WorksheetsCC-P20
Total questions: 134
Worksheet time: 1hrs 7mins
Name
Class
Date
1.
Most common cause of hypercalcemia
a)
Primary hyperparathyroidism
b)
Secondary hyperparathyroidism
c)
Tertiary hyperparathyroidism
2.
Due to the presence of a functioning parathyroid adenoma
a)
Primary hyperparathyroidism
b)
Secondary hyperparathyroidism
c)
Tertiary hyperparathyroidism
3.
Develops in response to decrease serum calcium
a)
Primary hyperparathyroidism
b)
Secondary hyperparathyroidism
c)
Tertiary hyperparathyroidism
4.
Causes: Vitamin D deficiency and chronic renal failure
a)
Primary hyperparathyroidism
b)
Secondary hyperparathyroidism
c)
Tertiary hyperparathyroidism
5.
Occurs with secondary hyperparathyroidism
a)
Primary hyperparathyroidism
b)
Secondary hyperparathyroidism
c)
Tertiary hyperparathyroidism
6.
Patient develops severe bone disease
a)
Primary hyperparathyroidism
b)
Secondary hyperparathyroidism
c)
Tertiary hyperparathyroidism
7.
Due to accidental injury to the parathyroid gland during surgery
a)
Hypoparathyroidism
b)
Pseudohypoparathyroidism
8.
Albright hereditary osteodystrophy
a)
Hypoparathyroidism
b)
Pseudohypoparathyroidism
9.
Develops due to genetic mutation resulting to ineffective PTH action in the presence of a functioning parathyroid gland
a)
Hypoparathyroidism
b)
Pseudohypoparathyroidism
10.
single polyclonal antibody assay
a)
First Generation Assay
b)
Second Generation Assay
c)
Third Generation Assay
11.
intact PTH assay
a)
First Generation Assay
b)
Second Generation Assay
c)
Third Generation Assay
12.
whole PTH biointact PTH assay
a)
First Generation Assay
b)
Second Generation Assay
c)
Third Generation Assay
13.
yellow
a)
Adrenal Cortex
b)
Adrenal medulla
14.
dark mahogany
a)
Adrenal Cortex
b)
Adrenal medulla
15.
Composed primarily of chromaffin cells that secrete catecholamines
a)
Adrenal Cortex
b)
Adrenal medulla
16.
L-tyrosine is the precursor of the catecholamines
a)
Adrenal Cortex
b)
Adrenal medulla
17.
inner region
a)
Adrenal Cortex
b)
Adrenal medulla
18.
outer region
a)
Adrenal Cortex
b)
Adrenal medulla
19.
Major site of steroid hormone production
a)
Adrenal Cortex
b)
Adrenal medulla
20.
Secretes cortisol, aldosterone, and weak androgens
a)
Adrenal Cortex
b)
Adrenal medulla
21.
Cortisol source
a)
Zona fasciculata
b)
Zona glomerulosa
c)
Zona reticularis
22.
Aldosterone source
a)
Zona fasciculata
b)
Zona glomerulosa
c)
Zona reticularis
23.
Weak androgens / Adrenal androgens source
a)
Zona fasciculata
b)
Zona glomerulosa
c)
Zona reticularis
24.
Only adrenal hormone that inhibits the secretion of ACTH
a)
Cortisol
b)
Aldosterone
c)
Weak androgens
25.
Secretion is diurnal and associated with a person’s sleep-wake cycle with high levels in the morning (8 AM to 10 AM) and lowest at night (10 AM to 12 MN)
a)
Cortisol
b)
Aldosterone
c)
Weak androgens
26.
Most potent mineralocorticoid (electro-regulating hormone)
a)
Cortisol
b)
Aldosterone
c)
Weak androgens
27.
Steroid hormone that helps regulate water, electrolytes and blood pressure
a)
Cortisol
b)
Aldosterone
c)
Weak androgens
28.
By-products of cortisol synthesis that are regulated by ACTH
a)
Cortisol
b)
Aldosterone
c)
Weak androgens
29.
Serve as precursors for the production of more potent androgens and estrogens in tissues
a)
Cortisol
b)
Aldosterone
c)
Weak androgens
30.
Colorimetry test: Porter-Silber method
a)
17-hydroxycorticosteroid
b)
17-ketogenic steroids
31.
