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BIOCHEMISTRY PART 1

Total questions: 90

Worksheet time: 46mins

Name
Class
Date
1.

The type of transport when Ca ion is translocated by a Ca-pump is known as:

a)

Symport

b)

Antiport

c)

Solubility dependent

d)

Uniport

e)

Concentration dependent

2.

When blood glucose enters the cell, it will be phosphorylated to from glucose 6-P. this means that a phosphate group binds to:

a)

Aldehyde on C number 1

b)

Aldehyde on C number 6

c)

Hydroxyl on C number 1

d)

Hydroxyl on C number 6

e)

Each C from 1 to 6

3.

During fasting, the body relies on energy obtained from the hydrolysis of:

a)

Glycogen

b)

Polypeptide

c)

Triacylglycerol

d)

Cellulose

e)

Amylum

4.

Glut 4 is a glucose transporter that transfers glucose into:

a)

Heart

b)

Liver

c)

Erythrocyte

d)

Muscle

e)

Brain

5.

Biotin works as a coenzyme in the process of:

a)

Methylation

b)

Carboxylation

c)

Hydroxylation

d)

Oxidation

e)

Decarboxylation

6.

A sprinter has finished running 100 m in less than 10 seconds. The process to obtain energy was:

a)

Aerobic with hydrolysis of high energy phosphates

b)

Anaerobic through the respiratory chain

c)

Aerobic with hydrolysis of creatine phosphate

d)

Aerobic through the respiratory chain

e)

Anaerobic with hydrolysis of high energy phosphates

7.

Which of the following isn’t a property of biomembrane?

a)

Constant

b)

Dynamic

c)

Fluid

d)

Bilayer

e)

asymmetric

8.

When optimum temperature of enzyme is 40 C, what do you expect of its condition at 0 C?

a)

Destroyed because of dehydration

b)

Conserved and can be reactivated

c)

Destroyed because enzyme is frozen

d)

Conserved but type of reaction has changed

e)

Destroyed because of denaturation

9.

Transportation of glucose by GLUT (Glucose transporter) is classified as:

a)

Active transport

b)

Ca-cotransport

c)

Facilitated diffusion

d)

Ca-antiport

e)

Simple diffusion

10.

Cholesterol molecules give some strength to biomembranes but also serve to:

a)

Limit water entering cell

b)

Transport glucose into cell

c)

Increase fluidity

d)

Decrease oxidative stress

e)

Transport Na into cell

11.

Fusion of vesicle with membrane is found as a way of transport mechanism in:

a)

Ca-pump

b)

Intestinal mucosa

c)

Nerve synapse

d)

Glut 1

e)

Na,K-pump

12.

Humans are heteroph and the source of energy is basically …

a)

Solar

b)

Water

c)

Plant

d)

Animal

e)

Seaweed

13.

Glucose absorption from intestinal mucosa is mostly coupled with the ion:

a)

Na+

b)

H+

c)

K+

d)

Mg2+

e)

Ca2+

14.

The strength of erythrocyte membrane to undergo cell deformability when passing through capillaries, depends very much on the role of:

a)

Membrane cholesterol

b)

Cytoskeleton

c)

Chloride transporter

d)

Glucose transporter

e)

Membrane protein

15.

Cells of the intestinal mucosa are interconnected by:

a)

Tight junction

b)

Spot desmosome

c)

Belt desmosome

d)

Gap junction

e)

Loose junction

16.

Energy obtained from food consumption is released in the body as:

a)

Heat

b)

ATP and water

c)

ATP, heat and water

d)

ATP

e)

ATP and heat

17.

When physical activity is gradually increasing, the body starts using energy obtained from the catabolism of …

a)

Amylum

b)

Cellulose

c)

Glycogen

d)

Polypeptide

e)

Triacylglycerol

18.

ATP is a general source of energy in the body. The monosaccharide residue in ATP molecule comes from:

a)

Deoxyribose

b)

Ribose

c)

Galactose

d)

Glucose

e)

Fructose

19.

