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ENDOCRINE SYSTEM

Total questions: 35

Worksheet time: 18mins

Name
Class
Date
1.

Which of the following is used in the treatment of hyperprolactinemia?

a)

Acetyl choline

b)

Dopamine

c)

Dopamine antagonist

d)

Neostigmine

2.

Which of the following is not a characteristic of Pendred syndrome?

a)

Defective organification of iodine

b)

Goiter

c)

Conduction deafness

d)

Sensorineural deafness

3.

Attention deficit hyperactive disorder in children is associated with which hormone resistance?

a)

Growth hormone

b)

Thyroid hormone

c)

Hypothalamic hormones

d)

Cortisol

4.

A 36-year old man came to the OPD for high BP, headache, palpitation. He also has shortness of breath sometimes and heavy sweating. On examination, he has tremors, looks agitated and pale. What is your provisional diagnosis?

a)

Panhypopituitarism

b)

Thyrotoxicosis

c)

Pheochromocytoma

d)

Cushing’s syndrome

5.

Normally the I/G ratio following a balanced diet is approximately (a)  

6.

Type-1 DM: Ketoacidic coma :: Type-2 DM: (a)  

7.

Deficiency of 21beta-hydroxylase accounts for 90% of the cases of (a)  

8.

Regarding the calorigenic effect of thyroid hormone, which of the following statements is true?

a)

One milligram of T3 will produce an excess of 1000 kcal.

b)

One microgram of T4 will produce an excess of 1000 kcal.

c)

One milligram of thyroxine will produce an excess of 1000 kcal.

d)

One milligram of tetraiodothyronine will produce an excess of 1000 cal.

9.

Read the following statements and choose the correct option. Statement A: Certain breast cancers, especially in perimenopausal women are estrogen-dependent. Statement B: Approximately 15–20% of cervical cancers have an amplification of the HER2/neu gene or overexpression of its protein product, leading to increased disease recurrence and worse prognosis. Note: HER2/neu = Human Epidermal growth factor Receptor 2.**

a)

Both are False.

b)

Only A is True.

c)

Only B is True.

d)

Both are True.

10.

A 22-year-old woman and her twin sister both complain of increasing diplopia. She has noted increasing fatigue and a 7-kg weight loss without dieting over the past 3 months. Physical examination shows exophthalmos and weak movement of extraocular muscles. In both, the thyroid gland is diffusely enlarged but painless and has no lymphadenopathy. A fine tremor is observed in her outstretched hands. A radionuclide scan of the thyroid shows a diffuse increase in uptake. The serum is most likely to show the following features on laboratory examination:

a)

Decreased free thyroxine level

b)

Increased triiodothyronine level

c)

Antibodies against TSH receptor

d)

Increased TRH level

11.

A 24-year-old G2, P1 woman is in the early second trimester. She complains of a small amount of vaginal bleeding for the past week and has had marked nausea and vomiting for 3 weeks. On examination, the uterus measures large for dates. An ultrasound examination shows intrauterine contents with a “snowstorm appearance”, without a fetus. The gross appearance of tissue obtained by dilation and curettage shows numerous grape-like vesicles. The substance that is most likely to be greatly increased in the serum of this patient is:

a)

Estradiol

b)

Alpha fetoprotein

c)

Human placental lactogen

d)

Human chorionic gonadotropin

12.

Open (a)   is an important indicator of congenital hypothyroidism.

13.

A 10-day-old male neonate presents with vomiting, poor feeding, weight loss, and dehydration. On examination, he has hypotension and hyperpigmentation. Lab reports show hyponatremia, hyperkalemia, and hypoglycemia. External genitalia appear normal.

Blood levels of which steroid precursor is to be checked and what is the probable diagnosis?


a)

17 hydroxypregnenolone congenital adrenal hyperplasia

b)

17 hydroxyprogesterone congenital adrenal hyperplasia

c)

Progesterone Pseudohypoaldosteronism

d)

dehydroepiandrosterone, Pseudohypoaldosteronism

14.

A 12-year-old boy is brought to the pediatric clinic for evaluation of progressive visual impairment. His parents report that he has difficulty seeing at night and has been bumping into objects. On examination, he is obese, has postaxial polydactyly, and mild intellectual disability. Fundoscopy reveals pigmentary retinopathy. Renal ultrasound shows hyperechogenic kidneys with poor corticomedullary differentiation. His younger sibling has similar features.**

a)

Sensorineural hearing loss

b)

Hypogonadism

c)

Café-au-lait spots

d)

Macrocephaly

15.

Which of the following national programmes has no relation to disorders or diseases of the endocrine system?**

a)
RBSK
b)

IDD

c)

NPPMTBI

d)

NPCDCS

16.

