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Quiz on OP Poisoning and Related Compounds

Total questions: 50

Worksheet time: 17mins

Name
Class
Date
1.

Which enzyme is inhibited by organophosphate compounds?

a)

Monoamine oxidase

b)

Acetylcholinesterase

c)

Cytochrome oxidase

d)

Sucrase

2.

The antidote of choice in OP poisoning is:

a)

Pralidoxime

b)

Atropine

c)

Ethanol

d)

Magnesium sulfate

3.

The classical clinical mnemonic for OP poisoning includes:

a)

SLUDGE

b)

ABCDE

c)

SAMPLE

d)

RACE

4.

SLUDGE stands for:

a)

Salivation, Lacrimation, Urination, Diarrhea, Gastrointestinal upset, Emesis

b)

Sweating, Lethargy, Unconsciousness, Diarrhea, Giddiness, Emesis

c)

Shock, Liver toxicity, Unconsciousness, Dehydration, Gastrointestinal upset, Encephalitis

d)

Salivation, Liver toxicity, Urination, Dystonia, Generalized edema

5.

Occupational exposure to OP compounds is most common in:

a)

Industrial workers

b)

Farmers

c)

Healthcare workers

d)

Teachers

6.

Which drug reactivates acetylcholinesterase in OP poisoning?

a)

Atropine

b)

Pralidoxime

c)

Naloxone

d)

Phenobarbital

7.

DUMBBELSS in OP poisoning stands for all except:

a)

Diarrhea

b)

Miosis

c)

Bradycardia

d)

Tachycardia

8.

Mechanism of OP toxicity primarily involves:

a)

Irreversible inhibition of acetylcholinesterase

b)

DNA synthesis suppression

c)

Enzyme induction

d)

Competitively antagonizing GABA

9.

In OP poisoning, atropine is administered until:

a)

Pupils dilate

b)

Heart rate is >80/min and chest is clear

c)

Sweating stops

d)

Patient is sedated

10.

Which of the following is NOT used in OP poisoning therapy?

a)

Atropine

b)

Pralidoxime

c)

Activated charcoal

d)

Acepromazine

11.

Carbamate compounds inhibit which enzyme?

a)

Monoamine oxidase

b)

Acetylcholinesterase

c)

Cytochrome oxidase

d)

Glutathione peroxidase

12.

Carbamate toxicity lasts for:

a)

Several weeks

b)

Months

c)

Less than 24 hours

d)

Indefinitely

13.

Symptoms of carbamate poisoning resemble those of:

a)

Alkaloid poisoning

b)

Organophosphate poisoning

c)

Metal toxicity

d)

Vitamin deficiency

14.

The primary treatment for carbamate poisoning is:

a)

Broad-spectrum antibiotics

b)

Decontamination and supportive care

c)

High-dose steroids

d)

Insulin therapy

15.

Which antidote is occasionally used for carbamate toxicity?

a)

Atropine

b)

Diazepam

c)

Naloxone

d)

Phenobarbital

16.

Pralidoxime is:

a)

Always required in carbamate poisoning

b)

Recommended only for severe cases

c)

Never used in carbamate poisoning

d)

Used for all pesticide poisoning

17.

The most common cause of death in carbamate poisoning is:

a)

Liver failure

b)

Respiratory failure

c)

Kidney failure

d)

Heart attack

18.

Which among the following is a carbamate pesticide?

a)

Parathion

b)

Captan

c)

DDT

d)

Malathion

19.

Nicotinic effects of carbamate poisoning include:

a)

Tachycardia

b)

Muscle fasciculations

c)

Bronchospasm only

d)

None

20.

Carbamates cause:

a)

Covalent binding to acetylcholinesterase

b)

Reversible binding to acetylcholinesterase

c)

No enzyme inhibition

d)

Permanent toxicity

21.

Organochlorines are classified as:

a)

Biodegradable

b)

Persistent organic pollutants

c)

Insect repellents

d)

Parasite inhibitors

22.

Which is an example of an organochlorine pesticide?

a)

DDT

b)

Malathion

c)

Carbaryl

d)

Aldicarb

23.

Organochlorine exposure is associated with:

a)

Neurotoxicity

b)

Hypercholesterolemia

c)

Diabetes mellitus

d)

Hypothyroidism

24.

The collective term DDX refers to:

a)

DDT, DDE, DDD

b)

DDT, DDA, DDP

c)

DDA, DDB, DDC

d)

DDA, DDE, DDO

25.

