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WorksheetsOpioid Free Anesthesia (OFA) - Multiple Choice Questions
Total questions: 10
Worksheet time: 5mins
Which agent provides analgesia and sympatholysis without respiratory depression and is a key component of OFA?
Ketamine
Dexmedetomidine
Lidocaine
Magnesium sulfate
Ketamine contributes to an opioid-free regimen primarily through which mechanism?
GABA receptor modulation
NMDA receptor antagonism
Dopamine reuptake inhibition
Serotonin receptor blockade
Compared with opioid-based anesthesia, OFA is associated with which outcome?
Higher incidence of postoperative nausea and vomiting (PONV)
Increased postoperative sedation
Reduced respiratory depression and PONV
Longer time to extubation
In OFA, an intraoperative lidocaine infusion primarily acts via which mechanism?
Blocking voltage-gated calcium channels
Blocking fast voltage-gated sodium channels
NMDA antagonism
GABA-A potentiation
Which is a common side effect when using dexmedetomidine in OFA?
Hypertension
Tachycardia
Bradycardia and hypotension
Hyperthermia
One aim of OFA is to prevent opioid-induced hyperalgesia (OIH). Which pathway is primarily implicated in OIH?
GABAergic inhibition
NMDA receptor activation
Nicotinic receptor blockade
Dopaminergic activation
A 65-year-old male undergoing laparoscopic colectomy is planned for OFA. Which intraoperative combination represents a typical regimen?
Dexmedetomidine + ketamine + lidocaine infusion
Midazolam + fentanyl + propofol
Morphine + clonidine + rocuronium
Remifentanil + desflurane + paracetamol
Which monitoring parameter is most critical to ensure adequate hypnosis when performing OFA?
Temperature monitoring
BIS or depth of anesthesia
Capnography
Muscle relaxation (TOF)
During OFA, intraoperative hypertension suggests inadequate analgesia. What is the first step?
Administer a rescue opioid
Increase inhalational agent concentration
Evaluate depth of anesthesia and increase non-opioid analgesic infusion
Give a beta-blocker immediately
What is the ultimate goal of OFA in modern anesthesia practice?
Completely eliminate all opioids forever
Achieve balanced analgesia minimizing opioid-related adverse effects
Replace opioids with ketamine only
Reduce anesthesia cost