(+) yellow
a)
17-hydroxycorticosteroid
b)
17-ketogenic steroids
32.
Colorimetry test: Zimmerman reaction
a)
17-hydroxycorticosteroid
b)
17-ketogenic steroids
33.
(+) reddish-purple
a)
17-hydroxycorticosteroid
b)
17-ketogenic steroids
34.
Cushing’s Syndrome
a)
Hypercortisolism
b)
Hypocortisolism
35.
Primary Hypoadrenalism
a)
Hypercortisolism
b)
Hypocortisolism
36.
Primary Adrenal Insufficiency
a)
Hypercortisolism
b)
Hypocortisolism
37.
Tertiary Adrenal Insufficiency
a)
Hypercortisolism
b)
Hypocortisolism
38.
Screening test for hypocortisolism (Cushing's syndrome)
a)
24-hour urinary free cortisol
b)
Overnight dexamethasone suppression
c)
Midnight salivary cortisol
d)
Low-dose dexamethasone suppression
e)
Midnight plasma cortisol
39.
Confirmatory test for hypocortisolism (Cushing's syndrome)
a)
24-hour urinary free cortisol
b)
Overnight dexamethasone suppression
c)
Midnight salivary cortisol
d)
Low-dose dexamethasone suppression
e)
Midnight plasma cortisol
40.
Characterized by 90% destruction of the adrenal cortex with low or deficient cortisol in the presence of excess ACTH release
a)
Cushing’s Syndrome
b)
Primary Hypoadrenalism / Primary Adrenal Insufficiency
c)
Secondary Hypoadrenalism / Secondary Adrenal Insufficiency
d)
Tertiary Hypoadrenalism / Tertiary Adrenal Insufficiency
41.
Example: Addison’s disease – mostly caused by autoimmune destruction of adrenal cortex
a)
Cushing’s Syndrome
b)
Primary Hypoadrenalism / Primary Adrenal Insufficiency
c)
Secondary Hypoadrenalism / Secondary Adrenal Insufficiency
d)
Tertiary Hypoadrenalism / Tertiary Adrenal Insufficiency
42.
Due to hypothalamic-pituitary insufficiency with loss of ACTH
a)
Cushing’s Syndrome
b)
Primary Hypoadrenalism / Primary Adrenal Insufficiency
c)
Secondary Hypoadrenalism / Secondary Adrenal Insufficiency
d)
Tertiary Hypoadrenalism / Tertiary Adrenal Insufficiency
43.
Related to defective hypothalamic release of CRH with decreased ACTH
a)
Cushing’s Syndrome
b)
Primary Hypoadrenalism / Primary Adrenal Insufficiency
c)
Secondary Hypoadrenalism / Secondary Adrenal Insufficiency
d)
Tertiary Hypoadrenalism / Tertiary Adrenal Insufficiency
44.
Group of clinical and metabolic disorders characterized by adrenocortical hyperfunction
a)
Cushing’s Syndrome
b)
Primary Hypoadrenalism / Primary Adrenal Insufficiency
c)
Secondary Hypoadrenalism / Secondary Adrenal Insufficiency
d)
Tertiary Hypoadrenalism / Tertiary Adrenal Insufficiency
45.
Also due to chronic excessive production of cortisol
a)
Cushing’s Syndrome
b)
Primary Hypoadrenalism / Primary Adrenal Insufficiency
c)
Secondary Hypoadrenalism / Secondary Adrenal Insufficiency
d)
Tertiary Hypoadrenalism / Tertiary Adrenal Insufficiency
46.
Caused primarily by excessive exposure to corticosteroids
a)
Cushing’s Syndrome
b)
Primary Hypoadrenalism / Primary Adrenal Insufficiency
c)
Secondary Hypoadrenalism / Secondary Adrenal Insufficiency
d)
Tertiary Hypoadrenalism / Tertiary Adrenal Insufficiency
47.
Secondary Adrenal Insufficiency
a)
Hypercortisolism
b)
Hypocortisolism
48.
• Measures the response of adrenal cortex to parenteral ACTH
a)
ACTH / Cosyntropin Stimulation Test
b)
Insulin Tolerance Test
c)
Overnight Metyrapone Test
49.