Organochlorines act mainly by:

a)

Inhibiting sodium channels

b)

Activating potassium channels

c)

Impairing GABA synthesis

d)

Blocking calcium channels

26.

Which organ system is primarily affected by chlorinated cyclodienes?

a)

Hepatic

b)

Renal

c)

Pulmonary

d)

Gastrointestinal

27.

Most organochlorines are:

a)

Quickly biodegradable

b)

Non-persistent

c)

Rapidly excreted

d)

Environmentally persistent

28.

Health risks of organochlorines include all except:

a)

Endocrine disruption

b)

Carcinogenicity

c)

Neurotoxicity

d)

Hyperglycemia

29.

Organochlorines are mainly used as:

a)

Herbicides

b)

Antibiotics

c)

Pesticides

d)

Fungicides

30.

Alternatives to organochlorine pesticides include:

a)

Organo-phosphates

b)

Alkaloids

c)

Heavy metals

d)

None

31.

Aluminium phosphide poisoning primarily occurs due to:

a)

Inhalation

b)

Ingestion

c)

Contact with skin

d)

Injection

32.

Fatal dose of aluminium phosphide is:

a)

10 gm

b)

5 gm

c)

3 gm

d)

1 gm

33.

Aluminium phosphide poisoning is associated with characteristic:

a)

Apple odor

b)

Garlic odor

c)

Fish odor

d)

Banana odor

34.

Phosphine gas is liberated from aluminium phosphide when:

a)

Heated

b)

Exposed to dry air

c)

Exposed to moisture

d)

Kept in sunlight

35.

Mechanism of toxicity of aluminium phosphide includes:

a)

Inhibition of acetylcholinesterase

b)

Inhibition of cytochrome oxidase in mitochondria

c)

Stimulation of beta-adrenergic receptors

d)

Altered DNA methylation

36.

Clinical features of aluminium phosphide poisoning include:

a)

Myocarditis, hypotension, and shock

b)

Chronic liver disease

c)

Seizures only

d)

Hypokalemia only

37.

The recommended breath test for phosphine gas detection involves:

a)

Silver nitrate turning black

b)

Sulfuric acid forming white fumes

c)

Potassium permanganate forming violet color

d)

Copper sulfate forming green color

38.

Garlic odor in aluminium phosphide poisoning is also seen in:

a)

Arsenic poisoning

b)

Carbamate poisoning

c)

Cyanide poisoning

d)

Lead poisoning

39.

Complications of aluminium phosphide poisoning commonly involve:

a)

Acute liver failure

b)

Acute respiratory failure

c)

Cardiovascular collapse

d)

Renal failure

40.

Aluminium phosphide poisoning can cause all except:

a)

Subendocardial infarction

b)

Esophageal stricture

c)

Accumulation of acetylcholine at NM junction

d)

Metabolic acidosis

41.

OP compounds used as pesticides include:

a)

Parathion

b)

Aldrin

c)

DDT

d)

Captan

42.

Carbamate pesticides include:

a)

Aldicarb

b)

Parathion

c)

DDT

d)

Lindane

43.

Organochlorine induces what type of toxicity?

a)

Renal

b)

Neurotoxicity

c)

Haematological

d)

Cardiac

44.

Aluminium phosphide poisoning causes metabolic acidosis mainly due to:

a)

Lactic acid accumulation

b)

Ketosis

c)

Uric acid accumulation

d)

Hypoglycemia

45.

Most OP and carbamate poisonings affect the:

a)

Muscarinic and nicotinic receptors

b)

Only nicotinic receptors

c)

Only muscarinic receptors

d)

Only adrenergic receptors

46.

The main focus in acute carbamate poisoning treatment is:

a)

Maintenance of airway

b)

Renal support

c)

Antibiotic therapy

d)

Diuretic therapy

47.

Organochlorine pesticides are best analyzed using:

a)

Electron Capture Detector

b)

UV spectrometry

c)

Chromatography

d)

Radioimmunoassay

48.

DDT is referred to chemically as:

a)

Dichlorodiphenyltrichloroethane

b)

Dimethyltrichloroethane

c)

Diaminotriphenylethane

d)

Dehydrodiphenyltrichloroethane

49.

Phosphine gas is confirmed in breath by which test?

a)

Silver nitrate paper

b)

Benzidine reaction

c)

Melzer's reagent

d)

Copper sulfate paper

50.

The fatal period of aluminium phosphide poisoning is typically:

a)

72 hours

b)

24 hours

c)

48 hours

d)

12 hours