WorksheetsPharm II Exam I
Total questions: 219
Worksheet time: 2hrs 29mins
Which of the following are used for sickle cell anemia?
hydroxyurea
hydrocychloroquine
buprenophrine/naloxene
aminocaprioc acid
desmopression
Which of the following are used for hemophilia?
hydroxyurea
hydrocychloroquine
buprenophrine/naloxene
aminocaprioc acid
desmopression
PT education for buprenophine/naloxene
this decreases pain by working on your mood receptros
this decreases pain by suppressing the CNS
this will give you a euphoric experience
this is teratogenic
this will prevent your cells from sickling by inhibiting s-phase
PT education for buprenophine/naloxene
this decreases pain by working on your mood receptros
this decreases pain by suppressing the CNS
this will give you a euphoric experience
this is teratogenic
this will prevent your cells from sickling by inhibiting s-phase
PT education for hydroxyurea
this decreases pain by working on your mood receptros
this decreases pain by suppressing the CNS
this will give you a euphoric experience
this is teratogenic
this will prevent your cells from sickling by inhibiting s-phase
CAR-T cells complications
Hepatic complications
monitor for anaphylaxis
risk for cytokine release syndrome
hypotension/fever
GI distress
Monoclonal antibodies
Hepatic complications
monitor for anaphylaxis
risk for cytokine release syndrome
hypotension/fever
GI distress
T/f. Tacrolimus would not be necessary following a stem cell transplant.
true
false
filgrastim
cancer patients must be cancer free
boosts aldosterone
builds up WBC
monitor for bone pain
synthetic keratin
Palifermin
synthetic keratin that increases epithelial tissues
white tongue rule out thrush
given to help prevent hair loss from chemo
given to help reduce mucositosis/stomatitis to prevent ulcerations
may cause photosensitivity
Drugs that end in "-alidomine"
multiple myeloma
pheochromocytoma
teratogenic
bone marrow suppress->no angiogenesis
reduces catecholamines
what orders whould the nurse expect to see when her patient is taking "-alidomine"
CBC
Blood thinner medication
gabapentin for nerve pain
BMP
24 hour urine
which medications are used for allergies
fosphenytoin/phenytoin
certrizine
beclomethasone/corticosteroid nasal spray
phenylephrine/pseudophedrine
montelukast
which medication should you monitor elderly patients closely for neurologigical effect (beers list)?
fosphenytoin/phenytoin
certrizine
beclomethasone/corticosteroid nasal spray
phenylephrine/pseudophedrine
montelukast
which medication can make you feel jittery or cause rebound drip/congestion if taken nasally?
fosphenytoin/phenytoin
certrizine
beclomethasone/corticosteroid nasal spray
phenylephrine/pseudophedrine
montelukast
which medication can cause epitaxis
fosphenytoin/phenytoin
certrizine
beclomethasone/corticosteroid nasal spray
phenylephrine/pseudophedrine
montelukast
when providing patients education on diphenydramine what should be included
it has more CNS antagonist effects than certrizine
it has less CNS antagonist effects than certrizine
it can cause a paradoxyl effect
if taken frequently it can cause urine hesitation
it blocks inflammation
what drugs might be prescribed for a patient suffering from rheumatoid arthritis
methotrexate
mannitol
sulfasalazine
hydrocychloroquine
colchicine
what patient education should be provided for patients on methotrexate
you need to use a micronfilter on IV
takes weeks to months to build up
it inhibits folate if you were to become pregnant your baby would be at risk for spinal/neuro complications
it may cause fibrosis especially in liver and lungs
you should update your vaccinations because you are at increased risk for infection
what patient education should be provided for patients on methotrexate
you need to use a micronfilter on IV
takes weeks to months to build up
