WorksheetsQuiz on Approach to Thrombocytopenia
Total questions: 14
Worksheet time: 12mins
Which platelet count defines thrombocytopenia?
<140,000/ul or 140 x10⁹/L
140-400 x10⁹/L
100-139 x10⁹/L
<50 x10⁹/L
A patient has a platelet count of 110 x10⁹/L. How would you classify their thrombocytopenia?
Mild
Moderate
Severe
Very severe
What is the main cause of isolated thrombocytopenia?
Increased platelet destruction
Decreased platelet production
Increased red blood cell production
Decreased white blood cell destruction
Thrombocytopenia accompanied by anemia and leukopenia suggests a primary bone marrow disorder rather than isolated platelet destruction because:
Because thrombocytopenia always occurs alone
Because anemia and leukopenia are unrelated to bone marrow function
Because only platelets are destroyed in isolated thrombocytopenia
Because multiple cell lines are affected, indicating a problem with production in the bone marrow
Which metabolic disease is associated with acquired thrombocytopenia?
Gaucher’s disease
Fanconi anemia
Dengue
Wiskott-Aldrich syndrome
Bone marrow infiltration can lead to thrombocytopenia by which of the following mechanisms?
Bone marrow infiltration by diseases such as leukaemia can crowd out normal platelet-producing cells, leading to thrombocytopenia.
Bone marrow infiltration increases platelet production, causing thrombocytopenia.
Bone marrow infiltration has no effect on platelet count.
Bone marrow infiltration only affects red blood cells, not platelets.
Which of the following is an example of autoimmune-mediated platelet destruction leading to thrombocytopenia?
Heparin-induced thrombocytopenia
ITP (Idiopathic Thrombocytopenic Purpura)
Splenomegaly
Vitamin B12 deficiency
Which two types of diseases are being compared in the provided material?
Platelet disorders and immune disorders
Coagulation factors and metabolic disorders
Platelet disorders and coagulation factors
Platelet disorders and neurological disorders
Which symptom is most commonly associated with platelet disorders?
Hemarthrosis (joint bleeding)
Large bruises (hematomas)
Petechiae (small red/purple dots)
Internal bleeding (e.g., gastrointestinal)
Where does bleeding typically occur in coagulation disorders?
Skin, mucous membranes (e.g., nose, gums)
Joints, muscles, internal organs
Only in the gums
Only in the skin
Which of the following is considered a significant episode of epistaxis according to clinical criteria?
Nosebleed with an identifiable cause, occurring once a year
Nosebleed lasting less than 10 minutes, with no other symptoms
More than 5 episodes per year, requiring hospitalisation and treatment, with no identifiable cause
Nosebleed after trauma, lasting less than 5 minutes
What is the clinical significance of gum bleeding in the oral cavity?
Bleeding after eating spicy food
Gum bleeding with frank blood in sputum or bleeding after bites to lips, cheek, and tongue for more than 10 minutes on more than one occasion
Bleeding only after brushing teeth
Bleeding that stops within 2 minutes
Briefly discuss on laboratory investigation of thrombocytopenia (10 marks).
Briefly discuss on immune thrombocytopenia in children (10 marks)