Gold standard test in the assessment of hypothalamus-pituitary axis
a)
ACTH / Cosyntropin Stimulation Test
b)
Insulin Tolerance Test
c)
Overnight Metyrapone Test
50.
Most reliable test to diagnose secondary adrenal insufficiency
a)
ACTH / Cosyntropin Stimulation Test
b)
Insulin Tolerance Test
c)
Overnight Metyrapone Test
51.
Measures the ability of the pituitary gland to respond to declining levels of circulating cortisol determines the functionality of HPA axis
a)
ACTH / Cosyntropin Stimulation Test
b)
Insulin Tolerance Test
c)
Overnight Metyrapone Test
52.
Helps in diagnosis of primary adrenal insufficiency
a)
ACTH / Cosyntropin Stimulation Test
b)
Insulin Tolerance Test
c)
Overnight Metyrapone Test
53.
Most common form of CAH
a)
21-hydroxylase deficiency
b)
11-β-hydroxylase deficiency
c)
3-β-hydroxysteroid dehydrogenase-isomerase deficiency
d)
17-hydroxylase deficiency
e)
Congenital lipoid adrenal hyperplasia
54.
Second most common form of CAH
a)
21-hydroxylase deficiency
b)
11-β-hydroxylase deficiency
c)
3-β-hydroxysteroid dehydrogenase-isomerase deficiency
d)
17-hydroxylase deficiency
e)
Congenital lipoid adrenal hyperplasia
55.
Elevated ratio of 17α-hydroxypregnenolone to 17α-hydroxyprogesterone and increased ratio of DHEA to androstenedione
a)
21-hydroxylase deficiency
b)
11-β-hydroxylase deficiency
c)
3-β-hydroxysteroid dehydrogenase-isomerase deficiency
d)
17-hydroxylase deficiency
e)
Congenital lipoid adrenal hyperplasia
56.
Inability to convert 17-hydroxypregnenolone to DHEA and 17α hydroxyprogesterone
a)
21-hydroxylase deficiency
b)
11-β-hydroxylase deficiency
c)
3-β-hydroxysteroid dehydrogenase-isomerase deficiency
d)
17-hydroxylase deficiency
e)
Congenital lipoid adrenal hyperplasia
57.
Most severe form of CAH
a)
21-hydroxylase deficiency
b)
11-β-hydroxylase deficiency
c)
3-β-hydroxysteroid dehydrogenase-isomerase deficiency
d)
17-hydroxylase deficiency
e)
Congenital lipoid adrenal hyperplasia
58.
Which test for CAH is the most preferred and definitive method?
a)
Genotyping cells from chorionic villous sampling
b)
17-hydroxyprogesterone (17-OHP) measurement in amniotic fluid
c)
ACTH Stimulation Test
59.
Conn’s Syndrome
a)
Primary Hyperaldosteronism
b)
Secondary Hyperaldosteronism
c)
Liddle’s Syndrome
60.
Aldosterone-secreting adrenal adenoma
a)
Primary Hyperaldosteronism
b)
Secondary Hyperaldosteronism
c)
Liddle’s Syndrome
61.
Associated with elevated plasma aldosterone and low plasma renin
a)
Primary Hyperaldosteronism
b)
Secondary Hyperaldosteronism
c)
Liddle’s Syndrome
62.
Occurs as a result of excessive production of renin or overactivity of RAAs
a)
Primary Hyperaldosteronism
b)
Secondary Hyperaldosteronism
c)
Liddle’s Syndrome
63.
Pseudohyperaldosteronism
a)
Primary Hyperaldosteronism
b)
Secondary Hyperaldosteronism
c)
Liddle’s Syndrome
64.
Congenital disorder characterized by increased epithelial sodium channel activity
a)
Primary Hyperaldosteronism
b)
Secondary Hyperaldosteronism
c)
Liddle’s Syndrome
65.
Screening test for hyperaldosteronism
a)
Plasma Aldosterone Concentration
b)
Renin Activity Ratio
c)
Saline Suppression Test
d)
Oral Sodium Loading Test
e)
Fludrocortisone Suppression test
66.
Confirmatory test for hyperaldosteronism
a)
Plasma Aldosterone Concentration
b)
Captopril Challenge Test
c)
Saline Suppression Test
d)
Oral Sodium Loading Test
e)
Fludrocortisone Suppression test
67.