A good model represent the lock and key theory is the activity of …

a)

Urease on urea

b)

Pepsin on protein

c)

Amylase on amylum

d)

Lipase on fat

e)

Dehydrogenase on alcohol

20.

Biomolecules of the plasma membrane that are located extracellularly and not found on other parts of the cellular membrane are made up of …

a)

Protein

b)

Carbohydrate

c)

Cholesterol

d)

Phospholipid

e)

Fatty acid

21.

The biomolecules in biomembranes that function for transport, signalling and other functional activities are made of:

a)

Phospholipid

b)

Cholesterol

c)

Triacylglycerol

d)

Protein

e)

Carbohydrate

22.

The kind of transport system when extrusion of 3 Na is accompanied by 2 K entering the cell can be found as a case of:

a)

Facilitated antiport

b)

Gradient driven transport

c)

Facilitated symport

d)

Active antiport

e)

Active symport

23.

ATP activates glucose by releasing one phosphate group to be attached on the glucose molecule. The enzyme doing this activity is glucokinase classified as:

a)

Transferase

b)

Oxidoreductase

c)

Isomerase

d)

Hydrolase

e)

Ligase

24.

Carbohydrate in membrane is one of the factors that causes asymmetry since carbohydrate:

a)

Prefers facing the intracellular fluid

b)

Is most present sticking out of the outer membrane layer

c)

Must be part of a liposaccharide

d)

Is connected with hydrophobic membrane center

e)

Is present as the smallest amount of biomolecules

25.

The smallest group of biomolecules in biomembrane consists of…

a)

Carbohydrate

b)

Glycolipid

c)

Phospholipid

d)

Cholesterol

e)

Protein

26.

The destructive action of free radicals can be inhibited by:

a)

Hydrolase

b)

Dehydrogenase

c)

Oxygenase

d)

Superoxide dismutase

e)

Catalase

27.

Brown fat plays an important role for babies because it:

a)

Contains high content of mitochondria to provide energy for growth

b)

Provides insulation for organs

c)

Provides lubrication for joints

d)

Contains high content of mitochondria capable of uncoupling process

e)

Provides fatty acids for synthesis of tissue fat

28.

Fat is chemically a triacylglycerol. This means that fat molecule contains 3 bonds of:

a)

Nucleotide

b)

Ether

c)

Ester

d)

Glyceride

e)

Peptide

29.

Fluidity and flexibility of biomembranes increase with increasing membrane content of:

a)

Unsaturated fatty acids

b)

Cholesterol

c)

Glycolipid

d)

Triacylglycerol

e)

Saturated fatty acids

30.

The density of biomembrane is determined by its content of:

a)

Phospholipid

b)

Protein

c)

Carbohydrate

d)

Glycolipid

e)

Cholesterol

31.

In case of competitive enzyme inhibition, the competing compounds to occupy the active site are:

a)

Coenzyme and product

b)

Coenzyme and inhibitor

c)

Substrate and inhibitor

d)

Product and inhibitor

e)

Substrate and coenzyme

32.

Biochemical reactions in the body proceed lifelong at a normal temperature of 36.5 C isothermically. The system that makes this possible is primarily:

a)

Enzyme

b)

Body water

c)

Energy

33.

Glucose easily dissolves in water because it contains many groups of:

a)

Carbonyl

b)

Aldehyde

c)

Sulfhydryl

d)

Carboxyl

e)

Hydroxyl

34.

CO is fatally toxic since it can inhibit:

a)

Cytochrome oxidase

b)

ATP synthase

c)

NAD dehydrogenase

d)

Succinate dehydrogenase

e)

ATP transferase

35.

Ether used in anesthesia is a diethylether, meaning that the molecule is made up of 2 ethyl groups connected by:

a)

–O–

b)

–NH–

c)

–S–

d)

–S–S–

e)

–C–

36.

Coupling reactions always lose some energy that cannot be utilized. Fate of this energy is:

a)

Absorbed by tissues

b)

Converted to ATP

c)

Converted to heat

d)

Conserved by the body

e)

Converted to water

37.

