.

transition between states depends on

in Tacycardia most of the channels are in the

Class 1 drugs decrease Na+ currents which leads to an/a............in the Effective recovery period

( ERP)

Drugs with a ..........recovery have a greater affect

procanamide, quinidine, and disopyramide have a greater affinity for

flecainide and propafenone have a greater affinity for

Lidocaine and mexiletine have a greater affinity for

Ester was changed t o amide to

metabolites P-aminobenzoic acid and N-acetylprocainamide are the metabolites. the acetylated one is

this drug is available as a racemic mixture. the Tertiary amide can be converted into

name this drug

lidocaine has a rapid onset when administered

lidocaine is a weak with a pKa = 8

the ether in mexiletine is .......stable than the amide of lidocaine because it is more resistant to hydrolysis. ( 1 chiral center)

mexiletine undergoes fist pass metabolism

this drug is primary ...............in the stomach

this drug is primary ...............in the intestines

this drug is administered for V-fib

which drug is this?

flecainide is used to slow down rapid ventricular rates in V-fib. the amide is usually the .......basic moiety of the drug

in disopyramine, the tirtiary amine is ......than the aromatich amine

the S-isomer is mainly responsible for

the secondary amine group is a weak base, and can easily be converted to

in cardiomyocytes class 1 drugs block

ADR of disopyramide include

which of the following Class 1C drugs have extensive and poor metabolizers( genetically determined)

which of the folollowing drugs are not associated with Torsades de pointes ( no significant affect on QT )

Class 1A: match the ADRs to the drug

Class 1A: match the ADRs to the drug

Class 1B: match the ADRs to the drug

Class 1B: match the ADRs to the drug

Class 1C: match the ADRs to the drug

match the drugs to the indication:

match the drugs to the indication:

match the drugs to the indication:

this drug specifically inhibits slow Na+ channels in pacemaker cells, decreases phase 4 spontaneous depolarization , FDA use for CHF and sinus tachycardia & HF. ADRs include bradycardia, AV block, vision changes, and QT prolongation

propanolol, timolol, and sotalol are

atenolol, esmolol, metoprolol are

carvedilol, labetalol are

betaxolol and nebivolol are

acebutolol, penbutolol, pindolol are selective beta blockers, but not used clinically for arrythmias due to

selective B-blocker drugs are less likely to produce

what is the primary affect of b-blockers in pacemaker cells?

what is the primary affect of b-blockers in cardiomyocytes( fast response cells)?

according to the diagram, b-blockers ............cAMP and decrease rate of conduction & force of contraction

which of the following are severe/rare sideeffects of B-blockers

what is the structural difference between beta-Agonists and antagonist ? Beta antagonists have

B-selectivity ...........with increasing size of the R-group

match drug to description

match drug to description

Amiodarone, ibutilde and dofetiled are

What is the MOA of of amiodarone or dofetilde?

what is a disadvantage of amiadorone

dronedarone is an anologue of amiadarone. the removal of Iodine in dronedarone makes the drug

Dofetilide is......... selective compared to amiodarone

Class 3 MOA

which of the following drugs are Class 3 drugs?

which of the following drugs are Class 3 drugs?

of the following drugs , they both have a sulfonamide group, which one has a methanesulfonamide

Class 3 drugs block

an issue with class 3 drugs is that they may cause

if a patient has a QTC > 440msc we should not give them

which of the following class 3 drugs block multiple channels?

which of the following class 3 drugs have class 1,2,3,4 activity( Na,K,Ca++, and beta blocker activity)?

which of the following drugs belong to class 4: blocking activated and inactivated L-type Ca2+ channels in cardiac cells

which of the following class 3 drugs have class 2 and 3 activities ?

which of the following class 3 drugs are known to cause Hyperthyroidism due to IOdine hypersensitiyty, Vision problems, blue ray skin pigmentation, torsades, brady cardia etc ( NASTY drug)

verapamil and diltiazem have their greatest effect in : increasing threshold and slowing depolarization( decreasing SA rate, AV conduction, slowing reentry arrhythmias involving AV node)

verapamil and diltiazem block Ca++ in phase 2 plateu, shorten action potential , prevents DAD + EAD in

verapamil and diltiazem may block Ca++ in later phase 4 and in phase 0, this results in a decrease in

Diltiazem and verapamil will

match MOA to drug: Activates Ach-sensitive K+ channels leading to hyper polarization( SA,AV, atrium), decreasing Ca++ current( decreasing cAMP that occur with sympathetic activation)

match MOA to drug: usually used for arrhythmias: increases vagal tone( indirect action = actiovation of ACh-sensitive K+ channels in atrium( hyperpolorization), shortening APD which decreases Ca++ currents in AV node and increases Effective refractory period

match MOA to drug: usually used for arrhythmias: increases vagal tone( indirect action = actiovation of ACh-sensitive K+ channels in atrium( hyperpolorization), shortening APD which decreases Ca++ currents in AV node and increases Effective refractory period

this drug is a glycoside

common side effects of digoxin include