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WorksheetsInfections and Disease II
Total questions: 52
Worksheet time: 28mins
constantly present at a low level in a given geographical area
e.g. common cold
hepatitis A
endemic disease
sporadic
epidemic
pandemic
FEW scattered cases occur within an area or population
e.g. meningitis
meningitis fasciitis
endemic disease
sporadic
epidemic
pandemic
greater than normal number of cases in an area within a given period
e.g. influenza
SARS CoV 1
endemic disease
sporadic
epidemic
pandemic
what type of curve is used to track diseases?
Epi curve
Health impact curve
the epi curve can tell us about:
incubation period
type of exposure & spread of disease
incidence & prevalence rate
disease progression within an area
a more contained epidemic
e.g. rubella (London, ON)
Legionnaire's (Toronto)
endemic disease
sporadic
epidemic
pandemic
outbreak
worldwide epidemic of a specific disease
e.g. AIDS
Swine Flue
SARS CoV 2
endemic disease
sporadic
epidemic
pandemic
outbreak
as per WHO, ____ is a community-level spread in multiple countries in 2 or more regions
endemic disease
sporadic
epidemic
pandemic
outbreak
predominantly animal infections
few human infections
Phase 1-3 of
Pandemic
Phase 4 of
Pandemic
Phase 5-6 of Pandemic
Post Peak
Post pandemic
sustained human to human transmission
Phase 1-3 of
Pandemic
Phase 4 of
Pandemic
Phase 5-6 of Pandemic
Post Peak
Post pandemic
widespread human infection
Phase 1-3 of
Pandemic
Phase 4 of
Pandemic
Phase 5-6 of Pandemic
Post Peak
Post pandemic
possibility of recurrent events
Phase 1-3 of
Pandemic
Phase 4 of
Pandemic
Phase 5-6 of Pandemic
Post Peak
Post pandemic
disease activity at seasonal levels
Phase 1-3 of
Pandemic
Phase 4 of
Pandemic
Phase 5-6 of Pandemic
Post Peak
Post pandemic
type of disease
can be spread from person to person
Communicable
Contagious
Noncommunicable
type of disease such as
HIV
Chlamydia
Cholera
MRSA
Communicable
Contagious
Noncommunicable
type of disease
very easily spread from person to person
CONTACT usually not required
Communicable
Contagious
Noncommunicable
type of disease such as
Common cold
Chicken pox
Measles
Rubella
Communicable
Contagious
Noncommunicable
an example of infectious disease is
TETANUS
Communicable
Contagious
Noncommunicable
rapid onset,
has climax rapid recovery
e.g. flu, measles
Acute Infection
Chronic Infection
Primary Infection
Secondary Infection
slow onset,
longer duration
no climax
e.g. TB, Hep A
Acute Infection
Chronic Infection
Primary Infection
Secondary Infection
first or original illness
Acute Infection
Chronic Infection
Primary Infection
Secondary Infection
another infection in weakened individual
can be due to medical intervention
Acute Infection
Chronic Infection
Primary Infection
Secondary Infection
infection confined to a single area in body
e.g. staph infection, step throat
local infection
systemic infection
infection enters blood stream &/ or spreads into tissues
e.g. septicemia, viremia, septic shock, measles, AIDS
local infection
systemic infection
what are chances of acquiring nosocomial infections in canada?
5%
10%
8%
In Common Hospital-Acquired Diseases
how many % accounts for Urinary Tract infections?
40%
19%
6%
15%
8%
In Common Hospital-Acquired Diseases
how many % accounts for Surgical sites infections?
40%
19%
6%
15%
8%
In Common Hospital-Acquired Diseases
how many % accounts for respiratory infections?
40%
19%
6%
15%
8%
In Common Hospital-Acquired Diseases
how many % accounts for septicemia infections?
40%
19%
6%
15%
8%
factors influencing nosocomial infections
presence of microbes in hospital environment
immunocompromised patients
transmission of pathogens between staff, patients, & among patients
health worker induced infection
iatrogenic infection
exogenous
infection
idiopathic
infection
endogenous
infection
what are the portal of entry of pathogens in the body?
bloodstream and lymphatic system.
eyes, ears, mouth and nose
Skin lesions, urethra, anus
nails and hair follicles.
what are the usual portal of exit of pathogens in the body?
Respiratory secretions, urine, blood, and saliva.
Blood, feces, insect bite, open lesion.
factors contributing to disease
Infectious Dose
weather conditions
Virulence factors
Susceptibility of host
Host genetic pre-disposition
virulence is determined by
the ability of microbe to penetrate
invasiveness
toxicity
virulence is determined by
the ability of microbe to generate harmful toxins
invasiveness
toxicity
Virulence Factors
cell wall
toxins
extracellular enzymes
adhesins
potency
found on pili, cell wall, outer membrane, capsid, spikes
can induce phagocytosis or endocytosis
(a)
secreted by pathogen:
clots plasma creating their own plasma wall
e.g. Staphylococcus Aureus
Leukocidins
Hyaluronidase
Kinases
Hemolysins
secreted by pathogen:
enzyme that dissolve blood clots
e.g. streptokinase
Leukocidins
Hyaluronidase
Kinases
Hemolysins
enzymes injected to cases of stroke, heart attack, deep vein thrombosis
Leukocidins
Hyaluronidase
Kinases
Hemolysins
enzyme that dissolves tissue glue
allowing microbes to spread rapidly through tissue
e.g. gas gangrene, Strep
Leukocidins
Hyaluronidase
Kinases
Hemolysins
destroy WBCs
induce release of lysozomal enzymes (kills WBC)
e.g. staph & strep species
Leukocidins
Hyaluronidase
Kinases
Hemolysins
enzymes that destroy RBC
Leukocidins
Hyaluronidase
Kinases
Hemolysins
what is usually used to identify bacteria?
extracellular enzymes
pathogenicity islands
outer membrane
genes that code for pathogenic factors are clustered into
transferred by "horizontal gene transfer"
extracellular enzymes
pathogenicity islands
outer membrane
mode of action in pathogen infection:
tissue specific
destroy tissue or alter chemical production or release
exotoxins
endotoxins
mode of action in pathogen infection:
most deadly chemicals
exotoxins
endotoxins
mode of action in pathogen infection:
systemic inflammation
induce blood clots and activate complement system
exotoxins
endotoxins
mode of action in pathogen infection:
can lead to SHOCK if severe
tissue swelling, drop in blood pressure
antibiotic induced
exotoxins
endotoxins
involves GRAM+ bacteria
examples include botulism, diptheria, tetanus
exotoxins
endotoxins
involves GRAM- bacteria
examples Dysentery, Meningitis, Typhoid Fever, Cholera
exotoxins
endotoxins