A double bonded oxygen at the end of a carbon chain is found in the molecular structure of a:

a)

Ether

b)

Acid

c)

Aldehyde

d)

Ester

e)

Ketone

38.

The lipid mostly found in myelin sheath of nerves is:

a)

Phospholipid

b)

Cholesterol

c)

Sphingolipid

d)

Fatty acid

e)

Triacylglycerol

39.

Conjugation of 2 molecules means uniting two groups of the molecules to form a bigger one with the release of:

a)

CO2

b)

H2S

c)

H2

d)

H2O

e)

NH3

40.

A special and unique characteristic feature that is found in enzymes but not found in inorganic catalysts is:

a)

Resistant to high temperature

b)

Only active for a specific reaction

c)

Soluble in lipid solution

d)

Only active at low pH

e)

Low molecular weight

41.

Detoxification through hydroxylation is carried out by:

a)

Oxidase

b)

Catalase

c)

Oxygenase

d)

Superoxide dismutase

e)

Hydrolase

42.

Simple diffusion is a membrane transport mechanism that:

a)

Is driven by ATP as source of energy

b)

Moves particles from high to low concentration

c)

Applies only to absorption by the intestinal wall

d)

Does not apply to gas particles

e)

Is good to translocate large molecules

43.

O2 can diffuse through the membrane of alveoli and the endothelium of capillary blood vessel because of:

a)

The high affinity of O2 to oxygen carrier within erythrocyte

b)

The difference of partial pressure of O2 within alveoli and blood

c)

The molecular weight of O2 molecule which is very small

d)

The solubility of O2 in the blood

e)

The affinity of O2 with the protein in the blood

44.

Which of the following enzymes related to digestion is secreted by salivary gland?

a)

Trypsin

b)

Enterokinase

c)

Lactase

d)

Pepsin

e)

Amylase

45.

The purpose of metabolism of xenobiotics is:

a)

To increase their fat solubility

b)

To decrease their pH

c)

To increase their surface tension

d)

To decrease their affinity to protein

e)

To increase their water solubility

46.

The main lipid component of the lung surfactant is:

a)

Cholesterol

b)

Dipalmitoyl lecithin

c)

Triacylglycerol

d)

Arachidonic acid

e)

Sphingomelyn

47.

Hepatic disease leads to major elevation of the blood level of which one of the following substances?

a)

Heme

b)

Bile acid

c)

Conjugated bilirubin

d)

Biliverdin

e)

Unconjugated bilirubin

48.

Which one of the following organs is most involved in the metabolism of xenobiotics?

a)

Lung

b)

Kidney

c)

Lymphoid glands

d)

Liver

e)

Spleen

49.

Which one of the following organs secretes cholesterol esterase?

a)

Stomach

b)

Pancreas

c)

Spleen

d)

Liver

e)

Gall bladder

50.

Insulin hormone contains two polypeptide chains that are linked together through which kind of bonding?

a)

Disulfide

b)

Glycoside

c)

Hydrogen

d)

Peptide

e)

Ester

51.

The chloride shift is the exchange of chloride ion with

a)

CO2

b)

O2

c)

Bicarbonate ion

d)

Na ion

e)

K ion

52.

Which one of the following organs synthesizes enterokinase?

a)

Intestine

b)

Gall bladder

c)

Liver

d)

Kidney

e)

Pancreas

53.

Hypoventilation is physiological mechanism to:

a)

Lower [CO2] in the blood and increase blood pH

b)

Raise [CO2] in the blood and decrease blood pH

c)

Lower [CO2] in the blood and decrease blood pH

d)

Raise [CO2] in the blood and increase blood pH

e)

Lower [CO2] in the blood and increase blood pH

54.

Most of water from the consumed food is absorbed in the:

a)

Duodenum

b)

Ileum

c)

Gaster

d)

Colon

e)

Jejunum

55.

