Worksheets527 Side effects
Total questions: 10
Worksheet time: 5mins
The main reason chemotherapy causes side effects in patients is because it:
Only targets malignant cells
Damages both tumour and rapidly dividing normal cells
Suppresses immune cells selectively
Induces permanent genetic mutations in healthy tissues
Myelosuppression due to chemotherapy most often affects which group of cells first?
Platelets
Erythrocytes
Granulocytes
Lymphocytes
The onset of neutropenia usually occurs around which time frame post-chemotherapy?
1–2 days
3–7 days
10–14 days
6–8 weeks
Which of the following is the most suitable management for a patient presenting with neutropenic sepsis?
Increase oral hydration only
Outpatient management with oral antibiotics
Hospital admission for IV broad-spectrum antibiotics
Delay further chemotherapy without antibiotics
Platelet transfusions are likely required when patients exhibit signs such as:
Fever and chills
Petechial rash and prolonged bleeding from minor cuts
Alopecia and mucositis
Muscle cramps and fatigue
Chemotherapy-induced nausea and vomiting occur mainly due to:
Inhibition of dopamine receptors in the CNS
Stimulation of 5-HT3 receptors in the GI tract and vagus nerve
Increased acetylcholine activity in the brainstem
Hypersensitivity reactions to cytotoxic agents
Which of the following antiemetic regimens is recommended for highly emetogenic chemotherapy?
Metoclopramide alone
Combination of 5-HT3 receptor antagonist, dexamethasone, and NK-1 antagonist
Ondansetron monotherapy
Lorazepam and diphenhydramine
A cancer patient reports tingling sensations, numbness, and difficulty with fine motor tasks. Which drug class is most likely responsible?
Platinum compounds and taxanes
Anthracyclines
Antimetabolites
Alkylating agents
Which of the following measures helps prevent palmar-plantar syndrome associated with paclitaxel or doxorubicin?
Daily topical retinoids
Ice packs under hands and feet during infusion
Continuous heat application to extremities
Steroid mouthwash
Extravasation of doxorubicin should be managed initially with:
Warm compress and hyaluronidase
Cold compress and dexrazoxane administration
Cold compress only
Hot compress and topical dimethyl sulfoxide
