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WorksheetsPreformulation Studies Quiz
Total questions: 20
Worksheet time: 10mins
What is the primary objective of preformulation studies?
To analyze patient feedback
To generate information for stable dosage forms
To establish drug marketing strategies
To conduct clinical trials
Which statement about Hausner’s ratio is correct?
<1.25 → Poor flow
1.25–1.5 → Good flow
>1.5 → Poor flow
<1.0 → Excellent flow
What is the formula for calculating initial bulk density?
ρb = Weight of powder / Bulk volume
ρb = Weight of powder / Tapped volume
ρb = Bulk volume / Weight of powder
ρb = Tapped volume / Weight of powder
What does Carr's Index indicate?
The particle size distribution
The flow properties of a powder
The solubility of a drug
The melting point of a substance
Which is correct about UV principles?
The unsaturation is must to be detected by UV
Only dilute solutions can be detected
Both
None
How is the angle of repose determined?
By observing the melting point
By calculating the bulk density
By using a spectrophotometer
By measuring the height and radius of a powder pile
What is the significance of the Hausner ratio?
It determines the particle size
It measures the melting point
It assesses the flow properties of powders
It indicates the solubility of a drug
What is the purpose of using a stage micrometer in microscopy?
To measure the temperature
To analyze particle size
To determine the solubility
To calibrate the ocular micrometer
What is the acceptable tolerance for the wavelength scale in UV spectroscopy?
± 0.5 nm
± 3 nm
± 2 nm
± 1 nm
Which chemical is used to determine solubility in acidic conditions?
Methanol
Chloroform
0.1 N HCl
Distilled Water
A higher partition coefficient (P) indicates that the drug is:
More hydrophilic
Insoluble in both phases
Strongly ionized
More lipophilic
What is the purpose of the calibration factor in particle size determination?
To calibrate eye piece with the stage micrometere
To calculate the angle of repose
To determine the solubility
To measure the temperature
What is the method used to determine the partition coefficient?
Using a separating funnel
Using a spectrophotometer
Using a microscope
Using a melting point apparatus
Solubility is
Maximum amount of solute that can be dissolved in a particular amount of solvent
Minimum amount of solute that can be dissolved in a particular amount of solvent
Maximum amount of solute that can be dissolved in a particular amount of solvent at constant temperature and pressure
Minimum amount of solute that can be dissolved in a particular amount of solvent at constant temperature and pressure
What is the maximum number of tappings done if the difference between V1 and V2 is more than 2%?
1000
1250
750
500
What is the first step in the calibration of a thermometer?
Calibration at the melting point
Calibration at room temperature
Calibration at the ice point
Calibration at the boiling point
In partition coefficient determination, the two immiscible solvents used are:
Water and ethanol
Methanol and chloroform
Water and chloroform
HCl and NaOH
What is the flow property classification for an angle of repose less than 25 degrees?
Excellent
Very Poor
Passable
Good
What is lambda max?
It is the maximum wavelength of a compound
wavelength at which the compound shows maximum absorbance
Absorbance at which the compound shows maximum wavelength
It quantifies the absorbance of a solution
Particle size distribution using microscopy requires analysis of minimum:
100 particles
200 particles
500 particles
625 particles