it inhibits folate if you were to become pregnant your baby would be at risk for spinal/neuro complications
it may cause fibrosis especially in liver and lungs
you should update your vaccinations because you are at increased risk for infection
sulfasalazine
monitor for chest pain due to vasoconstriction
aspirin family monitor for infections
bone marrow suppression
stops folate synthesis to preven DNA formation
can also work for lupus patients
hydrocychloroquine
can cause retinal damage
agranulocytosis
anemia
enzymes stop DNA synthesis
thrombocytopenia
T/F. Hydrocychloroquine is also effective for lupus
true
false
what are medications used for gout
sodium ziroconium
aluminum carbonate
allopurinol
calchicine
clonidine
calchicine
used for chronic gout
used for acute gout
may cause bone marrow suppression
risk for rabdo
risk for cushings triad
-zomib
stops protein synthesis
bone marrow suppression
weak
neuropathy
prophylactic blood thinners
thyrotoxic crisis/storm
lugol solution
methimazole
PTU
liothyronine
levothyroxine
hyperthyroidism
lugol solution
methimazole
PTU
liothyronine
levothyroxine
hypothyroidism
lugol solution
methimazole
PTU
liothyronine
levothyroxine
can cause liver failure/agranulocytosis
lugol solution
methimazole
PTU
liothyronine
levothyroxine
teratogenic/wear gloves
lugol solution
methimazole
PTU
liothyronine
levothyroxine
Hypothyroid Crisis/Myxedema Coma
lugol solution
methimazole
PTU
liothyronine
levothyroxine
levothyroxine education
take in AM on empty stomach or 2 hours after eating
monitor for thyrotoxicosis
take at night
T3
T4
lliothyronin education
take in AM on empty stomach or 2 hours after eating
monitor for thyrotoxicosis
take at night
T3
T4
Hypoadrenal gland/addisons
Potassium Cocktail
Hydrocortisone/cortisone/predisone
dexamethasone
fludrortisone
Mitotame
Dexamethason/methylpredisone
has both gluccocrticoids/mineralcorticoids
only has gluccorticoids
combine with filgrastim
combine with fludrocortsione
best for respiratory infections
hydrocortisone/cortisone/predisone
has both gluccocorticoids/mineralcorticoids
take in the AM
take with food or milk
mineralcorticoid mostly some gluccocorticoid
improves cravings for salt and water
fludrocortisone
has both gluccocorticoids/mineralcorticoids
take in the AM
take with food or milk
mineralcorticoid mostly some gluccocorticoid
improves cravings for salt and water
Hyperkalemia Cocktail for Addsions
insulin
dextrose
bicarb
calcium
sodium zirconium
Hyper-Andrenal Function/Cushings
clonidine
mitotane
mannitol
ketocanazole
steroids
mitotane
stops cortisol secretion in adrenal tissue
stops cortisol secretion in anterior pituitary
stops PTH from being released
clonidine
pheochromocytoma
for hyper-andrenal crisus
for hypo-adrenal crisis
for myxedema come
clonidine acts on
catecholamines
cortisol
ADH
aldosterone
Hyper-paraythroid
calcitonin
alendronate
aluminum carbonate
calcium/vitamin D
calcitonin
hypercalcemia
hypocalcemia
hyperkalemia
hypokalemia
aldrenonate
reduces osteoclast
sit up RIGHT
stops all PTH secretion
only stops PTH secretion from bone
monitor for esophagitis
aluminium carbonate lowers
phosphorus
calcium
potassium
sodium
hypo-secretion ADH/Diabietes insipidus
desmopressin
demeclocycline
conivaptan
diphenhydramine
hyper-secretion ADH/SIADH
desmopressin
demeclocycline
conivaptan
diphenhydramine
SIADH crisis
desmopressin
demeclocycline
conivaptan
diphenhydramine
demeclocycline
photosensitivity
super-infections
monitor hypovalemia
pulmonary edema
conivaptan considerations
hypervalemia
hypovalemia
monitor weights
ICP medications
mannitol
hypertonic solution
hypotonic solution
levetiracetam
corticosteroids
mannitol
micronfilter
diureses them
stops folate production->teratogenic
hypotension
risk for pulmonary edema
levetiracetam
decrease ICP
antiseizure
muscle weakness
reduces inflammation caused by leaky tumors