Due to defective secretion of aldosterone and angiotensin Abnormal synthesis of renin may also be associated
a)
Hypoaldosteronism
b)
Pseudohypoaldosteronism
68.
Tests:
o Saline Suppression
o Furosemide Stimulation or Upright Posture
a)
Hypoaldosteronism
b)
Pseudohypoaldosteronism
69.
Characterized by the inability of the renal tubules to respond to the action of aldosterone
a)
Hypoaldosteronism
b)
Pseudohypoaldosteronism
70.
Fluid retention, low serum Na
a)
Increased ADH
b)
Decreased ADH
c)
Increased aldosterone
d)
Decreased aldosterone
e)
Increased renin
71.
Fluid loss, high serum Na+
a)
Increased ADH
b)
Decreased ADH
c)
Increased aldosterone
d)
Decreased aldosterone
e)
Increased renin
72.
Hypertension, high serum Na+, low serum K+
a)
Increased ADH
b)
Decreased ADH
c)
Increased aldosterone
d)
Decreased aldosterone
e)
Increased renin
73.
Low serum Na+, high serum K+
a)
Increased ADH
b)
Decreased ADH
c)
Increased aldosterone
d)
Decreased aldosterone
e)
Increased renin
74.
Hypertension
a)
Increased ADH
b)
Decreased ADH
c)
Increased aldosterone
d)
Decreased aldosterone
e)
Increased renin
75.
Principal androgen formed by adrenal cortex
a)
Dehydroepiandrosterone (DHEA)
b)
Aldosterone
c)
Norepinephrine
d)
Epinephrine
76.
Valuable in the assessment of adrenal cortical function
a)
Dehydroepiandrosterone (DHEA)
b)
Aldosterone
c)
Norepinephrine
d)
Epinephrine
77.
Highest concentration is found in the brain (CNS)
a)
Norepinephrine
b)
Epinephrine
78.
Acts as a neurotransmitter in both CNS and sympathetic nervous system
a)
Norepinephrine
b)
Epinephrine
79.
Major metabolites: 3-methoxy-4-hydroxyphenyl glycol (MHPG), Vanillylmandelic acid
a)
Norepinephrine
b)
Epinephrine
80.
Most abundant medullary hormone secreted in the adrenal medulla
a)
Norepinephrine
b)
Epinephrine
81.
Produced from norepinephrine and comes only from adrenal
a)
Norepinephrine
b)
Epinephrine
82.
Any form of stress that increases the cortisol levels stimulates its production
a)
Norepinephrine
b)
Epinephrine
83.
Adrenaline / Fight-or-flight Hormone
a)
Norepinephrine
b)
Epinephrine
84.
Colorimetry test: Pisano method for quantifying metanephrines and normetanephrines
a)
Norepinephrine
b)
Epinephrine
85.
Major metabolite of epinephrine
a)
Vanillylmandelic acid
b)
Metanephrines, Normetanephrines, Homovanillic acid
86.
Minor metabolite of epinephrine
a)
Vanillylmandelic acid
b)
Metanephrines, Normetanephrines, Homovanillic acid
87.
Major intact catecholamines present in urine
a)
Adrenaline
b)
Norephinephrine
c)
Dopamine
88.
What is the major metabolite of dopamine?
a)
Metanephrines
b)
Homovanillic acid
c)
Vanillylmandelic acid
d)
Normetanephrines
89.
Tumor of the adrenal medulla or sympathetic ganglia
a)
Pheochromacytoma
b)
Neuroblastoma
90.
Due to the overproduction of catecholamines
a)
Pheochromacytoma
b)
Neuroblastoma
91.
Screening test: Plasma metanephrine and normetanephrine
a)
Pheochromacytoma
b)
Neuroblastoma
92.
Confirmatory test: 24-hour urinary excretion of metanephrine and normetanephrine
a)
Pheochromacytoma
b)
Neuroblastoma
93.
Fatal malignant condition in children resulting to excessive production of norepinephrine
a)
Pheochromacytoma
b)
Neuroblastoma
94.
Screening test: High urinary excretion of HVA or VMA or both, and dopamine
a)
Pheochromacytoma
b)
Neuroblastoma
95.
