WorksheetsAntiviral quiz (23/10/2025)
Total questions: 10
Worksheet time: 5mins
Which statement best describes the difference between anti-HBV and anti-HCV agents?
Both are curative
Anti-HBV agents are suppressive, while anti-HCV agents can achieve viral eradication
Both are suppressive
Anti-HCV agents are suppressive, while anti-HBV agents can achieve viral eradication
Which of the following best explains why bismonomethoxypolyethylene glycol is covalently attached to interferon-α-2a or -α-2b in "pegylated" formulations?
To increase the size of the molecule so to delay absorption
To enhance the drug's solubility in water.
To reduce the drug's immunogenicity.
To increase the drug's toxicity.
What is the main reason Boceprevir and Telaprevir are discontinued in HCV treatment?
They are too expensive
More potent and better-tolerated regimens are available
They cause severe side effects
They are not effective against HCV
According to the WHO's recommendation, which combination is used as the standard hepatitis C treatment in public hospitals in Malaysia?
Sofosbuvir and ribavirin
Sofosbuvir and daclatasvir
Boceprevir and telaprevir
Ribavirin and interferon
Strategically, why is the use of direct-acting antiviral (DAA)-based regimens significant in the treatment of HCV?
They are less expensive than older treatments
They offer higher cure rates and better tolerability compared to previous regimens
They require no medical supervision
They are only effective in early-stage HCV
Ribavirin triphosphate contributes to the inhibition of a wide range of DNA and RNA viruses, including HCV, primarily by:
Directly destroying viral particles
Inhibiting the replication of viral RNA and DNA through interference with RNA-dependent polymerase
Enhancing the immune system’s response
Blocking viral entry into host cells
Acyclovir triphosphate inhibits viral DNA synthesis by which two mechanisms?
Competition with deoxy-GTP for viral DNA polymerase and chain termination after incorporation into viral DNA
Inhibition of host cell replication and blocking cell membrane synthesis
Activation of immune cells and destruction of viral proteins
Inhibition of RNA synthesis and prevention of viral entry
Why does acyclo-GMP cause chain termination during DNA synthesis?
It lacks a 3'-hydroxyl group
It is unable to bind to DNA polymerase
It contains an extra phosphate group
It is rapidly degraded in the cytoplasm
Which enzyme is essential for the influenza virus life cycle and is targeted by drugs such as oseltamivir and zanamivir?
Neuraminidase
Reverse transcriptase
DNA polymerase
Protease
Which of the following is a common adverse effect of oseltamivir?
Nausea
Headache
Rash
Insomnia