corticosteroids
decrease ICP
antiseizure
muscle weakness
reduces inflammation caused by leaky tumors
fosphenytoin/phenytoin
delays growth and development
purple glove syndrome
gingival hyperplasia->horse gums
causes sedation
long-term CNS effects- nystagumus and diplopa
phenobarbital
delays growth and development
purple glove syndrome
gingival hyperplasia->horse gums
causes sedation
long-term CNS effects- nystagumus and diplopa
Carbamazepine
treats CN neuralggia and seizures
bone marrow suppression
increases ADH
decreases ADH
temporary CNS effects
lamotrigine
aseptic meningitis
liver failure
pancreatitis
works on bicarbonate->risk for kidney stones and metabollic acidois
monitor for pursed lips/ABG
valproate/valporic acid
aseptic meningitis
liver failure
pancreatitis test enzyme function
works on bicarbonate->risk for kidney stones and metabollic acidois
monitor for pursed lips/ABG
topiramate
aseptic meningitis
liver failure
pancreatitis test enzyme function
works on bicarbonate->risk for kidney stones and metabollic acidois
monitor for pursed lips/ABG
what stops a seizure
fosphenyton/phenytoin
phenorbarbital
benzos
phenylephrine/psuedophedrine
lamotrigine
what meds would be used for seizure
carbamazepine
lamotrigine
valproate/valmoric acid
topiramate
levetiracetam
what meds would be used for headache/migraine
suma
ergotomine
valproate/valmoric acid
topiramate
levetiracetam
sumatriptan
monitor for chest pain
causes vasoconstiction
causes vasodilation
no constriction but peripheral effects monitor chest
nausea/vomit
ergotomine
monitor for chest pain
causes vasoconstiction
causes vasodilation
no constriction but peripheral effects monitor chest
nausea/vomit
pernicious anemia body can't absorb
B9
B12
iron
What can cause anemia
autoimmune hemolysis
chemo medications
hyperspleenism
heart failure
liver disease
thalessemia
more common in black/mediterranean people
Protein chain in RBC don’t form a RBC
body attacks red blood cells
Genetic disorder
t/f. crohns patients are more at risk for developing anemia because can't absorb B9/folic acid
true
false
S/S of anemia
Hypotension
tingles and neuropathy
Glossy tongue
Respirations/heart rate increase
Hypertension
Anemia Testing
BMP/CMP
Ultrasound
EPO Levels
Bone marrow biopsy
colonoscopy/edoscopy/occult
priority interventions for anemia
Safety for falls
Supplement iron/B9/B12
Blood transfusion
O2 therapy
IV fluids
Parenteral Iron
Monitor for anaphylactic shock
Assess BP ever 15 minutes
Has to be in clinic
Take with OJ
Take with milk
B12
IM injections
Metformin blocks absorption
Alcoholics need parenteral
B9
IM injections
Metformin blocks absorption
Alcoholics need parenteral
what would be important patient education when someone who is anemic started b9/b12/iron therapy
IM injections will make you feel better instantly
it can take a few weeks to replenish stores
these will need to be lifelong interventions
you can stop when you feel your fatigue has gone away
having a well-rounded diet can also help
what could induce Sickle Cell Anemia
COPD/smoking
Trauma
High altitude
Lack of fluids
Sickle Cell Assessment
Lower leg
Neuropathy
Jaundice
Puiritis
Blindness
Sickle Cell Assessment
Dysrhythmia
Acute chest
Cushings triad
Stroke
Priapism
what would some orders a nurse might have on order for sickle cell
12 EKG normal
X-ray for infiltrations
Hydroxyurea
opiods
Hydrolochloroquine
if a patient is receiving a blood transfusion for symptomatic anemia the nurse should
collect history the more infusions the higher chances of transfusion reaction
must take vitals
stay 15 minutes
make sure informed consent is get
will give if HH is greater than 7
Thrombocytopenia causes
H. pylori
Petechiae
Obstructive sleep apnea
heparin/bloodthinners
Hemophilia A/B
Don’t make factor 5 or 8
Biggest problem is bleeding into tissue
Ask how severe?
