Free Printable X-Linked Traits and Pedigree Analysis

Worksheets

X-Linked Traits and Pedigree Analysis

Total questions: 24

Worksheet time: 12mins

Name

Class

Date

Fill in the Blank (converted to MCQ). Use the word bank to choose the best answer: carrier; X-linked recessive; pedigree; sex chromosomes.

X-linked recessive

Pedigree

True or False (converted to MCQ). Statement: Fathers pass their X chromosome to all sons.

True

False

Multiple Choice. A pedigree shows many affected males and no father-to-son transmission. Which pattern fits best?

Autosomal dominant

X-linked recessive

Short Answer (converted to MCQ). Why can fathers not pass X-linked recessive traits to sons?

Fathers pass Y chromosomes to sons and X chromosomes to daughters.

Fathers pass X chromosomes to sons and Y chromosomes to daughters.

Matching. Terms: A. X-linked recessive; B. Carrier; C. Pedigree; D. Hemizygous; E. Hemophilia; F. Color blindness; G. X-linked dominant; H. Y-linked. Match each description to the correct term: Describes males with one copy of X-linked genes (XY) for which no second allele exists; Individual with one recessive allele who can pass it on but typically shows no symptoms; Trait passed from father to all sons only; never through daughters; Family chart used to trace inheritance across generations.

Describes males with one copy of X-linked genes (XY) for which no second allele exists

Hemizygous

Individual with one recessive allele who can pass it on but typically shows no symptoms

Carrier

Trait passed from father to all sons only; never through daughters

Y-linked

Family chart used to trace inheritance across generations

Pedigree

Matching. Terms: A. X-linked recessive; B. Carrier; C. Pedigree; D. Hemizygous; E. Hemophilia; F. Color blindness; G. X-linked dominant; H. Y-linked. Match each description to the correct term: Classic X-linked bleeding disorder used in genetics examples; Common X-linked vision condition affecting red–green perception; Pattern where one copy on the X produces the trait in both sexes; Pattern where males are more often affected and female carriers transmit to sons.

Classic X-linked bleeding disorder used in genetics examples

Hemophilia

Common X-linked vision condition affecting red–green perception

Color blindness

Pattern where one copy on the X produces the trait in both sexes

X-linked dominant

Pattern where males are more often affected and female carriers transmit to sons

X-linked recessive

Fill in the Blank (Word Bank: carrier, X-linked recessive, pedigree, sex chromosomes, color blindness, hemophilia). Traits more often affect males because they have a single X.

Mitochondria

Autosomal recessive

X-linked recessivel

Y-linked

Fill in the Blank (Word Bank: carrier, X-linked recessive, pedigree, sex chromosomes, color blindness, hemophilia). In an X-linked recessive pattern, a female with one mutant allele is a ______ who can pass it to sons.

Affected female

Hemizygote

Proband

Carrier

Fill in the Blank (Word Bank: carrier, X-linked recessive, pedigree, sex chromosomes, color blindness, hemophilia). A family-history chart used to trace traits is a ______.

Punnett square

Pedigree

Karyotype

Linkage map

10.

Fill in the Blank (Word Bank: carrier, X-linked recessive, pedigree, sex chromosomes, color blindness, hemophilia). A classic human X-linked bleeding disorder is ______, which involves clotting factor genes.

Albinism

Sickle-cell disease

Cystic fibrosis

Hemophilia

11.

Fill in the Blank (Word Bank: carrier, X-linked recessive, pedigree, sex chromosomes, color blindness, hemophilia). Biological sex in humans is determined by the ______, typically XX for females and XY for males.

Sex chromosomes

Autosomes

Mitochondrial genomes

Barr bodies

12.

Fill in the Blank (Word Bank: carrier, X-linked recessive, pedigree, sex chromosomes, color blindness, hemophilia). Deficiency in red–green perception is called ______, and it is more common in males.

Night blindness

Hemophilia

Color blindness

Macular degeneration

13.

True or False. Fathers pass their X chromosome to all sons.

True

False

14.

True or False. A daughter of an affected father and a carrier mother can be affected by an X-linked recessive trait.

True

False

15.

True or False. X-linked recessive traits often skip generations via carrier females.

True

False

16.

True or False. Carrier females are unaffected because the allele is on the Y chromosome.

True

False

17.

True or False. In X-linked recessive pedigrees, more males than females are affected.

True

False

18.

Multiple Choice. A pedigree shows many affected males and no father-to-son transmission. Which pattern fits best?

Autosomal dominant

X-linked recessive

Autosomal recessive

Mitochondrial

19.

Multiple Choice. Which genotype represents a female carrier for an X-linked recessive trait?

$X^N$ $X^c$

$X^N$ $X^N$

X Y

$X^c X^c$

20.

Multiple Choice. A carrier mother and unaffected father have sons. What percent are expected to be affected?

25%

50%

100%

21.

Select all statements that correctly distinguish X-linked recessive from autosomal recessive. (Hint: 2 possible answers)

More affected males than females are observed

No father-to-son transmission is seen

Affected fathers with carrier mothers produce only affected daughters

Both sexes are affected equally in sibships

22.

Fathers cannot pass X-linked recessive traits to sons, but daughters may inherit them. Choose the best explanation.

Fathers give Y to sons and X to daughters; with a carrier mother, daughters may inherit the mutant X and be carriers or affected

Fathers give X to sons and Y to daughters; daughters never inherit X-linked traits

Sons receive X from father and Y from mother; daughters receive only X from mother

X-linked traits are on autosomes, so inheritance is equal in both sexes

23.

For a carrier mother ( $X^N X^c$ ) and normal father ( $X^N Y$ ), state expected genotype/phenotype ratios for sons and daughters.

Sons: 100% $X^N$ $Y;$ Daughters: 100% $X^N$ $X^N$

Sons: 50% $X^N$ $Y$ unaffected, 50% $X^c$ $Y$ affected; Daughters: 50% $X^N$ $X^N$ unaffected, 50% $X^N$ $X^c$ carriers

Sons: 50% X^N Y affected, 50% X^c Y unaffected; Daughters: 50% $X^N X^c$ affected, 50% $X^c X^c$ carriers

Sons: 25% affected, 75% unaffected; Daughters: 25% carriers, 75% unaffected

24.

Pedigrees and Punnett models predict risks for sex-linked conditions; justify with evidence and reasoning. Choose the best-supported claim.

They predict risks by matching inheritance to meiosis patterns, including more affected males and absence of father-to-son transmission; a carrier-mother × normal-father cross predicts 50% affected sons and 50% carrier daughters

They cannot predict risks because family histories vary and Punnett squares ignore sex chromosomes

They always predict equal numbers of affected males and females for X-linked traits

They show father-to-son transmission is common in X-linked recessive traits

100 %

X-Linked Traits and Pedigree Analysis

Total questions: 24

Worksheet time: 12mins

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