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intro ranolazine, nitrates, CCB

Total questions: 29

Worksheet time: 15mins

Name
Class
Date
1.

all nitrates are simple esters of organic alcohol except for

a)

isosorbide dinitrate

b)

amyl nitrite

c)

isosorbide mononitrate

d)

nitroglycerine( glyceryl trinitrate)

2.

name

a)

isosorbide dinitrate

b)

amyl nitrite

c)

isosorbide mononitrate

d)

nitroglycerine( glyceryl trinitrate)

3.

name drug)

a)

phenylal amines( verapamil)

b)

diltiazem

c)

Dihydropyridines( nifedipine,amlodipine,nicardipine)

4.

name drug)

a)

phenylal amines( verapamil)

b)

diltiazem

c)

Dihydropyridines( nifedipine,amlodipine,nicardipine)

5.

name drug)

a)

phenylal amines( verapamil)

b)

diltiazem

c)

Dihydropyridines( nifedipine,amlodipine,nicardipine)

6.

this drug is extensively metabolized by CYp2D6 & CYP3A4

a)

phenylal amines( verapamil)

b)

diltiazem

c)

Dihydropyridines( nifedipine,amlodipine,nicardipine)

d)

ronalazine( S & R) antiomers

7.

the methyl group undergoes

a)

O-demethylation

b)

O-dealklylation

8.

the amide group undergoes

a)

O-demethylation

b)

O-dealklylation

c)

hydrolysis

9.

the tirtiary N group undergoes

a)

O-demethylation

b)

O-dealklylation

c)

N-dalkylation , N-oxidation

10.

undergoes

a)

O-demethylation

b)

O-dealklylation

c)

N-dalkylation , N-oxidation

d)

hydroxylation

11.

name drug that inhibits COX 1 to give antiplatelts effect

a)

aspirin

b)

clopidogrel

12.

........covalently acetylates serine

a)

the acetyl group

b)

carboxyllic group

13.

.......helps with COx1 binding

a)

the acetyl group

b)

carboxyllic group

14.

name this drug

a)

aspirin

b)

Cilastazol

15.

name the thienopyridine

a)

clopidogrel

b)

Prasugrel

16.

name the thienopyridine

a)

clopidogrel

b)

Prasugrel

17.

name the thienopyridine

a)

clopidogrel

b)

Prasugrel

c)

both

18.

short acting, ATP( weak antagonist of P2y12 and not selective) analogue

a)

Ticagrelor

b)

cangrelor

19.

what is the role of the 2 chlorines ( tetraion PKA similar to ATP)

a)

promote hydrolysis

b)

prevent hydrolysis

20.

more lipophilic allowing oral absorption

a)

Ticagrelor

b)

cangrelor

21.

removal of Phosphate chain made molecule more lipophylic

a)

Ticagrelor

b)

cangrelor

22.

antogonizes competitively ADP

a)

Ticagrelor

b)

cangrelor

23.

postiion 7 of ticagrelor gave

a)

potency and stability

b)

increased affinity and metabolic stability

24.

2 Fluorines of ticagrelor gave

a)

potency and stability

b)

increased affinity and metabolic stability

25.

vorapaxar is a

a)

thrombin receptor antagonist

b)

ADP receptor antagonist

26.

this is a tyrosine analogue

a)

eptifibatide

b)

Tiroban

27.

name

a)

eptifibatide

b)

Tiroban

28.
a)

eptifibatide

b)

Tirofiban

29.
a)

eptifibatide

b)

Tirofiban