inherited
If overclotting, “donate” wont use/remove blood
Polycythemia causes
Chronically hypoxic
heart failure
high altitude
Tumor on adrenal gland
Leukemia
Anemia
Thrombocytopenia
Leukopenia
Overproduction of leukocytes/prolonged leukocytosis
Cancer of lymph tissue
T/F. Acute lymphoid leukemia (ALL) more common in children will more than likely be genetic
Chromosome 9 and 23
true
false
Clinical manifestations of leukemia
bleeding
Bone pain overproduction
Infection like symptoms
Swollen lymph nodes/enlarged spleen and liver
Jaundice
Diagnostic test for leukemia
CBC with differential
Clotting factors
Bone marrow biopsy
X-rays
Viral testing
Mono
HIV
Stem cell transplants
Peripheral blood of umbilical cord harvests stem cells
High dose of chemo to knock everything out-> healthy cells are infused into the patient's bloodstream
quick recovery
Engraftment syndrome
Graft versus host
Nursing interventions for all leukemia/lymphoma or chemo patients
Prophylactic therapy
Avoid antiplatelets/anticoagulants
neutropenic precautions if neutrophils less than 500
Monitor Output
.5 kg/HR
Blood transfusion PRN
Lymphoma
Reed-Sternberg cells differentiate (RARE)
Epstein bar/MONO
Fever
Nigh sweats
Unplanned weight gain
Stage 1 Lymphoma
isolated to one spot above diaphragm
multiple spots same side above diaphragm
above below the diaphragm on same side
multiple organ involvement
Stage 2 Lymphoma
isolated to one spot above diaphragm
multiple spots same side above diaphragm
above below the diaphragm on same side
multiple organ involvement
Stage 3 Lymphoma
isolated to one spot above diaphragm
multiple spots same side above diaphragm
above below the diaphragm on same side
multiple organ involvement
Stage 4 Lymphoma
isolated to one spot above diaphragm
multiple spots same side above diaphragm
above below the diaphragm on same side
multiple organ involvement
Assessment Lymphoma
Ultrasound biopsy
CT to see lymph involvement
PET tag RBC cells to see O2 supply light
Bone marrow biopsy
CBC with differential
Multiple Myeloma cancer is the
RBC
WBC
plasma
platelets
Multiple Myeloma
Decreased
RBC
WBC
Platelets
Serum protein
Multiple Myeloma
increased
RBC
WBC
Platelets
Serum protein
Multiple Myeloma
Extreme bone pain/fractures
fatigue/anemia
Kidney dysfunction
swollen lymphs
Assessment for multiple myeloma
CT to see lymph involvement
PET
Bone marrow biopsy
CBC with differential
Serum protein
Leukocytes in allergies
Goal is to identify invaders and build memory cells but when in overdrive and produce too fast causes more damage and attack the wrong thing
1st time won’t have an allergic reaction don’t antibodies yet
IgE antibodies causes most reactions
can have range of symptoms
Hypersensitivity
Type 1
food/environment
transfusion reaction, someone elses antibodies
body over exaggerated immune over drive
lupus/rheumatoid
delayed
Graft v host
Hashimotos
Hypersensitivity
Type 2
food/environment
transfusion reaction, someone elses antibodies
body over exaggerated immune over drive
lupus/rheumatoid
delayed
Graft v host
Hashimotos
Hypersensitivity
Type 3
food/environment
transfusion reaction, someone elses antibodies
body over exaggerated immune over drive
lupus/rheumatoid
delayed
Graft v host
Hashimotos
Assessment Allergy
CBC with differential
IgE serums
Penicillin allergy testing introduce penicillin intradermally
Sputum culture
allergy shots
t.f. for patient education don’t have anti-histamine meds for a few days before allergy testing
true
false
Moderate/Severe Allergies
bronchospams->stridor upper airway closing EMERGENCY
Resemic epi stronger than duoneb
Edema of airway from inflammation
Hypotension-> risk for shock
Cardiac arrest
