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Pharmacology and Chemotherapy Regimens Worksheet

Total questions: 38

Worksheet time: 22mins

Name
Class
Date
1.

WOTF does NOT produce its antifungal infect by inhibiting cell wall synthesis?

a)

Pneumocandins

b)

Polyoxin D

c)

Aculeacins

d)

Undecylenic acid (Tineacide)

e)

Nikomycin Z

2.

WOTF is an MTX analog that is most likely to be used for the treatment of liver cancer?

a)

Edatrexate

b)

Phototrexate

c)

Nolatrexed (Thymitaq)

d)

Pemetrexed (Amimta, Pemfexy)

e)

Pralatrexate (Folotyn)

3.

WOTF combination regimens is NOT correctly matched with the type of cancer that it is used to treat?

a)

CYVADIC - Osteosarcoma

b)

OFF - Pancreatic Cancer

c)

ELF - Stomach (gastric) Cancer

d)

MBC - Colorectal Cancer

e)

MACOA - Burkitt's Lymphoma

4.

WOTF is classified as a mold?

a)

Candida auris

b)

Trichosporon beigelii

c)

Turuolopsis grablata (Candida grablata)

d)

Rhizomucor pusillus

e)

Cryptococcus neoformans

5.

WOTF produces its antifungal effect by inhibiting protein synthesis in the fungus?

a)

Omoconazole

b)

Kerydin (Tavaborole)

c)

Griseofulvin (Grifulvin V, Gris-PEG)

d)

Haloprogren (Halotex)

e)

Ciclopirox (Penlac lacquer)

6.

How does Kerydin (Tavaborole) inhibit protein synthesis?

a)

Inhibits Leucyl-tRNA (Leu-tRNA) Synthetase

b)

Inhibits Peptidyl Transferase

c)

Blocks Ribosomal RNA Synthesis

d)

Inhibits Aminoacyl-tRNA Synthetase for Methionine

7.

Methotrexate has been shown to be beneficial/useful in WOTF conditions? SATA

a)

Psoriasis

b)

CTCL (Cutaneous T-Cell Lymphoma) - used for Peripheral T-Cell Lymphoma

c)

Rheumatoid arthritis

d)

Procuring Abortion

e)

PCP (Pneumocystis Pneumonia)

8.

What is the maintenance dose for Caspofungin (Cancidas)?

a)

50 mg IV QD

b)

70 mg IV QD

c)

25 mg IV QD

d)

100 mg IV QD

9.

What is the maintenance dose for Micafungin (Mycamine)?

a)

150 mg IV QD

b)

50 mg IV QD

c)

100 mg IV QD

d)

200 mg IV QD

10.

What is the maintenance dose for Rezafungin (Rezzayo)?

a)

200 mg IV weekly

b)

400 mg IV daily

c)

100 mg IV monthly

d)

50 mg IV weekly

11.

WOTF is an Imidazole antifungal drug that is used primarily for vaginal candidiasis?

a)

Voriconazole (VFEND)

b)

Sulconazole (Exelderm)

c)

Luliconazole (Luzu)

d)

Terconazole (Terazol)

e)

Butaconazole- (Gynazole, Femstat)

12.

WOTF is a Triazole antifungal that is used primarily for the management of onychomycosis?

a)

Efinaconazole (Jublia) - Triazole

b)

Econazole (Ecoza, Spectazole) - Imidazole

c)

Miconazole (Monistat) - Imidazole

d)

Sertaconazole (Ertaczo) - Imidazole

13.

A patient is extremely allergic to Cisplatin (Platinol), and the patient has ovarian cancer. WOTF should NOT be used to treat the patient's ovarian cancer? SATA

a)

Olaparib

b)

CAP

c)

CISCA

d)

Irinotecan

e)

CHAD

14.

WOTF is absent from the EMA-CO combination therapy?

a)

Dactinomycin (Actinomycin-D)

b)

Etoposide (VePesid, Toposar, and Etopophos)

c)

Methotrexate (Amethopterin, Trexall)

d)

Cyclophosphamide (Cytoxan)

e)

Mitomycin (Mutamycin)

15.

WOTF is absent in HYPER CVAD- A?

a)

Adriamycin (Doxorubicin)

b)

Cyclophosphamide (Cytoxan)

c)

Cytarabine (Ara-C)

d)

Vincristine (Oncovin)

e)

Dactinomycin (Actinomycin-D)

16.

WOTF statements about HyperCVAD-B is FALSE?

a)

It is given for 21 days in each cycle

b)

It is employed in managing CLL (Chronic Lymphocytic Leukemia) - it is used for Acute Lymphocytic Leukemia (ALL)

c)

It contains Methotrexate

d)

It consists of Ara-C (Cytarabine)

e)

You start administering it (HyperCVAD-B) after giving HyperCVAD-A for 21 days

17.

Fluconazole will increase/elevate the AUC of WOTF? SATA

a)

Sulfonylureas

b)

Omeprazole (Prilosec)

c)

Plavix (Clopidogrel)

d)

Dilantin (Phenytoin)

e)

Antidepressants

18.

What is the ratio of DMPC (distearoyl phosphatidylcholine) to DMPG (dimyristoyl phosphatidylglycerol) in Abelcet (Amphotericin B lipid complex, ABLC)?

(a)  

19.

