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WorksheetsPK Exam 3
Total questions: 10
Worksheet time: 5mins
Which statement correctly describes the role of SLCO1B1 in statin therapy?
SLCO1B1 activates statins in the liver
SLCO1B1 increases intestinal absorption of statins
SLCO1B1 facilitates hepatic uptake of statins
SLCO1B1 decreases systemic statin exposure
Increased copy numbers of the CYP2D6 gene (e.g., *1x2, 2x2) can result in an ultrarapid metabolizer (UM) phenotype. For which of the following medications would this genetic variation most likely lead to increased drug activation and risk of toxicity?
Codeine
Clopidogrel
Omeprazole
Warfarin
Mr. R is a 50-year-old man (height 180 cm, actual body weight 120 kg, SCr 1.0 mg/dL).
You’re asked to estimate his CrCl using the Cockcroft–Gault equation for a renally eliminated antibiotic.
Which weight should be used?
Actual body weight
Ideal body weight
Adjusted body weight
Lean body mass
Which statement best describes how activity scores should be interpreted in clinical context?
They represent fixed values that predict response regardless of environment or co-medications.
They must always be interpreted alongside other clinical and extrinsic factors
They are more reliable than phenotype or clinical data when making dosing decisions
They are used only for pharmacodynamic genes, not pharmacokinetic ones
A patient who abuses amphetamines reports using baking soda to “make the high last longer.”
What is the pharmacokinetic effect of this practice?
Urine alkalinization decreases ionization of amphetamine, increasing reabsorption and prolonging effect
Urine alkalinization increases ionization of amphetamine, reducing reabsorption.
Urine alkalinization has no effect on basic drugs.
Urine alkalinization increases tubular secretion of amphetamine.
A patient with end-stage kidney disease is receiving gentamicin (an aminoglycoside). Compared to a healthy person, which of the following is most likely true?
Gentamicin’s Vd is decreased because of protein binding changes
Gentamicin’s Vd is increased due to expansion of extracellular fluid volume
Gentamicin’s Vd is unchanged because it’s lipophilic
Gentamicin’s Vd decreases due to loss of tissue binding
According to the Dettli principle, which of the following statements is true?
CLNR increases with declining kidney function
ke increases linearly with CLcr
ke decreases linearly with CLcr, while CLNR remains constant
Drug metabolism is unaffected by disease
Which CNS drug exhibits nonlinear pharmacokinetics due to autoinduction of its metabolism?
Lithium
Carbamazepine
Sertraline
Clozapine
A 67-year-old man with stage 3 CKD presents with confusion and tremor. His lithium level is 1.8 mEq/L.
Which factor could have contributed to this finding?
Recent caffeine increase
Started hydrochlorothiazide for blood pressure
Switched to a high-sodium diet
Missed multiple lithium doses
SELECT ALL THAT APPLY: Which of the following mechanisms can lead to nonlinear pharmacokinetics?
Saturation of metabolizing enzymes
Autoinduction or autoinhibition of drug metabolism
First-order elimination
Limited aqueous solubility