Screening test for Neuroblastoma
a)
Plasma metanephrine and normetanephrine
b)
24-hour urinary excretion of metanephrine and normetanephrine
c)
High urinary excretion of HVA or VMA or both, and dopamine
96.
Screening test for Pheochromacytoma
a)
Plasma metanephrine and normetanephrine
b)
24-hour urinary excretion of metanephrine and normetanephrine
c)
High urinary excretion of HVA or VMA or both, and dopamine
97.
Confirmatory test for Pheochromacytoma
a)
Plasma metanephrine and normetanephrine
b)
24-hour urinary excretion of metanephrine and normetanephrine
c)
High urinary excretion of HVA or VMA or both, and dopamine
98.
Principal androgen synthesized in the testes (95%), <5% derived from adrenal precursors
a)
Testosterone
b)
Estrogen
c)
Progesterone
d)
Androgen
99.
Arises though structural alteration of the testosterone molecule
a)
Testosterone
b)
Estrogen
c)
Progesterone
d)
Androgen
100.
Functions: promotion of breast development, maturation of external genitalia, deposition of body fat, and termination of linear growth
a)
Testosterone
b)
Estrogen
c)
Progesterone
d)
Androgen
101.
Prime secretory product of the ovary
a)
Testosterone
b)
Estrogen
c)
Progesterone
d)
Androgen
102.
Dominant hormone responsible for the luteal phase cycle among female
a)
Testosterone
b)
Estrogen
c)
Progesterone
d)
Androgen
103.
Single best hormone to determine whether ovulation has occurred
a)
Testosterone
b)
Estrogen
c)
Progesterone
d)
Androgen
104.
Serves to prepare the uterus for pregnancy and the lobules of the breast for lactation
a)
Testosterone
b)
Estrogen
c)
Progesterone
d)
Androgen
105.
Fertility and ovulation marker
a)
Testosterone
b)
Estrogen
c)
Progesterone
d)
Androgen
106.
Testosterone peak
a)
Morning (8 AM)
b)
Night (8 PM)
107.
Testicular cancer
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
108.
Panhypopituitarism
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
109.
Decreased FSH, LH, and Testosterone
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
110.
Increased FSH, LH, and Testosterone
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
111.
Decreased FSH, LH, Increased Testosterone
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
112.
Increased FSH, LH, Decreased Testosterone
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
113.
Testes problem
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
114.
Anterior pituitary gland / hypothalamus problem
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
115.
Precocious puberty
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
116.
Klinefelter syndrome
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
117.
Most abundant estrogen in post-menopausal women
a)
Estrone
b)
Estradiol
c)
Estriol
d)
Estetrol
118.
Precursor of E1 and E3
a)
Estrone
b)
Estradiol
c)
Estriol
d)
Estetrol
119.
Used to assess ovarian function
a)
Estrone
b)
Estradiol
c)
Estriol
d)
Estetrol
120.
Estrogen found in maternal urine
a)
Estrone
b)
Estradiol
c)
Estriol
d)
Estetrol
121.
Major estrogen secreted by the placenta during pregnancy
a)
Estrone
b)
Estradiol
c)
Estriol
d)
Estetrol
122.
Natural steroid produced by human fetal liver
a)
Estrone
b)
Estradiol
c)
Estriol
d)
Estetrol
123.
Only produced during human pregnancy
a)
Estrone
b)
Estradiol
c)
Estriol
d)
Estetrol
124.
Colorimetry test: Kober reaction for measuring urinary estrogens
a)
True
b)
False
125.
Most abundant estrogen in pre-menopausal women
a)
Estrone
b)
Estradiol
c)
Estriol
d)
Estetrol
126.
Most potent estrogen secreted by the ovary (major estrogen)
a)
Estrone
b)
Estradiol
c)
Estriol
d)
Estetrol
127.
Sheehan’s syndrome
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
128.
Gonadotropin secreting tumors
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
129.
Ovarian tumors
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
130.
Decreased FSH, LH, Increased estradiol
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
131.
Increased FSH, LH, Decreased estradiol
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
132.
Increased FSH, LH, Increased Estradiol
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
133.
Decreased FSH, LH, Decreased Estradiol
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
134.
Menopause
a)
Primary hypergonadism
b)
Secondary hypergonadism
c)
Primary hypogonadism
d)
Secondary hypogonadism
100 %