what can we do for allergies
SPO2/BP STAT
Monitor for accessory or distress
Will be tachycardic
Will be bradycardic
get a rapid response
Anaphylaxis Interventions
1:1000 or .3 mg IM
Different than code cart
IV fluids to keep BP
Intubate if needed
diphenhydramine IV
Epi education
Remove blue safety cap
Multi-use
One time use
Large muscle at 90 degree in thigh
Hold for 10 second and massage 10 seconds
Inflammation Lab for anything
Antinuclear antibody ANA
C reative protein
Erythrocyte sedimentation rate ESR
CBC
Rheumatoid factor lab
Antinuclear antibody ANA
indicates inflammation in tissue
causes liver to make a glycoprotein
Normal blood sinks to the bottom this measures how fast they sink-> the more inflammation the faster they sink
WBC differential
C reative protein
indicates inflammation in tissue
causes liver to make a glycoprotein
Normal blood sinks to the bottom this measures how fast they sink-> the more inflammation the faster they sink
WBC differential
Erythrocyte sedimentation rate ESR
indicates inflammation in tissue
causes liver to make a glycoprotein
Normal blood sinks to the bottom this measures how fast they sink-> the more inflammation the faster they sink
WBC differential
CBC
indicates inflammation in tissue
causes liver to make a glycoprotein
Normal blood sinks to the bottom this measures how fast they sink-> the more inflammation the faster they sink
WBC differential
Rheumatoid arthritis
Breaks down collagen and bone damage can be permanent=pannus and cause deformities
Joints may be red/hot
Pneumonitis
Myocarditis
Valvular incompetence
Rheumatoid arthritis ASSESSMENTs
Rheumatoid factor lab
Anti-DNA
BMP
Bone scans to measure damage
Uric acid levels
Systemic Lupus Erythematosus
Butterfly rash
Raynauds: occludes vessels decreases perfusion
Pneumonitis
Myocarditis
Pericarditis
Systemic Lupus Erythematosus
CNS/psychosis
Strokes lack of perfusion
Seizure inflammation in nerves cause misfires
Swollen lymph
Renal nephritis
Systemic Lupus Erythematosus Assessment
ANA
Anti-DNA
CBC
BMP
24 hour urine
Gout
Synovial fluid aspiration
Anti-DNA
urine/blood
BMP
24 hour urine
Gout
autoimmune
Overtime cause joint issues/arthritis
inflammatory disease
Uric acid crystals that accumalate and cause massive inflammation
Diet/
Impaired renal excretion
Gout Assessment
Pain/
Swelling
Tenderness
Warmth
usually bilaterally
usually one side
ADH function
don’t pee hold on to fluid
Says to pee cause extra fluid in heart it’s not fluid volume issue it’s a pressure issue
Kidney is looking for fluid vasocontricts to increase flow back to the kidney
Renin-angiotensintensin
don’t pee hold on to fluid
Says to pee cause extra fluid in heart it’s not fluid volume issue it’s a pressure issue
Kidney is looking for fluid vasocontricts to increase flow back to the kidney
Atrial natriuretic peptide BNP
don’t pee hold on to fluid
Says to pee cause extra fluid in heart it’s not fluid volume issue it’s a pressure issue
Kidney is looking for fluid vasocontricts to increase flow back to the kidney
Diabetes
don’t pee hold on to fluid
Says to pee cause extra fluid in heart it’s not fluid volume issue it’s a pressure issue
Kidney is looking for fluid vasocontricts to increase flow back to the kidney
electrolytes and ions base
If anion gap closes indicates acid/base balance
t/f. BMP only measures what's outside the cell
true
false
OUTSIDE the cell
Sodium
Chloride
Calcium
Bicarbonate
Potassium
INSIDE the cell
Magnesium
Chloride
Calcium
Phosphorus
Potassium
Interventions for electrolyte imbalances
I/O’s
Bladder scan
Acid balance base
24 hour urine for hormone secretion
BMP
Isotonic
D5W dextrose
Normal saline .9%:
Lactated ringers:
0.45%
3%
Hypertonic