A 38 year old women is found to have an obstructing gallstone in the common bile duct. What is the impact of this condition?

a)

Increased recycling of bile salts

b)

Increased absorption of cholesterol from the intestine

c)

Decreased excretion of protein in the feces

d)

Increased digestion of carbohydrate in the intestine

e)

Increased excretion of fat in the feces

56.

Vitamin B6 deficiency would be expected to result in the inhibition of:

a)

Porphobilinogen deaminase

b)

ALA synthase

c)

Uroporphyrinogen decarboxylase

d)

ALA dehydrates

e)

Ferrochelatase

57.

The major mechanism of reaction in phase 1 of metabolism of xenobiotics is:

a)

Conjugation

b)

Hydroxylation

c)

Carboxylation

d)

Oxidation

e)

Deamination

58.

Ammonia in colon is the product of putrefaction and fermentation by microorganism from:

a)

Protein

b)

Strach

c)

Triacylglycerol

d)

Cholesterol

e)

Fatty acid

59.

Which statement is true concerning the intestinal brush border membrane?

a)

Alpha amylase is secreted by brush border membrane

b)

Enterokinase is required for the absorption of glucose

c)

Sucrase is only found in the brush border membrane

d)

Maltose crosses the brush border membrane

e)

Bile salt is required for the absorption of glucose

60.

The normal pH of the blood occurs if the ratio [BHCO3] and [H2CO3] is:

a)

15

b)

20

c)

5

d)

10

e)

25

61.

One of the characteristics of porphyrin is:

a)

It is a hemoprotein

b)

Is is an amphoter

c)

It contains Zn

d)

It is a colorless substance

e)

It is a component of vitamin B1

62.

Which of the following organs is the site of procarboxypeptidase synthesis?

a)

Liver

b)

Stomach

c)

Pancreas

d)

Gallbladder

e)

Spleen

63.

In what state are saturated fatty acids found at room temperature?

a)

Gas

b)

Vapour

c)

Liquid

d)

Solids

e)

Condensed

64.

Biosynthesis of heme requires which on of the following substances?

a)

Glutamic acid

b)

Propionyl CoA

c)

Succinyl CoA

d)

Ferric ion

e)

Acetyl CoA

65.

Mostly digestive products are processed through a metabolic pathway into a common product, namely:

a)

Pyruvic acid

b)

Glucose 6-phosphate

c)

ATP

d)

Acetyl-CoA

e)

Fructose 6-phosphate

66.

Which of the following enzymes has autocatalytic characteristic?

a)

Pepsin

b)

Lipase

c)

Amylase

d)

Cholesterol esterase

e)

Enterokinase

67.

UDP glucuronyltransferase participates in the conjugation process of bilirubin in order to make it:

a)

Water soluble and directly enter the blood system

b)

Less soluble in water for easy storage in gall bladder

c)

Less soluble in water to protect from oxidation

d)

Water soluble and secreted into the bile

e)

Water soluble and directly secreted into the intestinum

68.

Which of the following substances is the substrate of lipase?

a)

Arachidonate

b)

Palmitate

c)

Prostaglandin

d)

Cholesterol

e)

Triacylglycerol

69.

Complex lipids with fatty acid components that bind to sugar are called:

a)

Glycolipid

b)

Glycerophospholipid

c)

Sphingolipid

d)

Glucosan

e)

Amylopectin

70.

Why is hydrochloric acid secretion within the stomach important in digestion?

a)

It is required for the activity of alpha-amylase

b)

It drives secondary active transport of amino acid

c)

It converts pepsinogen to pepsin

d)

It is required for lipid digestion

e)

It stimulates the cleavage of trypsinogen to trypsin

71.

Which of the following substances related to digestion is secreted by liver?

a)

Biliverdin

b)

Bilirubin

c)

Bicarbonate

d)

Lipase

e)

Bile acid

72.

Which of the following cases of acid-base imbalance is present in patients with renal failure?

a)

Metabolic acidosis

b)

Respiratory alkalosis

c)

Metabolic alkalosis

d)

Respiratory acidosis

e)

Metabolic alkalosis hypokalemia

73.

