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WorksheetsVancomycin TDM
Total questions: 7
Worksheet time: 4mins
What is the usual MIC range for vancomycin against Staphylococcus aureus?
0.25–0.5 mg/L
1–2 mg/L
4–8 mg/L
>8 mg/L
Which statement correctly describes vancomycin susceptibility for Staphylococcus aureus?
Vancomycin-intermediate S. aureus (VISA) has MIC < 2 µg/mL
Vancomycin-resistant S. aureus (VRSA) has MIC ≥ 16 µg/mL
VISA strains have MIC ≥ 16 µg/mL
VRSA strains have MIC between 4–8 µg/mL
Which of the following best describes Mean Arterial Pressure (MAP)?
The difference between systolic and diastolic blood pressure
The average arterial pressure during one cardiac cycle; values < 60 mmHg indicate inadequate organ perfusion
The maximum pressure exerted during ventricular contraction
The minimum pressure in arteries during ventricular relaxation
Which statement correctly differentiates time-dependent from concentration-dependent antibiotics?
Time-dependent antibiotics kill bacteria faster and more effectively when the peak concentration (Cmax) is much higher than the MIC.
Time-dependent antibiotics rely on how long the concentration stays above the MIC, while increasing the dose above MIC doesn’t increase killing speed.
Concentration-dependent antibiotics require continuous infusion to maintain efficacy.
Both types achieve the same killing effect regardless of concentration or time.
When should the maintenance dose of vancomycin be started after a loading dose in patients with normal renal function?
Immediately after loading dose
6 hours after loading dose
At the next scheduled dosing interval (e.g., 12 hours later)
24 hours later
Which is a key difference between conventional and continuous vancomycin infusion?
Continuous infusion maintains stable serum concentrations
Conventional infusion uses a lower total daily dose
Continuous infusion increases peak-trough fluctuation
Conventional infusion requires no monitoring
Which of the following correctly describes the relationship between Cpost, Cmax, Cpre, and Cmin in vancomycin monitoring?
Cpost is the highest true plasma concentration, always greater than Cmax.
Cmax is the true peak concentration estimated from Cpost, while Cpre (measured) is approximately equal to the calculated Cmin.
Cmin is obtained 1–2 hours after the end of infusion to assess peak distribution.
Cpre is the predicted value derived from pharmacokinetic equations rather than direct measurement.