Common for brain pressure draws fluid out and shrinks cell, decreasing intracranial pressure
Small amount given to shrink cells
Should never be an standing order
Monitor BMP for NA closely
Hypernatremia
Hypotonic
Common for brain pressure draws fluid out and shrinks cell, decreasing intracranial pressure
Small amount given to shrink cells
Should never be an standing order
Monitor BMP for NA closely
Hypernatremia
Hypoactive Thyroid
HIGH TSH
LOW TSH
HIGH T3/T4
LOW T3/T4
Hyperactive Thyroid
HIGH TSH
LOW TSH
HIGH T3/T4
LOW T3/T4
Thyroid Tests
TSH
Test T3 and T4
Radioactive iodine uptake test
Thyroid antibodies
Fine needle aspiration of the thyroid
t/f. Hypothyroidism patients at risk for pneumonia/atelectasis because respirations are depleted do a chest x-ray
true
false
Hyperthyroid S/S
hot/warm
Skinny
High heart rate/BP
nervous/shaking
waxy skin
Plummer disease
Benign goiter that accumulates on thyroid still push/plug to release more T3/T4
If causing problem have surgically removed
hyperthyroidism
hypothyrdoism
autoimmune
Fine needle aspiration of thyroid
Consent
monitor for signs of bleeding
Ask about blood thinner
Monitor for bleeding into the airway
NPO
inteventions for hyperthyroid
Telemetry
High cal diet
eye drops
calm environment
warming blankets
Thyrotoxic crisis/Thyroid storm
Too much T3/T4
Too little T3/T4
Tachycardia/Tachypnea
Hyperthermia
Cardiogenic shock
Iron PO
take on empty stomach
take with juice
use straw
monitor anaphylaxis
must be done as patient not at home
Iron IV
take on empty stomach
take with juice
use straw
monitor anaphylaxis
must be done as patient not at home
causes of hypothyroidism
Thyroiditis
Tumors push/plug on anterior pituitary
autoimmune
aging
head/neck radiation
Hypothyroidism
S/S
Chronically cold
Constipated
Hypoglycemia
Hyperglycemia
Elevate cholesterol can’t metabolize fats
Hypothyroid Crisis/Myxedema Coma Emergency
Hypothermia
Hypoventiliation
Bradycardia
Coma
EKG changes
Thyroid Nodules
pushing or plugging T3/T4
benign or malignant
Enlarged thyroid
thyroid atrophy
if causing a problem remove
Thyroidectomy/parathyroidectomy
Consent needed
Remove thyroid/Relocate parathyroid if cancer free
Monitor for calcium levels
Blood type and screen
monitor airway for patency or bleeding
Thyroidectomy/parathyroidectomy patient education
Weight restriction on head and neck
Don’t bend over
don't brush your teeth
nose packing
CBC/HH to monitor for bleeding
Hyperparathyroidism
MOANS GROANS STONES
Hypocalcemia
Hypercalcemia
Sedative effects
tight contracted
Hypoparathyroidism
MOANS GROANS STONES
Hypocalcemia
Hypercalcemia
Sedative effects
tight contracted
Hyperparathyroidism Assessment
BMP
Double antibody test for PTH
Ultrasound for tumor
Needle biopsy
X-ray
Hyperparathyroidism Assessment
fractures/deformities
renal calculi
Arrhythmia
Pancreatitis CA+ deposits cause inflammation
Bronchospasms->wheezing
Hypoparathyroidism
Dysrhythmia
EKG
Tentany
Bronchospasms->wheezing
Muscle hypertonia- rigidity
Risk for fractures
Adrenal Glands
T3
T4
aldosterone
cortisol
ADH
posterior pituitary
T3
T4
aldosterone
cortisol
ADH
Cortisol/glucocorticoid
Vasoconstriction keeps things from leaking
Energy
Fluid/electrolyte balances
aldosterone
Vasoconstriction keeps things from leaking
Energy
Fluid/electrolyte balances
Addisons disease/Hypofunction of adrenal gland
High Potassium
Decrease NA/H2O
Decrease Potassium
increased NA/H2O
dehydrated/weak/confused
Peak t-wave
Anorexia/weightloss
Causes of hypo/hyperthyroidism
trauma/tumor on anterior pituitary
trauma/tumor
Adrenal gland dysfunction
autoimmune
Assessment of adrenal issues
Serum cortisol/Serum osmolarity
BMP
aldosterone/renin levels
24 hour urine
ACTH