Which one of the following enzymes contains iron porphyrin?

a)

Carbonic anhydrase

b)

Ferrochelatase

c)

Peroxidase

d)

Carboxypeptidase

e)

Glutaminase

74.

Metabolic acidosis occurs in:

a)

Bronchitis

b)

Pneumonia

c)

Asthma bronchiale

d)

Cushing syndrome

e)

Severe diarrhea

75.

Which of the following acid-base imbalance is present in patients with uncontrolled diabetes mellitus?

a)

Respiratoric alkalosis

b)

Metabolic alkalosis with hypokalemia

c)

Metabolic acidosis

d)

Respiratoric acidosis

e)

Metabolic alkalosis

76.

Edema can occur in hypoalbuminemia which is a complication of:

a)

Lung disease

b)

Severe diarrhea

c)

Liver disease

d)

Heart disease

e)

Severe vomiting

77.

The mechanism of reaction in phase 2 of metabolism of xenobiotics is:

a)

Hydrolysis

b)

Conjugation

c)

Dehydrogenation

d)

Decarboxylation

e)

Reduction

78.

Aldose is referred to as a reducing sugar. This means that aldehydes are capable to be oxidized forming:

a)

R-CHO

b)

R-COOH

c)

R-CO

d)

R-O-R

e)

R-OH

79.

The regulatory enzyme of the biosynthesis of porphyrin is:

a)

Protoporphyrinogen oxidase

b)

Uroporphyrinogen decarboxylase

c)

ALA synthase

d)

Porphobilinogen deaminase

e)

ALA dehydratase

80.

During a breathing cycle:

a)

Gas exchange between the alveoli and the capillary blood can occur at all times

b)

Atmospheric water vapour is taken up by the lung

c)

There is net uptake of nitrogen by the blood

d)

The alveolar gases are completely exchanged for atmospheric gases

e)

Gas exchange with the capillary blood occurs at the surface of all the airways

81.

The normal color of feces is due to which one of the following substances?

a)

Stercobilin

b)

Biliverdin

c)

Bilirubin

d)

Cholesterol

e)

Bile acid

82.

What is the normal range of the blood’s pH?

a)

7.50 – 7.43

b)

7.23 – 7.45

c)

7.25 – 7.50

d)

7.48 – 7.25

e)

7.35 – 7.45

83.

The main buffer system in erythrocyte is:

a)

H2CO3 – BHCO3 buffer system

b)

Lactate buffer system

c)

Phosphate buffer system

d)

Albumin buffer system

e)

Hemoglobin buffer system

84.

The process of chloride shift occurs in:

a)

The wall of alveoli

b)

The membrane of erythrocyte

c)

The membrane of leucocyte

d)

The membrane of enterocyte

e)

The membrane of blood vessel

85.

The concentration of protein human in human. Plasma is important in determining the distribution fluid between blood and tissue. The major protein in human plasma is:

a)

Laminin

b)

Albumin

c)

Alpha globulin

d)

Gamma globulin

e)

Beta globulin

86.

Which of the following organs are important in regulating the pH of the blood?

a)

Liver and spleen

b)

Kidney and lung

c)

Kidney and liver

d)

Lung and liver

e)

Liver and muscles

87.

Proteins are linear heteropolymers of α-amino acids. Alpha carbonof amino acids is carbon number?

a)

2

b)

3

c)

5

d)

4

e)

1

88.

Hepatic disease leads to major elevation of the blood level of

a)

Bile acid

b)

Biliverdin

c)

Cholesterol

d)

Conjugated bilirubin

e)

Unconjugated bilirubin

89.

Which one of the following substances is strong acid?

a)

Lactic acid

b)

Hydrochloric acid

c)

Carbonic acid

d)

Acetic acid

e)

Phosphoric acid

90.

Which of the following organs has no role in digestion

a)

Stomach

b)

Pancreas

c)

Liver

d)

Mouth

e)

Spleen