What is the terminal half-life of amphotericin B (Fungizone - Rep Agent)?

a)

15 days

b)

24 hours - Initial half-life, also half-life is Biphasic

20.

How can Amphotericin B be administered?

a)

Intravitreally

b)

Subconjunctivally

c)

Intra-articularly (IA)

d)

Others: i. IV (Intravenously) ii. IT (Intrathecally) iii. IM (Intramuscularly) iv. Inhalation (Pulmonary System) v. IVT (Intraventricularly) vi. Topically

21.

Which of the following statements about Voriconazole (Vfend) is true?

a)

It is effective against the asexual form of Pseudallescheria (Pseudallescheria boydii) - (a Scedosporium)

b)

It is a strong inhibitor of CYP3A4

c)

It is metabolized/biotransformed by (Substrate for) CYP2C9 and 2C19

d)

6mg/kg IV Q12H x2 doses is its initial dose when used for aspergillosis - 4mg/kg IV Q12H is the maintenance dose

e)

It can impair night vision (Blurry vision, photophobia), and it can cause chromatopsia (affects perception of color)

22.

Itraconazole (Sporanox) is effective in the treatment of which of the following conditions?

a)

amoebic meningoencephalitis caused by naegleria fowleri

b)

Leishmaniasis

c)

Pseudallescheriasis caused by Pseudallescheria boydii infection

d)

Sporotrichosis

e)

Protothecosis (Algae infection) - AmB indication

23.

Which of the following is a long-term adverse effect of Amphotericin B?

a)

Evidence of bleeding: hemoptysis, epistaxis, melena

b)

Elevation of Blood Urea Nitrogen (BUN)

c)

Normocytic normochromic anemia

d)

Hypomagnesemia, Hypokalemia, Hypocalcemia

e)

Elevated Serum Creatinine

24.

WOTF is used to treat Colorectal Cancer? SATA

a)

Dostarlimab (Jemperli) - regarded as a cure for colorectal cancer and ovarian cancer

b)

FOLFIRI + Cetuximab (Erbitux)

c)

CAPOX

d)

CMV

e)

XELOX

25.

WOTF combination regimens contains a Human Epidermal Growth Factor Receptor 2 (HER2) Inhibitor? SATA.

a)

NFL

b)

TCP

c)

ACTH

d)

ACD

e)

TDP

26.

How would you counsel a patient who is on Terbinafine (Lamisil)?

a)

No alcohol → increase hepatotoxicity

b)

It can cause neutropenia; a CBC is advisable.

c)

LFT is advisable for long-term use.

d)

Do not take with acidic food; absorption can be decreased by any acidic foods, including fruits.

e)

Terbinafine can produce dysgeusia (taste disturbance), which is not reversed or diminished by food.

27.

What does Terbinafine (Lamisil) do to SSRIs? SATA

a)

inhibits CYP2D6, decreasing the metabolism of SSRIs

b)

induces CYP2D6, increasing the metabolism of SSRIs

c)

increases risk of SSRI toxicity

d)

Directly enhances serotonin reuptake, decreasing SSRI efficacy

28.

What does Terbinafine (Lamisil) do to caffeine?

a)

enhances the rate of caffeine metabolism

b)

prevents caffeine from binding to receptors

c)

increases the duration of action of caffeine

29.

What does Terbinafine (Lamisil) do to TCAs?

a)

Decrease metabolism of the TCA

b)

Increases concentration of TCA

c)

Produces TCA toxicity

30.

WOTF statements about Brexafemme (ibrexafungerp) is true?

a)

It is a triterpenoid antifungal agent

b)

It is administered on a BID basis

c)

It is an inhibitor of cell membrane synthesis

d)

It is used to treat VVC

e)

It is employed in treating candidal infections that are resistant to echinocandins and triazole antifungals.

31.

WOTF is involved in the MOA of Methotrexate in neoplasms? SATA

a)

Inhibition of DHFR (dihydrofolate reductase)

b)

Alkylation of nucleic acids

c)

Inhibition of thymidylate synthase

d)

Inhibition of aldehyde oxidase

e)

Inhibition of the de novo synthesis of nucleic acids

32.

What is the TLT (Therapy Limiting Toxicity) of Cyclophosphamide (Cytoxan)?

(a)  

33.

How can you prevent/manage Hemorrhagic Cystitis of Cytoxan? Coadminister with?

a)

Hydration (NS)

b)

Mesna (Uromitexan, Mesnex)

c)

Acetylcysteine (Mucomyst)

34.

WOTF is contained in the M2 Regimen that you use to treat Multiple Myeloma?

a)

Melphalan (Alkeran)

b)

Cyclophosphamide (Cytoxan)

c)

Prednisone

d)

Vincristine (Oncovin)

e)

BCNU (Carmustine)

35.

What is the other name for BCNU?

(a)  

36.

What is the other name for CCNU?

(a)  

37.

WOTF is an indication for Soliris (Eculizumab)?

a)

Myasthenia gravis

b)

PNH (Paroxysmal Nocturnal Hemoglobinuria) - ↑ of hemoglobin in urine

c)

Acute cerebellar syndrome (ACS)

d)

HUS (Hemolytic Uremic Syndrome)

e)

Esophageal pharyngitis - inflammation of the esophagus

38.

What drugs produce HUS (Hemolytic Uremic Syndrome)?

a)

flucytosine

b)

5-FU

c)

Soliris

d)

5- FC

e)

Fluorouracil