Hyperparathyroidism
ISOTONIC IV fluids pee it out
D5/ normal saline
addisons
ISOTONIC IV fluids pee it out
D5/ normal saline
addisons intervention
monitor BP
monitor for cardiac arrest
Decreased vasoconstriction everything leaks out
Telemetry
monitor cbc
Cushing/Hyperfunction of adrenal gland
Holding NA/H2O
Excreting potassium
Excreting NA/H2O
holding potassium
Long-term steroid use-most common
Cancer
Autoimmune
Suppressed immune system because of steroid usage
Cushing/Hyperfunction of adrenal gland
Hyperlipedema
Hypertension
CAD
risk for breakdown/fragile skin
Ulcers inhibits prostaglandin no protective mucosa
Cushing/Hyperfunction of adrenal gland
Loss of muscle mass
Fat redistribution
Stops calcium absorption risk for osteoporosis
Central obesity/buffalo hump
Moodswings
Personality changes
Cushing interventions
insulin for hyperglycemia
Balanced I/Os
skin checks
safety for fractures
increase protein
Hypophysectomy
Removes pituitary
nose packing
don't brush teeth
don't bend forward
removes adrenal gland(s)
Adrenalectomy
Just need 1 adrenal to live
Will need to supplement cortisol and aldosterone in the beginning until other catches up
will only need to supplement aldosterone ACTH will still make cortisol
Pheochromocytoma
Tumor on adrenal gland-> overproduces epinephrine and norepinephrine (catecholamine)
Tumor on thyroid-> overproduces epinephrine and norepinephrine (catecholamine)
Tumor on pituitart-> overproduces epinephrine and norepinephrine (catecholamine)
24 hour urine
CT to find tumor
Pheochromocytoma S/S
Headache
Hyperhidrosis/sweaty
Hypertension
Hypermetabolism
Hyperglycemia
Diabetes insipidus
NOTHING to do with blood sugar
NOT ENOUGH ADH
TOO MUCH ADH
elevated serum osmolarity/
decreased urine serum
decreased serum osmolarity/
elevated urine serum
SIADH
NOT ENOUGH ADH
TOO MUCH ADH
elevated serum osmolarity/
decreased urine serum
decreased serum osmolarity/
elevated urine serum
Diabetes Insipidus
Water deprivation test
BMP- could be elevated or not
hypertonic solution
24 hour urine test
hypotonic solution
SIADH causes
Bronchogenic carcinoma can synthesize and store ADH in the lungs
Pancreatic carcinoma can synthesize and store ADH
Meds
MDMA/ecstasy
SSRIs
Meds
lithium/alcohol
SIADH SS
seizures
Increase BP
Edema
JVD
Crackles respiratory
diarrhea
SIADH Interventions
restrict fluids
hypertonic solution
diuresis
monitor BP
hypotonic solution
ICP
Pressure has nowhere to go but down putting pressure on respiratory system and stops breathing
Swelling effects work their way down the brainstem with coordinating effects
Order operation assessment
LOC
ADH changes
Eyes CN 3 and 4
face/auditory CN 5 6 7 8
CN 9 10 11 12
Order operation assessment
LOC
ADH changes
CN 9 10 11 12
Eyes CN 3 and 4
face/auditory CN 5 6 7 8
Monroe-kellie Hypothesis
CSF shifts to spinal
Blood shifts
Tissue shifts
Tissue shifts
Blood shifts
CSF shifts to spinal
Blood shifts
Tissue shifts
CSF shifts to spinal
ICP
Normal ICP 5-15
straining can increase
constriction and dilation controls
constriction decreases
dilation
decreases
Cerebral Perfusion Pressure
Metabolic needs for the brain
keep between 70-100 CPP
MAP (SBP+DBx2) - ICP
Need art line
keep 5-15
Causes of ICP
Lesions
Head injury
Inflammation/infections
Lack of perfusion
leaky tumor
SS of ICP
Vision changes
Papilledema- brain out of eyes
Projectile vomiting
Cushings triad
Uncle herniation- unilateral
Cushings triad
widening of pulse pressure->systolic increases->trying to get up to the brain->body tries to slow things down to balance and turn bradycardiac-> changes in respirations Cheyne Cheyne-Stokes/apneic/ataxic