An 18 year old boy is brought to casualty with minor burns following a house fire. He tells that he did not even smell the smoke. There is H/O B/L orchidopexy at age 7. O/E no secondary sexual characters are developed, microphallus, Eunuchoid habitus. Which of the following best explains the underlying defect?

a)

Pituitary gonadotroph cell destruction

b)

Primary testicular failure due to seminiferous tubule dysgenesis

c)

Failure of migration of GnRH-secreting neurons from olfactory placode

d)

Mutation causing androgen receptor insensitivity

17.

Which of the following is not involved in characteristic triad of Wermer's Syndrome?

a)

Parathyroids

b)

Pancreatic islets

c)

Posterior Pituitary

d)

Anterior Pituitary

18.

Which of the following is not used to diagnose diabetic ketoacidosis?

a)

Serum glucose >250 mg/dl

b)

Serum potassium <3.5 mEq/l

c)

Serum by carbonate <15 mEq/l

d)

pH <7.3

19.

Which of the following will not be measured to diagnose metabolic syndrome?

a)

HDL levels

b)

Hip circumference

c)

Blood glucose

d)

Blood pressure

20.

Pioglitazone decreases blood glucose primarily by:

a)

Increasing insulin release from β-cells

b)

Decreasing hepatic gluconeogenesis

c)

Increasing GLUT-4 translocation via PPAR-γ activation

d)

Increasing incretin effect

21.

GLP-1 analogues produce weight loss mainly due to:

a)

Increased insulin release

b)

Delayed gastric emptying & satiety

c)

Increased renal glucose excretion

d)

Direct lipolysis

22.

Which drug causes downregulation of GnRH receptors when given continuously?

a)

Leuprolide

b)

Human chorionic gonadotropin

c)

Gonadorelin

d)

 Danazol

23.

A drug used to induce ovulation in infertility by blocking estrogen receptors:

a)

Letrozole

b)

Clomiphene

c)

Bromocriptine

d)

Leuprolide

24.

Select the false statement

a)

Mumps can cause suppurative bilateral parotitis.

b)

Mumps causes epididymo orchitis in postpubertal males.

c)

Mumps may present without parotitis is 10% cases.

d)

Mumps can also cause oophoritis and pancreatitis.

25.

Patient presents with a typhoid-like undulating fever along with epididymo-orchitis and prostatitis. He is a farmer and closely works with cows and goats. Name the most likely causative agent.**

a)

Brucella melitensis

b)

Brucella suis

c)

Rickettsia rickettsi

d)

Borrelia recurrentis

26.

Which of the following structures is most commonly found extending upward from the isthmus of the thyroid gland?

a)

Pyramidal lobe

b)

Zuckerkandl’s tubercle

c)

Inferior thyroid artery

d)

Levator glandulae thyroideae

27.

A 38-year-old man with acute pancreatitis develops transient hyperglycemia. Which anatomical region of the pancreas is most likely affected to cause early endocrine dysfunction?

a)

Head

b)

Neck

c)

Body

d)

Tail

28.

The anterior pituitary (adenohypophysis) develops from which embryological structure?

a)

Diencephalon

b)

Neural crest

c)

Rathke’s pouch

d)

Neuroectoderm

29.

Which of the following schedules of THE DRUGS AND COSMETIC RULES 1945 do hormone preparations come under?


a)

Schedule G

b)

Schedule H

c)

Schedule J

d)

Schedule L

30.

 All of the following statements about physiological changes during pregnancy are true, except:

a)

 Doubling time of maternal plasma hCG is 1.4-2 days in early pregnancy

b)

There is rise in BMR, and fall in maternal serum Iodine

c)

 Progesterone levels are abnormally high during ectopic pregnancy

d)

In pregnancy, there is hyperinsulinemia, particularly during third trimester


31.

 Read the following statements about hCG and pick the correct option:

  1. a) Stimulates Leydig cells of male foetus to produce testosterone

  2. b) Has immunosuppressive activity

  3. c) Inhibits both adrenal and placental steroidogenesis

  4. d) Promotes secretion of relaxin and progesterone from corpus luteum

  5. e) hCG levels in blood disappear within 2 days following pregnancy**

a)

a, b, c are correct, and d, e are false


b)

 b, d, e are correct, and c, d are false


c)

a, e, are correct, and b, c, d are false


d)

a, b, d are correct and c, e are false


32.

A baby weighing 5.3kg is born to a diabetic mother, with plumpy face, buried eyes and excessive buccal fat. Such a condition of the infant is called (a)  

33.

Based on the images given below identify the etiology of the condition

a)

hypothalamic hamartoma

b)

hydrocephalus

c)

tubercular meningitis

d)

head trauma

34.

Identify the condition from the given picture

a)

Hashimoto's thyroiditis

b)

graves disease

c)

multinodular goitre

d)

papillary carcinoma of thyroid


35.

Select the drugs that act as tocolytics (uterine relaxants)

a) ritodrine b)halothane c)nifedipine d) quinine

a)

a,b,c

b)

a,b,d

c)

only a

d)

all of the above