compressed of pulse pressure->systolic increases->trying to get up to the brain->body tries to slow things down to balance and turn bradycardiac-> changes in respirations Cheyne Cheyne-Stokes/apneic/ataxic
Interventions for ICP
Posture/leave alone
map-pressor/titrate drips
get head CT
lumbar puncture
bone biopsy
ICP Waveform
measures p1, p2, p3
measures neuron firing
measures ICP through CSF fluid
Electroencephalogram (EEG)
measures p1, p2, p3
measures neuron firing
measures ICP through CSF fluid
Ventriculostomy measures
measures p1, p2, p3
measures neuron firing
measures ICP through CSF fluid
Lumbar Puncture for ICP considerations
CT first
Assess for blood thinners
A shift can cause a herniation
risk for bleeding
Decreased Cerebral Blood Flow
Elevates ICP
Cells swell and die
Intra-abdominal/Intra-thoracic pressure forces air in:
Collapsed lung
Ventilator
Flexed position occludes flow
CO2 high
decrease ICP
Interventions for cerebral perfusion issue due to ICP
Life support
Put O2/oxymask
Sedative to reduce metabolic needs
Seizure precautions neurons overfire
Monitor I/Os-> ADH impacts
Intracranial surgeries- when ICP won’t go down
Craniotomy
Skull cap off
Remove the tumor or clot
EVD device catheter
Aspirate clot or abcess
Scope up nose
Intracranial surgeries- when ICP won’t go down
Buur holes
Skull cap off
Remove the tumor or clot
EVD device catheter
Aspirate clot or abcess
Scope up nose
Intracranial surgeries- when ICP won’t go down
Transsphenoidal
Skull cap off
Remove the tumor or clot
EVD device catheter
Aspirate clot or abcess
Scope up nose
T/f. Anyone with increase ICP or has had surgery on the brain will prophylactically be put on anti-seizure medications
true
false
Seizure causes
Tumors
Drugs and alcohol
Electrolyte disturbance especially Na
Cerebrovascular disease
CNS infection/High fever
Assessment seizure and headaches
MRI/CT
EEG
Medications changes
Seizure history
Deficit medication knowledge for seizure
Special therapeutic range
Monitor plasma drug levels
Changes/Withdrawal need to happen under monitoring
Risk for suicide/black box
Teratogenic/competes with birth control
Dermatological effects
SJS
Necrolysis
Migraines
Dilation of coronary arteries
temples
Come and go
Tension
Dilation of coronary arteries
temples
Come and go
Cluster
Dilation of coronary arteries
temples
Come and go
Pharmacological interventions for migraine
Antiemetics
Botulinum toxin: botox
Ketoralac: IV NSAID
Diphenhydramine
Dexamethasone
Meningitis Aseptic
anti-seizure/drug-induced
Will probably start you on prophylactic antivirals/antibiotics
bacterial/viral/fungal
Meningitis
Photophobia
Fever: pressure on thalamus
Change in mental status
Neck mobility/Brudzinki sign chin to sternum
Leg extension/kernig sign knee lift
t/f. ICP symptoms will appear in meningitis
true
false
Meningitis
Risk for ineffective tissue perfusion
Risk for increased ICP
Risk for bleeding
Interventions for meningitis
dark room
Infection precaution
Neurochecks
Temp control risk for febrile seizure
intubate
brain abscess causes
Intracranial surgery
Head injury
Tongue piercing
Infections
Teeth/gums/tongue
Sinus infection
Lungs
Heart
HSV
Brain Abscess Assessment
Depends on location
Fever
Headache
CT
CBC/
Blood culture
LOTS of antibiotics/
Dexamethasone for inflammation
t/f. can’t do chemo for brain tumors don’t cross blood blood-brain barrier
true
false
interventions for brain tumors
Brachytherapy: beads go internally
Reduces inflammation caused by leaky vessels
Medications to reduce ICP
Mannitol
Hypertonic solution
chemo
positioning
Trigeminal Neuralgia
Carbamazepine
sudden/firey pain
Corticosteroids
Protect corneal injury
Avoid cold
Bells Palsy
Carbamazepine
facial paralysis
Corticosteroids
Protect corneal injury
Avoid cold
